Literature DB >> 33371306

Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue.

Agnieszka Arthur1,2, Stan Gronthos1,2.   

Abstract

There has been an escalation in reports over the last decade examining the efficacy of bone marrow derived mesenchymal stem/stromal cells (BMSC) in bone tissue engineering and regenerative medicine-based applications. The multipotent differentiation potential, myelosupportive capacity, anti-inflammatory and immune-modulatory properties of BMSC underpins their versatile nature as therapeutic agents. This review addresses the current limitations and challenges of exogenous autologous and allogeneic BMSC based regenerative skeletal therapies in combination with bioactive molecules, cellular derivatives, genetic manipulation, biocompatible hydrogels, solid and composite scaffolds. The review highlights the current approaches and recent developments in utilizing endogenous BMSC activation or exogenous BMSC for the repair of long bone and vertebrae fractures due to osteoporosis or trauma. Current advances employing BMSC based therapies for bone regeneration of craniofacial defects is also discussed. Moreover, this review discusses the latest developments utilizing BMSC therapies in the preclinical and clinical settings, including the treatment of bone related diseases such as Osteogenesis Imperfecta.

Entities:  

Keywords:  biomaterials; bone marrow mesenchymal stem cells; bone marrow microenvironment; scaffolds; skeletal tissue regeneration; tissue engineering

Mesh：

Year:  2020        PMID： 33371306      PMCID： PMC7767389          DOI： 10.3390/ijms21249759

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  187 in total

1.  Molecular and cellular characterisation of highly purified stromal stem cells derived from human bone marrow.

Authors:  Stan Gronthos; Andrew C W Zannettino; Shelley J Hay; Songtao Shi; Stephen E Graves; Angela Kortesidis; Paul J Simmons
Journal:  J Cell Sci       Date:  2003-05-01       Impact factor: 5.285

2.  Bone Marrow Transplantation for Treatment of the Col1a2+/G610C Osteogenesis Imperfecta Mouse Model.

Authors:  Lucinda R Lee; Lauren Peacock; Samantha L Ginn; Laurence C Cantrill; Tegan L Cheng; David G Little; Craig F Munns; Aaron Schindeler
Journal:  Calcif Tissue Int       Date:  2018-12-08       Impact factor: 4.333

3.  Translation of a standardized manufacturing protocol for mesenchymal stromal cells: A systematic comparison of validation and manufacturing data.

Authors:  Markus Thomas Rojewski; Ramin Lotfi; Cecilie Gjerde; Kamal Mustafa; Elena Veronesi; Aymen B Ahmed; Markus Wiesneth; Sixten Körper; Luc Sensebé; Pierre Layrolle; Sølve Hellem; Hubert Schrezenmeier
Journal:  Cytotherapy       Date:  2019-03-27       Impact factor: 5.414

Review 4.  Concise review: the surface markers and identity of human mesenchymal stem cells.

Authors:  Feng-Juan Lv; Rocky S Tuan; Kenneth M C Cheung; Victor Y L Leung
Journal:  Stem Cells       Date:  2014-06       Impact factor: 6.277

5.  Recruitment of exogenous mesenchymal stem cells in mandibular distraction osteogenesis by the stromal cell-derived factor-1/chemokine receptor-4 pathway in rats.

Authors:  Jian Cao; Lei Wang; Zhao-jie Du; Peng Liu; Ya-bo Zhang; Jian-fu Sui; Yan-pu Liu; De-lin Lei
Journal:  Br J Oral Maxillofac Surg       Date:  2013-06-06       Impact factor: 1.651

Review 6.  Diabetes and Its Effect on Bone and Fracture Healing.

Authors:  Hongli Jiao; E Xiao; Dana T Graves
Journal:  Curr Osteoporos Rep       Date:  2015-10       Impact factor: 5.096

7.  MSC surface markers (CD44, CD73, and CD90) can identify human MSC-derived extracellular vesicles by conventional flow cytometry.

Authors:  Teresa L Ramos; Luis Ignacio Sánchez-Abarca; Sandra Muntión; Silvia Preciado; Noemí Puig; Guillermo López-Ruano; Ángel Hernández-Hernández; Alba Redondo; Rebeca Ortega; Concepción Rodríguez; Fermín Sánchez-Guijo; Consuelo del Cañizo
Journal:  Cell Commun Signal       Date:  2016-01-12       Impact factor: 5.712

8.  Crude Fucoidan Extracts Impair Angiogenesis in Models Relevant for Bone Regeneration and Osteosarcoma via Reduction of VEGF and SDF-1.

Authors:  Fanlu Wang; Harald Schmidt; Dijana Pavleska; Thees Wermann; Andreas Seekamp; Sabine Fuchs
Journal:  Mar Drugs       Date:  2017-06-20       Impact factor: 5.118

Review 9.  Bone fracture healing in mechanobiological modeling: A review of principles and methods.

