| Literature DB >> 36263098 |
Chao Li1,2, Yawei Du2, Tongtong Zhang1, Haoran Wang1,2, Zhiyong Hou1, Yingze Zhang1, Wenguo Cui2, Wei Chen1.
Abstract
CRISPR/Cas9 is a revolutionary genome editing technology with the tremendous advantages such as precisely targeting/shearing ability, low cost and convenient operation, becoming an efficient and indispensable tool in biological research. As a disruptive technique, CRISPR/Cas9 genome editing has a great potential to realize a future breakthrough in the clinical bone and cartilage repairing as well. This review highlights the research status of CRISPR/Cas9 system in bone and cartilage repair, illustrates its mechanism for promoting osteogenesis and chondrogenesis, and explores the development tendency of CRISPR/Cas9 in bone and cartilage repair to overcome the current limitations.Entities:
Keywords: Bone repair; CRISPR/Cas9; Cartilage repair; Genome editing
Year: 2022 PMID： 36263098 PMCID： PMC9554751 DOI： 10.1016/j.bioactmat.2022.09.026
Source DB: PubMed Journal: Bioact Mater ISSN： 2452-199X