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Literature DB >> 3339713

Characterization of vaccinia virus growth factor biosynthetic pathway with an antipeptide antiserum.

W Chang¹, J G Lim, I Hellström, L E Gentry.

Abstract

A synthetic peptide derived from vaccinia virus growth factor (VGF) was used as an immunogen to prepare antiserum able to immunoprecipitate native VGF from both vaccinia virus-infected cell lysate and cell-free medium. Pulse-chase, tunicamycin treatment, and carbohydrate trimming experiments revealed that VGF is synthesized as a 19-kilodalton (kDa) precursor which is rapidly modified to a high-mannose-type 22-kDa protein. This cell-associated form is further processed into a 25-kDa polypeptide which, after proteolytic cleavage, releases the mature VGF into the medium as a 22-kDa glycoprotein.

Entities: Chemical Disease Gene Species

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Year: 1988 PMID： 3339713 PMCID： PMC253672

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

11 in total

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3. Mapping and sequencing of a gene from myxoma virus that is related to those encoding epidermal growth factor and transforming growth factor alpha.

Authors: C Upton; J L Macen; G McFadden
Journal: J Virol Date: 1987-04 Impact factor: 5.103

4. Epidermal growth factor receptor occupancy inhibits vaccinia virus infection.

Authors: D A Eppstein; Y V Marsh; A B Schreiber; S R Newman; G J Todaro; J J Nestor
Journal: Nature Date: 1985 Dec 19-1986 Jan 1 Impact factor: 49.962

5. Characterization of site-specific antibodies to the erbB gene product and EGF receptor: inhibition of tyrosine kinase activity.

Authors: L E Gentry; A Lawton
Journal: Virology Date: 1986-07-30 Impact factor: 3.616

6. Inverted terminal repetition in vaccinia virus DNA encodes early mRNAs.

Authors: R Wittek; E Barbosa; J A Cooper; C F Garon; H Chan; B Moss
Journal: Nature Date: 1980-05-01 Impact factor: 49.962

7. Similarity between the vaccinia virus 19K early protein and epidermal growth factor.

Authors: A H Reisner
Journal: Nature Date: 1985 Feb 28-Mar 6 Impact factor: 49.962

8. Vaccinia virus encodes a polypeptide homologous to epidermal growth factor and transforming growth factor.

Authors: J P Brown; D R Twardzik; H Marquardt; G J Todaro
Journal: Nature Date: 1985 Feb 7-13 Impact factor: 49.962

9. Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors.

Authors: M C Blomquist; L T Hunt; W C Barker
Journal: Proc Natl Acad Sci U S A Date: 1984-12 Impact factor: 11.205

10. Vaccinia virus growth factor stimulates tyrosine protein kinase activity of A431 cell epidermal growth factor receptors.

Authors: C S King; J A Cooper; B Moss; D R Twardzik
Journal: Mol Cell Biol Date: 1986-01 Impact factor: 4.272

7 in total

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Authors: D D Spyropoulos; V Stallard; B E Roberts; L K Cohen
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2. The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus form a complex and function together to down-regulate the epidermal growth factor receptor.

Authors: A E Tollefson; A R Stewart; S P Yei; S K Saha; W S Wold
Journal: J Virol Date: 1991-06 Impact factor: 5.103

6. Viral growth factor- and STAT3 signaling-dependent elevation of the TCA cycle intermediate levels during vaccinia virus infection.

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7. Alteration in Cellular Signaling and Metabolic Reprogramming during Viral Infection.

Authors: Anil Pant; Lara Dsouza; Zhilong Yang
Journal: mBio Date: 2021-09-14 Impact factor: 7.867