| Literature DB >> 33386464 |
Antoine Berbéri1, Joseph Sabbagh2, Rita Bou Assaf3, Michella Ghassibe-Sabbagh4, Fatima Al-Nemer5, Rania El Majzoub6, Mohammad Fayyad-Kazan7,8, Bassam Badran5.
Abstract
Mesenchymal stem cells, being characterized by high self-renewal capacity and multi-lineage differentiation potential, are widely used in regenerative medicine especially for repair of bone defects in patients with poor bone regenerative capacity. In this study, we aimed to compare the osteogenic potential of human maxillary schneiderian sinus membrane (hMSSM)-derived stem cells versus permanent teeth dental pulp stem cells (DPSCs). Both cells types were cultivated in osteogenic and non-osteogenic inductive media. Alkaline phosphatase (ALP) activity assay and quantitative real-time PCR analysis were carried out to assess osteogenic differentiation. We showed that ALP activity and osteoblastic markers transcription levels were more striking in hMSSM-derived stem cells than DPSCs. Our results highlight hMSSM-derived stem cells as a recommended stem cell type for usage during bone tissue regenerative therapy.Entities:
Keywords: Bone; Dental pulp; Human maxillary schneiderian sinus membrane; Regenerative therapy; stem cells
Year: 2021 PMID： 33386464 DOI： 10.1007/s10561-020-09887-4
Source DB: PubMed Journal: Cell Tissue Bank ISSN： 1389-9333 Impact factor: 1.522