| Literature DB >> 33383027 |
Yu Su1, Yuexiong Yi2, Lu Li1, Changzheng Chen3.
Abstract
The aim of the present study was to investigate the pathogenesis of age-related macular degeneration (AMD) by constructing a regulatory circRNA-miRNA-mRNA network. By adjusting the P value to <0.05 and the absolute log value of fold change to >0.25, 2920 and 1057 differentially expressed mRNAs were identified from GSE50195 and GSE29801, respectively. Based on a literature review, Starbase database analysis, and RNA hybrid assays, we obtained 77 miRNA-mRNA and 331 circRNA-miRNA pairs. After combining these pairs, we constructed a circRNA-miRNA-mRNA network possessing 303 circRNA nodes, 4 miRNA nodes, 51 mRNA nodes, and 408 edges. By utilizing protein-protein network analysis, the MCODE algorithm, and the highest degree of circRNA node, we identified the regulatory axis of hsa_circRNA7329/hsa-miR-9/SCD. Hsa_circRNA7329 may regulate SCD through hsa-miR-9 to promote macrophage-mediated inflammation and pathologic angiogenesis, which lead to AMD development. However, the underlying details require further investigation.Entities:
Keywords: Age-related macular degeneration; Bioinformatics; Neurodegeneration disease; Noncoding RNA
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Year: 2020 PMID： 33383027 DOI： 10.1016/j.exer.2020.108427
Source DB: PubMed Journal: Exp Eye Res ISSN： 0014-4835 Impact factor: 3.467