Literature DB >> 33376803

Consensus Parameter: Research Methodologies to Evaluate Neurodevelopmental Effects of Pubertal Suppression in Transgender Youth.

Diane Chen1,2,3,4, John F Strang5,6,7,8,9, Victoria D Kolbuck1, Stephen M Rosenthal10, Kim Wallen11, Deborah P Waber12,13, Laurence Steinberg14, Cheryl L Sisk15, Judith Ross16,17, Tomas Paus18,19,20, Sven C Mueller21,22, Margaret M McCarthy23, Paul E Micevych24, Carol L Martin25, Baudewijntje P C Kreukels26, Lauren Kenworthy5,6,7,8,9, Megan M Herting27,28, Agneta Herlitz29, Ira R J Hebold Haraldsen30, Ronald Dahl31, Eveline A Crone32, Gordon J Chelune33, Sarah M Burke32, Sheri A Berenbaum34,35, Adriene M Beltz36, Julie Bakker37, Lise Eliot38, Eric Vilain39,40,41, Gregory L Wallace42, Eric E Nelson43,44, Robert Garofalo1,4.   

Abstract

Purpose: Pubertal suppression is standard of care for early pubertal transgender youth to prevent the development of undesired and distressing secondary sex characteristics incongruent with gender identity. Preliminary evidence suggests pubertal suppression improves mental health functioning. Given the widespread changes in brain and cognition that occur during puberty, a critical question is whether this treatment impacts neurodevelopment.
Methods: A Delphi consensus procedure engaged 24 international experts in neurodevelopment, gender development, puberty/adolescence, neuroendocrinology, and statistics/psychometrics to identify priority research methodologies to address the empirical question: is pubertal suppression treatment associated with real-world neurocognitive sequelae? Recommended study approaches reaching 80% consensus were included in the consensus parameter.
Results: The Delphi procedure identified 160 initial expert recommendations, 44 of which ultimately achieved consensus. Consensus study design elements include the following: a minimum of three measurement time points, pubertal staging at baseline, statistical modeling of sex in analyses, use of analytic approaches that account for heterogeneity, and use of multiple comparison groups to minimize the limitations of any one group. Consensus study comparison groups include untreated transgender youth matched on pubertal stage, cisgender (i.e., gender congruent) youth matched on pubertal stage, and an independent sample from a large-scale youth development database. The consensus domains for assessment includes: mental health, executive function/cognitive control, and social awareness/functioning.
Conclusion: An international interdisciplinary team of experts achieved consensus around primary methods and domains for assessing neurodevelopmental effects (i.e., benefits and/or difficulties) of pubertal suppression treatment in transgender youth. © Diane Chen et al. 2020: Published by Mary Ann Liebert, Inc.

Entities:  

Keywords:  Delphi; GnRHa; adolescents; expert consensus; puberty blockers; transgender

Year:  2020        PMID: 33376803      PMCID: PMC7759272          DOI: 10.1089/trgh.2020.0006

Source DB:  PubMed          Journal:  Transgend Health        ISSN: 2380-193X


  62 in total

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Authors:  Kalynn M Schulz; Cheryl L Sisk
Journal:  Mol Cell Endocrinol       Date:  2006-06-05       Impact factor: 4.102

2.  Charting the expansion of strategic exploratory behavior during adolescence.

Authors:  Leah H Somerville; Stephanie F Sasse; Megan C Garrad; Andrew T Drysdale; Nadine Abi Akar; Catherine Insel; Robert C Wilson
Journal:  J Exp Psychol Gen       Date:  2016-12-15

Review 3.  Understanding adolescence as a period of social-affective engagement and goal flexibility.

Authors:  Eveline A Crone; Ronald E Dahl
Journal:  Nat Rev Neurosci       Date:  2012-09       Impact factor: 34.870

4.  Inter-Regional Variations in Gene Expression and Age-Related Cortical Thinning in the Adolescent Brain.

Authors:  Angelita Pui-Yee Wong; Leon French; Gabriel Leonard; Michel Perron; G Bruce Pike; Louis Richer; Suzanne Veillette; Zdenka Pausova; Tomáš Paus
Journal:  Cereb Cortex       Date:  2018-04-01       Impact factor: 5.357

5.  Structural maturation of neural pathways in children and adolescents: in vivo study.

Authors:  T Paus; A Zijdenbos; K Worsley; D L Collins; J Blumenthal; J N Giedd; J L Rapoport; A C Evans
Journal:  Science       Date:  1999-03-19       Impact factor: 47.728

6.  Early Medical Treatment of Children and Adolescents With Gender Dysphoria: An Empirical Ethical Study.

Authors:  Lieke Josephina Jeanne Johanna Vrouenraets; A Miranda Fredriks; Sabine E Hannema; Peggy T Cohen-Kettenis; Martine C de Vries
Journal:  J Adolesc Health       Date:  2015-06-25       Impact factor: 5.012

7.  Social cognitive development during adolescence.

Authors:  Suparna Choudhury; Sarah-Jayne Blakemore; Tony Charman
Journal:  Soc Cogn Affect Neurosci       Date:  2006-12       Impact factor: 3.436

Review 8.  The amygdala: an agent of change in adolescent neural networks.

