Literature DB >> 33396426

Role of Human Mesenchymal Stem Cells in Regenerative Therapy.

Jayavardini Vasanthan1,2, Narasimman Gurusamy1, Sheeja Rajasingh1, Vinoth Sigamani1, Shivaani Kirankumar1,2, Edwin L Thomas1,3, Johnson Rajasingh1,3,4.   

Abstract

Mesenchymal stem cells (MSCs) are multipotent cells which can proliferate and replace dead cells in the body. MSCs also secrete immunomodulatory molecules, creating a regenerative microenvironment that has an excellent potential for tissue regeneration. MSCs can be easily isolated and grown in vitro for various applications. For the past two decades, MSCs have been used in research, and many assays and tests have been developed proving that MSCs are an excellent cell source for therapy. This review focusses on quality control parameters required for applications of MSCs including colony formation, surface markers, differentiation potentials, and telomere length. Further, the specific mechanisms of action of MSCs under various conditions such as trans-differentiation, cell fusion, mitochondrial transfer, and secretion of extracellular vesicles are discussed. This review aims to underline the applications and benefits of MSCs in regenerative medicine and tissue engineering.

Entities:  

Keywords:  differentiation; mesenchymal stem cells; regenerative therapy; tissue engineering

Mesh：

Year:  2020        PMID： 33396426      PMCID： PMC7823630          DOI： 10.3390/cells10010054

Source DB:  PubMed          Journal:  Cells        ISSN： 2073-4409            Impact factor:   6.600


  106 in total

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Authors:  L R Kaiser
Journal:  Top Health Care Financ       Date:  1992

Review 2.  Adult Stem Cells for Regenerative Therapy.

Authors:  Narasimman Gurusamy; Abdulrhman Alsayari; Sheeja Rajasingh; Johnson Rajasingh
Journal:  Prog Mol Biol Transl Sci       Date:  2018-09-06       Impact factor: 3.622

Review 3.  Reprogramming of somatic cells.

Authors:  Johnson Rajasingh
Journal:  Prog Mol Biol Transl Sci       Date:  2012       Impact factor: 3.622

Review 4.  Application areas of 3D bioprinting.

Authors:  Ibrahim T Ozbolat; Weijie Peng; Veli Ozbolat
Journal:  Drug Discov Today       Date:  2016-04-13       Impact factor: 7.851

5.  Bioactive nanoparticles stimulate bone tissue formation in bioprinted three-dimensional scaffold and human mesenchymal stem cells.

Authors:  Guifang Gao; Arndt F Schilling; Tomo Yonezawa; Jiang Wang; Guohao Dai; Xiaofeng Cui
Journal:  Biotechnol J       Date:  2014-09-10       Impact factor: 4.677

6.  A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells.

Authors:  W-J Wan-Ju Li; Richard Tuli; Chukwuka Okafor; Assia Derfoul; K G Keith G Danielson; D J David J Hall; R S Rocky S Tuan
Journal:  Biomaterials       Date:  2005-02       Impact factor: 12.479

Review 7.  Organoids in cancer research.

Authors:  Jarno Drost; Hans Clevers
Journal:  Nat Rev Cancer       Date:  2018-07       Impact factor: 60.716

8.  A randomized, controlled pilot study of autologous CD34+ cell therapy for critical limb ischemia.

Authors:  Douglas W Losordo; Melina R Kibbe; Farrell Mendelsohn; William Marston; Vickie R Driver; Melhem Sharafuddin; Victoria Teodorescu; Bret N Wiechmann; Charles Thompson; Larry Kraiss; Teresa Carman; Suhail Dohad; Paul Huang; Candice E Junge; Kenneth Story; Tara Weistroffer; Tina M Thorne; Meredith Millay; John Paul Runyon; Robert Schainfeld
Journal:  Circ Cardiovasc Interv       Date:  2012-11-27       Impact factor: 6.546

9.  iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-α Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-Induced Cardiomyopathy.

