Literature DB >> 33371734

Comparison of Clinical Outcome following Cartilage Repair for Patients with Underlying Varus Deformity with or without Additional High Tibial Osteotomy: A Propensity Score-Matched Study Based on the German Cartilage Registry (KnorpelRegister DGOU).

Svea Faber1, Peter Angele2,3,4,5, Johannes Zellner6, Gerrit Bode2,3,4,7, Alfred Hochrein1, Philipp Niemeyer1,7.   

Abstract

BACKGROUND: Even though realignment procedures have gained popularity as concomitant techniques in cartilage repair approaches with underlying malalignment, the clinical efficacy has not been proven to full extent.
METHODS: Out of 5474 patients from the German Cartilage Registry, 788 patients with focal cartilage defects on the medial femoral condyle having received either no accompanying surgery or high tibial osteotomy (HTO) were identified. After a 1:1 propensity score matching, outcome of 440 patients was evaluated using KOOS (Knee Injury and Osteoarthritis Outcome Score), VAS (visual analogue scale), and satisfaction during the 3-year follow-up.
RESULTS: Patients having received a concomitant HTO had significantly higher postoperative KOOS values (12 months: 67.26 ± 15.69 vs.75.10 ± 16.12, P = 0.001; 24 months: 67.14 ± 23.85 vs. 77.11 ± 16.50, P = 0.010; 36 months: 74.40 ± 16.57 vs. 81.75 ± 14.22, P = 0.023) and lower pain levels (6 months: 3.43 ± 2.18 vs. 2.89 ± 2.15, P = 0.009; 12 months: 3.64 ± 2.20 vs. 2.17 ± 1.96, P < 0.001; 24 months: 4.20 ± 3.12 vs. 2.94 ± 2.45, P = 0.005; 36 months: 3.20 ± 2.18 vs. 2.02 ± 1.98, P = 0.003). One and 3 years postoperatively, concomitant HTO led to significantly higher satisfaction in patients. These advantages of accompanying HTO were also seen in the group of patients with a varus deformity of 5° or more, in which pain levels without concomitant HTO even increased during the 3-year follow-up.
CONCLUSION: The results of the present study underline the importance and safety of concomitant HTO in patients with cartilage defects and varus deformity. HTO should therefore be considered and recommended generously in patients with focal cartilage defects of the medial femoral condyle and varus deformity.

Entities:  

Keywords:  cartilage repair; cartilage transplantation; grafts; microfracture; osteotomy; procedures; repair

Mesh:

Year:  2020        PMID: 33371734      PMCID: PMC8808839          DOI: 10.1177/1947603520982347

Source DB:  PubMed          Journal:  Cartilage        ISSN: 1947-6035            Impact factor:   3.117


  33 in total

1.  Survivorship of high tibial osteotomy in the treatment of osteoarthritis of the knee: Finnish registry-based study of 3195 knees.

Authors:  T T Niinimäki; A Eskelinen; B S Mann; M Junnila; P Ohtonen; J Leppilahti
Journal:  J Bone Joint Surg Br       Date:  2012-11

2.  Comparative outcomes of open-wedge high tibial osteotomy with platelet-rich plasma alone or in combination with mesenchymal stem cell treatment: a prospective study.

Authors:  Yong-Gon Koh; Oh-Ryong Kwon; Yong-Sang Kim; Yun-Jin Choi
Journal:  Arthroscopy       Date:  2014-08-06       Impact factor: 4.772

Review 3.  Patellar chondral defects: a review of a challenging entity.

Authors:  George Mouzopoulos; Carlo Borbon; Rainer Siebold
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2011-05-24       Impact factor: 4.342

4.  Full-Thickness Cartilage Defects Are Important Independent Predictive Factors for Progression to Total Knee Arthroplasty in Older Adults with Minimal to Moderate Osteoarthritis: Data from the Osteoarthritis Initiative.

Authors:  Joshua S Everhart; Moneer M Abouljoud; J Caid Kirven; David C Flanigan
Journal:  J Bone Joint Surg Am       Date:  2019-01-02       Impact factor: 5.284

5.  Treatment of symptomatic cartilage defects of the knee: characterized chondrocyte implantation results in better clinical outcome at 36 months in a randomized trial compared to microfracture.

Authors:  Daniel B F Saris; Johan Vanlauwe; Jan Victor; Karl Fredrik Almqvist; Rene Verdonk; Johan Bellemans; Frank P Luyten
Journal:  Am J Sports Med       Date:  2009-10-21       Impact factor: 6.202

6.  High tibial osteotomy for unloading osteochondral defects in the medial compartment of the knee.

Authors:  Curtis Mina; William E Garrett; Ricardo Pietrobon; Richard Glisson; Laurence Higgins
Journal:  Am J Sports Med       Date:  2008-04-15       Impact factor: 6.202

7.  The effects of valgus medial opening wedge high tibial osteotomy on articular cartilage pressure of the knee: a biomechanical study.

Authors:  Jens Dominik Agneskirchner; Christof Hurschler; Christiane D Wrann; Philipp Lobenhoffer
Journal:  Arthroscopy       Date:  2007-08       Impact factor: 4.772

8.  Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation.

Authors:  M Brittberg; A Lindahl; A Nilsson; C Ohlsson; O Isaksson; L Peterson
Journal:  N Engl J Med       Date:  1994-10-06       Impact factor: 91.245

9.  Clinical outcome after treatment of single and multiple cartilage defects by autologous matrix-induced chondrogenesis.

Authors:  Rimtautas Gudas; Justinas Mačiulaitis; Mantas Staškūnas; Alfredas Smailys
Journal:  J Orthop Surg (Hong Kong)       Date:  2019 May-Aug       Impact factor: 1.118

10.  Matrix-Associated Autologous Chondrocyte Implantation Is an Effective Treatment at Midterm Follow-up in Adolescents and Young Adults.

Authors:  Arnd Hoburg; Ingo Löer; Konrad Körsmeier; Rainer Siebold; Philipp Niemeyer; Stefan Fickert; Klaus Ruhnau
Journal:  Orthop J Sports Med       Date:  2019-04-25
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  4 in total

Review 1.  [Quality in sports orthopedics and traumatology: more than just return to play].

Authors:  Wolf Petersen; Sebastian Bierke; Martin Häner
Journal:  Chirurg       Date:  2021-07-12       Impact factor: 0.955

2.  Current practice of concomitant surgeries in cartilage repair of the femorotibial compartment of the knee: baseline data of 4968 consecutive patients from the German cartilage registry (KnorpelRegister DGOU).

Authors:  Johannes Zellner; Svea Faber; Gunter Spahn; Wolfgang Zinser; Philipp Niemeyer; Peter Angele
Journal:  Arch Orthop Trauma Surg       Date:  2021-07-29       Impact factor: 3.067

3.  Autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction: similar short-term results in comparison with isolated cartilage repair in ligament intact joints.

Authors:  Julian Mehl; Matthias Feucht; Andrea Achtnich; Andreas B Imhoff; Philipp Niemeyer; Peter Angele; Wolfgang Zinser; Gunter Spahn; Ingo Loer; Heino Kniffler; Gunnar Schauf; Andreas Schmitt
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2021-10-09       Impact factor: 4.114

4.  The German Arthroscopy Registry DART: what has happened after 5 years?

Authors:  Maximilian Hinz; Christoph Lutter; Ralf Mueller-Rath; Philipp Niemeyer; Oliver Miltner; Thomas Tischer
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2022-09-25       Impact factor: 4.114

  4 in total

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