Literature DB >> 33389301

Comparison of Serum VEGF, IGF-1, and HIF-1α Levels in Children with Autism Spectrum Disorder and Healthy Controls.

Fulya Şimşek1, Ümit Işık2, Evrim Aktepe1, Faruk Kılıç3, Fevziye Burcu Şirin4, Mustafa Bozkurt4.   

Abstract

The aim of this study was to determine whether serum VEGF, IGF-1, and HIF-1α levels differed between Autism Spectrum Disorder (ASD) patients and healthy controls. A total of 40 children with ASD and 40 healthy controls aged 4-12 years were included. Serum levels of VEGF, IGF-1, and HIF-1α were measured using commercial enzyme-linked immunosorbent assay kits. Serum IGF-1 levels were found to be statistically significantly higher in the ASD group than in the control group. Serum HIF-1α levels were borderline significantly lower in the ASD group. There was no statistically significant difference in serum VEGF levels between the two groups. IGF-1 and HIF-1α may play a potential role in the etiopathogenesis of ASD.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

Entities:  

Keywords:  Autism spectrum disorder; HIF-1α; IGF-1; VEGF

Mesh：

Substances：

Year:  2021        PMID： 33389301     DOI： 10.1007/s10803-020-04820-w

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  51 in total

1.  IGF-I supports the survival and/or differentiation of multiple types of central nervous system neurons.

Authors:  D Bozyczko-Coyne; M A Glicksman; J E Prantner; B McKenna; T Connors; C Friedman; M Dasgupta; N T Neff
Journal:  Ann N Y Acad Sci       Date:  1993-08-27       Impact factor: 5.691

2.  Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1.

Authors:  Juan C Chavez; Joseph C LaManna
Journal:  J Neurosci       Date:  2002-10-15       Impact factor: 6.167

3.  Regional white matter development in children with autism spectrum disorders.

Authors:  Dennis P Carmody; Michael Lewis
Journal:  Dev Psychobiol       Date:  2010-12       Impact factor: 3.038

4.  Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome.

Authors:  Paul Ashwood; Paula Krakowiak; Irva Hertz-Picciotto; Robin Hansen; Isaac Pessah; Judy Van de Water
Journal:  Brain Behav Immun       Date:  2010-08-10       Impact factor: 7.217

Review 5.  Vascular endothelial growth factor and the nervous system.

Authors:  A Brockington; C Lewis; S Wharton; P J Shaw
Journal:  Neuropathol Appl Neurobiol       Date:  2004-10       Impact factor: 8.090

6.  Urinary epidermal and insulin-like growth factor excretion in autistic children.

Authors:  B Anlar; F Oktem; B Bakkaloglu; M Haliloglu; H Oguz; F Unal; B Pehlivanturk; B Gokler; C Ozbesler; N Yordam
Journal:  Neuropediatrics       Date:  2007-06       Impact factor: 1.947

7.  Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons.

Authors:  K D Beck; L Powell-Braxton; H R Widmer; J Valverde; F Hefti
Journal:  Neuron       Date:  1995-04       Impact factor: 17.173

8.  Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children.

Authors:  Michael G Chez; Tim Dowling; Pikul B Patel; Pavan Khanna; Matt Kominsky
Journal:  Pediatr Neurol       Date:  2007-06       Impact factor: 3.372

9.  The aberrant behavior checklist: a behavior rating scale for the assessment of treatment effects.

Authors:  M G Aman; N N Singh; A W Stewart; C J Field
Journal:  Am J Ment Defic       Date:  1985-03

10.  Prospective research in infants with mild encephalopathy identified in the first six hours of life: neurodevelopmental outcomes at 18-22 months.

Authors:  Lina F Chalak; Kim-Anh Nguyen; Chatchay Prempunpong; Roy Heyne; Sudhin Thayyil; Seetha Shankaran; Abbot R Laptook; Nancy Rollins; Athina Pappas; Louise Koclas; Birju Shah; Paolo Montaldo; Benyachalee Techasaensiri; Pablo J Sánchez; Guilherme Sant'Anna
Journal:  Pediatr Res       Date:  2018-09-13       Impact factor: 3.756
View more
  2 in total

1.  Serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 in children with autism spectrum disorder.

Authors:  Zheng Li; Gui-Yuan Xiao; Chun-Yan He; Xia Liu; Xin Fan; Yan Zhao; Nian-Rong Wang
Journal:  Zhongguo Dang Dai Er Ke Za Zhi       Date:  2022-02-15

2.  BDNF, proBDNF and IGF-1 serum levels in naïve and medicated subjects with autism.

Authors:  Maria de Los Angeles Robinson-Agramonte; Bernadeta Michalski; Belkis Vidal-Martinez; Leyanis Ramos Hernández; Mabel Whilby Santiesteban; Margaret Fahnestock
Journal:  Sci Rep       Date:  2022-08-12       Impact factor: 4.996
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.