Authors:  Mohammad S Ghiasi; Jason Chen; Ashkan Vaziri; Edward K Rodriguez; Ara Nazarian
Journal:  Bone Rep       Date:  2017-03-16

10.  Engineered scaffolds based on mesenchymal stem cells/preosteoclasts extracellular matrix promote bone regeneration.

Authors:  Rui Dong; Yun Bai; Jingjin Dai; Moyuan Deng; Chunrong Zhao; Zhansong Tian; Fanchun Zeng; Wanyuan Liang; Lanyi Liu; Shiwu Dong
Journal:  J Tissue Eng       Date:  2020-06-07       Impact factor: 7.813
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  29 in total

1.  Mouse Periosteal Cell Culture, in vitro Differentiation, and in vivo Transplantationin Tibial Fractures.

Authors:  Simon Perrin; Anais Julien; Oriane Duchamp de Lageneste; Rana Abou-Khalil; Céline Colnot
Journal:  Bio Protoc       Date:  2021-08-05

2.  Embryonic stem cell-derived mesenchymal stem cells alleviate skeletal muscle injury induced by acute compartment syndrome.

Authors:  Xiangkang Jiang; Jingyuan Yang; Fei Liu; Jiawei Tao; Jiefeng Xu; Mao Zhang
Journal:  Stem Cell Res Ther       Date:  2022-07-15       Impact factor: 8.079

3.  αCGRP Regulates Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells Through ERK1/2 and p38 MAPK Signaling Pathways.

Authors:  Yixuan Jiang; Na Xin; Yi Xiong; Yanjun Guo; Ying Yuan; Qin Zhang; Ping Gong
Journal:  Cell Transplant       Date:  2022 Jan-Dec       Impact factor: 4.139

Review 4.  The Emerging Role of Non-Coding RNAs in Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells.

Authors:  Xiaoying Chen; Wei Xie; Ming Zhang; Yuhan Shi; Shaofen Xu; Haoyu Cheng; Lihong Wu; Janak L Pathak; Zhichao Zheng
Journal:  Front Cell Dev Biol       Date:  2022-05-16

5.  Adipose-Derived Mesenchymal Stem Cells Reprogram M1 Macrophage Metabolism via PHD2/HIF-1α Pathway in Colitis Mice.

Authors:  Yin Yuan; Shuo Ni; Aoxiang Zhuge; Lanjuan Li; Bo Li
Journal:  Front Immunol       Date:  2022-06-10       Impact factor: 8.786

Review 6.  "Genetic scissors" CRISPR/Cas9 genome editing cutting-edge biocarrier technology for bone and cartilage repair.

Authors:  Chao Li; Yawei Du; Tongtong Zhang; Haoran Wang; Zhiyong Hou; Yingze Zhang; Wenguo Cui; Wei Chen
Journal:  Bioact Mater       Date:  2022-10-07

7.  Eradication of specific donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance therapeutic values.

Authors:  Chunxue Zhang; Liqiang Zhou; Zhen Wang; Wenxia Gao; Wei Chen; Huina Zhang; Bo Jing; Xu Zhu; Lei Chen; Changhong Zheng; Kaiyan Shi; Li Wu; Liming Cheng; Kunshan Zhang; Yi Eve Sun
Journal:  Cell Death Dis       Date:  2021-04-06       Impact factor: 8.469

8.  Bone mesenchymal stem cell-derived exosomal microRNA-7-5p inhibits progression of acute myeloid leukemia by targeting OSBPL11.

Authors:  Duanfeng Jiang; Xin Wu; Xiaoying Sun; Wei Tan; Xin Dai; Youbang Xie; Ashuai Du; Qiangqiang Zhao
Journal:  J Nanobiotechnology       Date:  2022-01-10       Impact factor: 10.435

9.  Clinical, Histological, and Scintigraphic Comparative Study of the Use of Mandibular Bone Marrow and Peripheral Blood in Bone Neoformation.

Authors:  Paulo José Pasquali; Rodrigo André Dall'Agnol; Lucas Garcia Rezende; Elizabeth Ferreira Martinez
Journal:  Int J Dent       Date:  2021-12-31

10.  Evaluation of Human Bone Marrow Mesenchymal Stromal Cell (MSC) Functions on a Biomorphic Rattan-Wood-Derived Scaffold: A Comparison between Cultured and Uncultured MSCs.

Authors:  Payal Ganguly; Jehan J El-Jawhari; James Vun; Peter V Giannoudis; Elena A Jones
Journal:  Bioengineering (Basel)       Date:  2021-12-21
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