Melanie T Odenkirk1, Kelly G Stratton2, Lisa M Bramer2, Bobbie-Jo M Webb-Robertson3,4, Kent J Bloodsworth3, Matthew E Monroe3, Kristin E Burnum-Johnson5, Erin S Baker1,6. 1. Department of Chemistry, North Carolina State University, Raleigh, NC 27606, USA. 2. National Security Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA. 3. Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA. 4. Department of Biostatistics and Informatics, University of Colorado, Aurora, CO 80045, USA. 5. Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA. 6. Comparative Medicine Institute, North Carolina State University, Raleigh, NC 27695, USA.
Abstract
While a molecular assessment of the perturbations and injury arising from diseases is essential in their diagnosis and treatment, understanding changes due to preventative strategies is also imperative. Currently, complex diseases such as cardiovascular disease (CVD), the leading cause of death worldwide, suffer from a limited understanding of how the molecular mechanisms taking place following preventive measures (e.g., exercise) differ from changes occurring due to the injuries caused from the disease (e.g., myocardial infarction (MI)). Therefore, this manuscript assesses lipidomic changes before and one hour after exercise treadmill testing (ETT) and before and one hour after a planned myocardial infarction (PMI) in two separate patient cohorts. Strikingly, unique lipidomic perturbations were observed for these events, as could be expected from their vastly different stresses on the body. The lipidomic results were then combined with previously published metabolomic characterizations of the same patients. This integration provides complementary insights into the exercise and PMI events, thereby giving a more holistic understanding of the molecular changes associated with each.
While a molecular assessment of the n class="Chemical">perturbationpan>s and inpan>jury arisinpan>g from diseases is essenpan>tial inpan> their diagnpan>osis and treatmenpan>t, understandinpan>g changes due to prevenpan>tative strategies is also imperative. Currently, complex diseases such as cardiovascular disease (CVD), the leading cause of death worldwide, suffer from a limited understanding of how the molecular mechanisms taking place following preventive measures (e.g., exercise) differ from changes occurring due to the injuries caused from the disease (e.g., myocardial infarction (MI)). Therefore, this manuscript assesses lipidomic changes before and one hour after exercise treadmill testing (ETT) and before and one hour after a planned myocardial infarction (PMI) in two separate patient cohorts. Strikingly, unique lipidomic perturbations were observed for these events, as could be expected from their vastly different stresses on the body. The lipidomic results were then combined with previously published metabolomic characterizations of the same patients. This integration provides complementary insights into the exercise and PMI events, thereby giving a more holistic understanding of the molecular changes associated with each.
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