Authors:  Yuelin Zhang; Zhendong Yu; Dan Jiang; Xiaoting Liang; Songyan Liao; Zhao Zhang; Wensheng Yue; Xiang Li; Sin-Ming Chiu; Yuet-Hung Chai; Yingmin Liang; Yenyen Chow; Shuo Han; Aimin Xu; Hung-Fat Tse; Qizhou Lian
Journal:  Stem Cell Reports       Date:  2016-09-15       Impact factor: 7.765

10.  Effect of MSCs and MSC-Derived Extracellular Vesicles on Human Blood Coagulation.

Authors:  Denis N Silachev; Kirill V Goryunov; Margarita A Shpilyuk; Olga S Beznoschenko; Natalya Y Morozova; Elizaveta E Kraevaya; Vasily A Popkov; Irina B Pevzner; Ljubava D Zorova; Ekaterina A Evtushenko; Natalia L Starodubtseva; Alexey S Kononikhin; Anna E Bugrova; Evgeniy G Evtushenko; Egor Y Plotnikov; Dmitry B Zorov; Gennady T Sukhikh
Journal:  Cells       Date:  2019-03-19       Impact factor: 6.600
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  15 in total

Review 1.  Disagreements in the therapeutic use of mesenchymal stem cell-derived secretome.

Authors:  Ferenc Sipos; Györgyi Műzes
Journal:  World J Stem Cells       Date:  2022-06-26       Impact factor: 5.247

Review 2.  Regulation of Inflammatory Cytokine Storms by Mesenchymal Stem Cells.

Authors:  Lu Wang; Yun Li; Moyan Xu; Zihui Deng; Yan Zhao; Mengmeng Yang; Yuyan Liu; Rui Yuan; Yan Sun; Hao Zhang; Heming Wang; Zhirong Qian; Hongjun Kang
Journal:  Front Immunol       Date:  2021-07-29       Impact factor: 8.786

3.  Investigating the effects of IDO1, PTGS2, and TGF-β1 overexpression on immunomodulatory properties of hTERT-MSCs and their extracellular vesicles.

Authors:  Thorsten R Doeppner; Ahmad Reza Bahrami; Azadeh Haghighitalab; Maryam M Matin; Ahmad Amin; Shima Minaee; Hamid Reza Bidkhori
Journal:  Sci Rep       Date:  2021-04-09       Impact factor: 4.379

Review 4.  Dental Mesenchymal Stem Cell Secretome: An Intriguing Approach for Neuroprotection and Neuroregeneration.

Authors:  Agnese Gugliandolo; Emanuela Mazzon
Journal:  Int J Mol Sci       Date:  2021-12-31       Impact factor: 5.923

Review 5.  Clinical Applications of Cell-Scaffold Constructs for Bone Regeneration Therapy.

Authors:  Venkata Suresh Venkataiah; Yoshio Yahata; Akira Kitagawa; Masahiko Inagaki; Yusuke Kakiuchi; Masato Nakano; Shigeto Suzuki; Keisuke Handa; Masahiro Saito
Journal:  Cells       Date:  2021-10-08       Impact factor: 6.600

6.  Safety and efficacy of human umbilical cord mesenchymal stem cells for the treatment of sepsis induced by pneumonia: study protocol for a single-centre, randomised single-blind parallel group trial.

Authors:  Chunxue Wang; Dongyang Zhao; Liang Zheng; Xiaowei Bao; Qian Yang; Sen Jiang; Xiaohui Zhou; Lunxian Tang; Zhongmin Liu
Journal:  BMJ Open       Date:  2022-04-04       Impact factor: 2.692

7.  Adipose-derived mesenchymal stem cells combined with platinum nanoparticles accelerate fracture healing in a rat tibial fracture model.

Authors:  Chuan-Jie Chen; Yuan Feng; Lin Jin; Xin Wang; Li-Xiao-Zi Xu; Jia-Mei Lin; Li-Wen Feng; Li-Na Liu; Zhiyong Hou
Journal:  Ann Transl Med       Date:  2022-04

Review 8.  Oral Bone Tissue Regeneration: Mesenchymal Stem Cells, Secretome, and Biomaterials.

Authors:  Agnese Gugliandolo; Luigia Fonticoli; Oriana Trubiani; Thangavelu S Rajan; Guya D Marconi; Placido Bramanti; Emanuela Mazzon; Jacopo Pizzicannella; Francesca Diomede
Journal:  Int J Mol Sci       Date:  2021-05-15       Impact factor: 5.923

Review 9.  The Cross-Talk between Mesenchymal Stem Cells and Immune Cells in Tissue Repair and Regeneration.

Authors:  Carl Randall Harrell; Valentin Djonov; Vladislav Volarevic
Journal:  Int J Mol Sci       Date:  2021-03-01       Impact factor: 5.923

10.  Potential Anti-Inflammatory Effects of a New Lyophilized Formulation of the Conditioned Medium Derived from Periodontal Ligament Stem Cells.

Authors:  Agnese Gugliandolo; Francesca Diomede; Jacopo Pizzicannella; Luigi Chiricosta; Oriana Trubiani; Emanuela Mazzon
Journal:  Biomedicines       Date:  2022-03-16
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