Nourhan Hisham Shady1, Khayrya A Youssif2, Ahmed M Sayed3, Lassaad Belbahri4, Tomasz Oszako5, Hossam M Hassan3,6, Usama Ramadan Abdelmohsen1,7. 1. Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone, P.O. Box 61111, New Minia City, Minia 61519, Egypt. 2. Department of Pharmacognosy, Faculty of Pharmacy, Modern University for Technology and Information, Cairo 11865, Egypt. 3. Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt. 4. Laboratory of Soil Biology, University of Neuchatel, 2000 Neuchatel, Switzerland. 5. Departement of Forest Protection, Forest Research Institute, 05-090 Sękocin Stary, Poland. 6. Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt. 7. Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Abstract
The acute respiratory syndrome caused by the novel coronavirus (SARS-CoV-2) caused severe panic all over the world. The coronavirus (COVID-19) outbreak has already brought massive human suffering and major economic disruption and unfortunately, there is no specific treatment for COVID-19 so far. Herbal medicines and purified natural products can provide a rich resource for novel antiviral drugs. Therefore, in this review, we focused on the sterols and triterpenes as potential candidates derived from natural sources with well-reported in vitro efficacy against numerous types of viruses. Moreover, we compiled from these reviewed compounds a library of 162 sterols and triterpenes that was subjected to a computer-aided virtual screening against the active sites of the recently reported SARS-CoV-2 protein targets. Interestingly, the results suggested some compounds as potential drug candidates for the development of anti-SARS-CoV-2 therapeutics.
The acute respiratory syndrome caused by the pan class="Species">novel coronavirus (SARS-CoV-2) caused severe panic all over the world. The coronavirus (COVID-19) outbreak has already brought massive human suffering and major economic disruption and unfortunately, there is no specific treatment for COVID-19 so far. Herbal medicines and purified natural products can provide a rich resource for novel antiviral drugs. Therefore, in this review, we focused on the sterols and triterpenes as potential candidates derived from natural sources with well-reported in vitro efficacy against numerous types of viruses. Moreover, we compiled from these reviewed compounds a library of 162 sterols and triterpenes that was subjected to a computer-aided virtual screening against the active sites of the recently reported SARS-CoV-2 protein targets. Interestingly, the results suggested some compounds as potential drug candidates for the development of anti-SARS-CoV-2 therapeutics.
Authors: Nourhan Hisham Shady; Raya Soltane; Sherif A Maher; Entesar Ali Saber; Mahmoud A Elrehany; Yaser A Mostafa; Ahmed M Sayed; Usama Ramadan Abdelmohsen Journal: Plants (Basel) Date: 2022-05-24
Authors: Raha Orfali; Mostafa E Rateb; Hossam M Hassan; Mona Alonazi; Mokhtar R Gomaa; Noura Mahrous; Mohamed GabAllah; Ahmed Kandeil; Shagufta Perveen; Usama Ramadan Abdelmohsen; Ahmed M Sayed Journal: Antibiotics (Basel) Date: 2021-04-11
Authors: Ahmed E Allam; Yhiya Amen; Ahmed Ashour; Hamdy K Assaf; Heba Ali Hassan; Islam M Abdel-Rahman; Ahmed M Sayed; Kuniyoshi Shimizu Journal: RSC Adv Date: 2021-06-24 Impact factor: 4.036
Authors: Eva E Rufino-Palomares; Amalia Pérez-Jiménez; Leticia García-Salguero; Khalida Mokhtari; Fernando J Reyes-Zurita; Juan Peragón-Sánchez; José A Lupiáñez Journal: Molecules Date: 2022-04-05 Impact factor: 4.411
Authors: Raya Soltane; Amani Chrouda; Ahmed Mostafa; Ahmed A Al-Karmalawy; Karim Chouaïb; Abdelwaheb Dhahri; Rami Adel Pashameah; Ahlam Alasiri; Omnia Kutkat; Mahmoud Shehata; Hichem Ben Jannet; Jawhar Gharbi; Mohamed A Ali Journal: Pathogens Date: 2021-05-19
Authors: Nourhan Hisham Shady; Alaa M Hayallah; Mamdouh F A Mohamed; Mohammed M Ghoneim; Garri Chilingaryan; Mohammad M Al-Sanea; Mostafa A Fouad; Mohamed Salah Kamel; Usama Ramadan Abdelmohsen Journal: Molecules Date: 2021-06-21 Impact factor: 4.411