Jolanda Sabatino1,2,3, Salvatore De Rosa1,2, Isabella Leo1, Carmen Spaccarotella1,2, Annalisa Mongiardo1, Alberto Polimeni1,2, Sabato Sorrentino1,2, Giovanni Di Salvo3,4, Ciro Indolfi1,2,5. 1. Division of Cardiology, Department of Medical and Surgical Sciences, "Magna Graecia" University, Catanzaro (CZ), Italy. 2. Cardiovascular Research Center, "Magna Graecia" University, Catanzaro (CZ), Italy. 3. Department of Paediatric Cardiology, Royal Brompton Hospital, London, United Kingdom. 4. Department of Women's and Children's Health, University of Padua, Padua, Italy. 5. Mediterranea Cardiocentro, Naples (NA), Italy.
Abstract
BACKGROUND: During ischemia a close relationship exists between sub-endocardial blood flow and myocardial function. Strain parameters can capture an impairment of regional longitudinal function but are load dependent. Recently, a novel non-invasive method to calculate Myocardial Work (MW) showed a strong correlation with invasive work measurements. Our aim was to investigate the ability of non-invasive MW indices to identify the ischaemic risk area during transient acute coronary occlusion (TACO). METHODS AND RESULTS: The study population comprises 50 individuals with critical coronary stenosis (CCS). Echocardiography recordings were obtained before coronary angiography, during TACO and after revascularization to measure global longitudinal strain (GLS), Myocardial Work Index (MWI), Myocardial Constructive Work (MCW), Myocardial Wasted work (MWW), Myocardial work efficiency (MWE). Compared to baseline, we found a significant reduction of GLS (p = 0.005), MWI, MCW and MWE (p<0.001) during TACO. CONCLUSIONS: The non-invasive measurement of MW parameters is a sensitive and early marker of myocardial ischemia during TACO.
BACKGROUND: During ischemia a close relationship exists between sub-endocardial blood flow and myocardial function. Strain parameters can capture an impairment of regional longitudinal function but are load dependent. Recently, a novel non-invasive method to calculate Myocardial Work (MW) showed a strong correlation with invasive work measurements. Our aim was to investigate the ability of non-invasive MW indices to identify the ischaemic risk area during transient acute coronary occlusion (TACO). METHODS AND RESULTS: The study population comprises 50 individuals with critical coronary stenosis (CCS). Echocardiography recordings were obtained before coronary angiography, during TACO and after revascularization to measure global longitudinal strain (GLS), Myocardial Work Index (MWI), Myocardial Constructive Work (MCW), Myocardial Wasted work (MWW), Myocardial work efficiency (MWE). Compared to baseline, we found a significant reduction of GLS (p = 0.005), MWI, MCW and MWE (p<0.001) during TACO. CONCLUSIONS: The non-invasive measurement of MW parameters is a sensitive and early marker of myocardial ischemia during TACO.
Authors: Kristoffer Russell; Morten Eriksen; Lars Aaberge; Nils Wilhelmsen; Helge Skulstad; Ola Gjesdal; Thor Edvardsen; Otto A Smiseth Journal: Am J Physiol Heart Circ Physiol Date: 2013-07-26 Impact factor: 4.733
Authors: Salvatore De Rosa; Jolanda Sabatino; Antonio Strangio; Isabella Leo; Letizia Rosa Romano; Carmen Anna Spaccarotella; Annalisa Mongiardo; Alberto Polimeni; Sabato Sorrentino; Ciro Indolfi Journal: J Clin Med Date: 2022-01-29 Impact factor: 4.241
Authors: Jolanda Sabatino; Isabella Leo; Antonio Strangio; Sabrina La Bella; Nunzia Borrelli; Martina Avesani; Manjit Josen; Josefa Paredes; Enrico Piccinelli; Domenico Sirico; Valeria Pergola; Alain Fraisse; Salvatore De Rosa; Ciro Indolfi; Giovanni Di Salvo Journal: Front Cardiovasc Med Date: 2022-04-25
Authors: Jolanda Sabatino; Salvatore De Rosa; Isabella Leo; Antonio Strangio; Sabrina La Bella; Sabato Sorrentino; Annalisa Mongiardo; Carmen Spaccarotella; Alberto Polimeni; Ciro Indolfi Journal: Open Heart Date: 2021-07