Authors:  K Suzanne Scherf; Joshua M Smyth; Mauricio R Delgado
Journal:  Horm Behav       Date:  2013-06-10       Impact factor: 3.587

Review 9.  A role for synaptic plasticity in the adolescent development of executive function.

Authors:  L D Selemon
Journal:  Transl Psychiatry       Date:  2013-03-05       Impact factor: 6.222

10.  Key Brain Network Nodes Show Differential Cognitive Relevance and Developmental Trajectories during Childhood and Adolescence.

Authors:  Knut K Kolskår; Dag Alnæs; Tobias Kaufmann; Geneviève Richard; Anne-Marthe Sanders; Kristine M Ulrichsen; Torgeir Moberget; Ole A Andreassen; Jan E Nordvik; Lars T Westlye
Journal:  eNeuro       Date:  2018-07-11
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  6 in total

1.  Standards of Care for the Health of Transgender and Gender Diverse People, Version 8.

Authors:  E Coleman; A E Radix; W P Bouman; G R Brown; A L C de Vries; M B Deutsch; R Ettner; L Fraser; M Goodman; J Green; A B Hancock; T W Johnson; D H Karasic; G A Knudson; S F Leibowitz; H F L Meyer-Bahlburg; S J Monstrey; J Motmans; L Nahata; T O Nieder; S L Reisner; C Richards; L S Schechter; V Tangpricha; A C Tishelman; M A A Van Trotsenburg; S Winter; K Ducheny; N J Adams; T M Adrián; L R Allen; D Azul; H Bagga; K Başar; D S Bathory; J J Belinky; D R Berg; J U Berli; R O Bluebond-Langner; M-B Bouman; M L Bowers; P J Brassard; J Byrne; L Capitán; C J Cargill; J M Carswell; S C Chang; G Chelvakumar; T Corneil; K B Dalke; G De Cuypere; E de Vries; M Den Heijer; A H Devor; C Dhejne; A D'Marco; E K Edmiston; L Edwards-Leeper; R Ehrbar; D Ehrensaft; J Eisfeld; E Elaut; L Erickson-Schroth; J L Feldman; A D Fisher; M M Garcia; L Gijs; S E Green; B P Hall; T L D Hardy; M S Irwig; L A Jacobs; A C Janssen; K Johnson; D T Klink; B P C Kreukels; L E Kuper; E J Kvach; M A Malouf; R Massey; T Mazur; C McLachlan; S D Morrison; S W Mosser; P M Neira; U Nygren; J M Oates; J Obedin-Maliver; G Pagkalos; J Patton; N Phanuphak; K Rachlin; T Reed; G N Rider; J Ristori; S Robbins-Cherry; S A Roberts; K A Rodriguez-Wallberg; S M Rosenthal; K Sabir; J D Safer; A I Scheim; L J Seal; T J Sehoole; K Spencer; C St Amand; T D Steensma; J F Strang; G B Taylor; K Tilleman; G G T'Sjoen; L N Vala; N M Van Mello; J F Veale; J A Vencill; B Vincent; L M Wesp; M A West; J Arcelus
Journal:  Int J Transgend Health       Date:  2022-09-06

2.  Medical decision-making competence regarding puberty suppression: perceptions of transgender adolescents, their parents and clinicians.

Authors:  Lieke Josephina Jeanne Johanna Vrouenraets; Annelou L C de Vries; Marijn Arnoldussen; Sabine E Hannema; Ramón J L Lindauer; Martine C de Vries; Irma M Hein
Journal:  Eur Child Adolesc Psychiatry       Date:  2022-09-17       Impact factor: 5.349

3.  Bell v Tavistock and Portman NHS Foundation Trust [2020] EWHC 3274: Weighing current knowledge and uncertainties in decisions about gender-related treatment for transgender adolescents.

Authors:  Annelou L C de Vries; Christina Richards; Amy C Tishelman; Joz Motmans; Sabine E Hannema; Jamison Green; Stephen M Rosenthal
Journal:  Int J Transgend Health       Date:  2021-04-05

4.  Association between pre-treatment IQ and educational achievement after gender-affirming treatment including puberty suppression in transgender adolescents.

Authors:  Marijn Arnoldussen; Evelien C Hooijman; Baudewijntje Pc Kreukels; Annelou Lc de Vries
Journal:  Clin Child Psychol Psychiatry       Date:  2022-05-31       Impact factor: 2.087

5.  Transgender Youth Executive Functioning: Relationships with Anxiety Symptoms, Autism Spectrum Disorder, and Gender-Affirming Medical Treatment Status.

Authors:  John F Strang; Diane Chen; Eric Nelson; Scott F Leibowitz; Leena Nahata; Laura G Anthony; Amber Song; Connor Grannis; Elizabeth Graham; Shane Henise; Eric Vilain; Eleonora Sadikova; Andrew Freeman; Cara Pugliese; Ayesha Khawaja; Tekla Maisashvili; Michael Mancilla; Lauren Kenworthy
Journal:  Child Psychiatry Hum Dev       Date:  2021-06-19

6.  Structural, Functional, and Metabolic Brain Differences as a Function of Gender Identity or Sexual Orientation: A Systematic Review of the Human Neuroimaging Literature.

Authors:  Alberto Frigerio; Lucia Ballerini; Maria Valdés Hernández
Journal:  Arch Sex Behav       Date:  2021-05-06
  6 in total

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