Literature DB >> 7527087

Isolation of a monoclonal antibody which blocks vaccinia virus infection.

W Chang1, J C Hsiao, C S Chung, C H Bair.   

Abstract

We have isolated a monoclonal antibody, B2, that neutralizes vaccinia virus infection. B2 reacts with a trypsin-sensitive cell surface epitope. B2 does not neutralize infection of herpes simplex virus, suggesting that the B2-reactive epitope is specifically involved in vaccinia virus entry. A survey of 12 different cell lines reveals a correlation between B2 reactivity and susceptibility to vaccinia virus infection. In addition, B2 interferes with vaccinia virus adsorption to target cells. Taken together, the B2-reactive epitope is part of a receptor that appears important for vaccinia virus entry.

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Year:  1995        PMID： 7527087      PMCID： PMC188602     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  36 in total

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Review 6.  Virus receptors: binding, adhesion strengthening, and changes in viral structure.

Authors:  A M Haywood
Journal:  J Virol       Date:  1994-01       Impact factor: 5.103

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Authors:  E J Wolffe; S N Isaacs; B Moss
Journal:  J Virol       Date:  1993-08       Impact factor: 5.103

8.  Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV.

Authors:  B Delmas; J Gelfi; R L'Haridon; L K Vogel; H Sjöström; O Norén; H Laude
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Authors:  D Naniche; T F Wild; C Rabourdin-Combe; D Gerlier
Journal:  J Gen Virol       Date:  1992-10       Impact factor: 3.891

10.  Characterization of a vaccinia virus-encoded 42-kilodalton class I membrane glycoprotein component of the extracellular virus envelope.

Authors:  S N Isaacs; E J Wolffe; L G Payne; B Moss
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103
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  8 in total

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5.  Isolation and characterization of a Chinese hamster ovary mutant cell line with altered sensitivity to vaccinia virus killing.

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Journal:  J Virol       Date:  1996-07       Impact factor: 5.103

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7.  A27L protein mediates vaccinia virus interaction with cell surface heparan sulfate.

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8.  Vaccinia virus interactions with the cell membrane studied by new chromatic vesicle and cell sensor assays.

Authors:  Z Orynbayeva; S Kolusheva; N Groysman; N Gavrielov; L Lobel; R Jelinek
Journal:  J Virol       Date:  2006-11-15       Impact factor: 5.103
  8 in total

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