BACKGROUND: Left ventricular noncompaction cardiomyopathy (LVNC) is associated with poor clinical outcome in childhood. Standard diagnostic criteria are still controversial, especially in young patients. Recent studies in adults demonstrated that left ventricular (LV) twist is abnormal in LVNC, but it has not been investigated in pediatric patients to date. Our aim was to assess LV cardiac mechanics, LV twist, and the prevalence of rigid body rotation, using 2-dimensional speckle tracking echocardiography, in young patients with LVNC and LV hypertrabeculation. METHODS: Forty-seven children (age range: 0-18 years) were assessed for suspected LVNC. All patients underwent 2-dimensional speckle tracking echocardiography and cardiovascular magnetic resonance imaging at 1.5 Tesla (T). Twenty-three patients fulfilled the cardiovascular magnetic resonance imaging diagnostic criteria for LVNC (LVNC group), while the remaining 24 did not and were included in the LV hypertrabeculation group. Forty-seven age- and sex-matched healthy volunteers were used as controls. RESULTS: The average LV twist was significantly reduced in LVNC compared with control and LV hypertrabeculation. Rigid body rotation was recognized in 13 (56%) children with LVNC and in 1 (4%) child with LV hypertrabeculation and a strong family history for LVNC. Multivariable analysis demonstrated that LV twist is an independent predictor of LVNC ( P=0.006; coefficient=0.462). The receiver operating characteristics curve showed that LV twist had optimal predictive value to discriminate patients with LVNC (cutoff value <5.8°; sensitivity, 82%; specificity, 92%; area under the curve=0.914). CONCLUSIONS: LV twist has good predictive value in diagnosing LVNC in young patients. Our findings strongly support the routine use of 2-dimensional speckle tracking echocardiography in the evaluation of young patients with suspected LVNC.
BACKGROUND:Left ventricular noncompaction cardiomyopathy (LVNC) is associated with poor clinical outcome in childhood. Standard diagnostic criteria are still controversial, especially in young patients. Recent studies in adults demonstrated that left ventricular (LV) twist is abnormal in LVNC, but it has not been investigated in pediatric patients to date. Our aim was to assess LV cardiac mechanics, LVtwist, and the prevalence of rigid body rotation, using 2-dimensional speckle tracking echocardiography, in young patients with LVNC and LV hypertrabeculation. METHODS: Forty-seven children (age range: 0-18 years) were assessed for suspected LVNC. All patients underwent 2-dimensional speckle tracking echocardiography and cardiovascular magnetic resonance imaging at 1.5 Tesla (T). Twenty-three patients fulfilled the cardiovascular magnetic resonance imaging diagnostic criteria for LVNC (LVNC group), while the remaining 24 did not and were included in the LV hypertrabeculation group. Forty-seven age- and sex-matched healthy volunteers were used as controls. RESULTS: The average LVtwist was significantly reduced in LVNC compared with control and LV hypertrabeculation. Rigid body rotation was recognized in 13 (56%) children with LVNC and in 1 (4%) child with LV hypertrabeculation and a strong family history for LVNC. Multivariable analysis demonstrated that LVtwist is an independent predictor of LVNC ( P=0.006; coefficient=0.462). The receiver operating characteristics curve showed that LVtwist had optimal predictive value to discriminate patients with LVNC (cutoff value <5.8°; sensitivity, 82%; specificity, 92%; area under the curve=0.914). CONCLUSIONS:LVtwist has good predictive value in diagnosing LVNC in young patients. Our findings strongly support the routine use of 2-dimensional speckle tracking echocardiography in the evaluation of young patients with suspected LVNC.
Entities:
Keywords:
cardiomyopathies; echocardiography; magnetic resonance imaging; pediatrics
Authors: Jolanda Sabatino; Salvatore De Rosa; Isabella Leo; Carmen Spaccarotella; Annalisa Mongiardo; Alberto Polimeni; Sabato Sorrentino; Giovanni Di Salvo; Ciro Indolfi Journal: PLoS One Date: 2020-12-28 Impact factor: 3.240
Authors: Marcelo Dantas Tavares de Melo; Jose de Arimatéia Batista Araujo-Filho; José Raimundo Barbosa; Camila Rocon; Carlos Danilo Miranda Regis; Alex Dos Santos Felix; Roberto Kalil Filho; Edimar Alcides Bocchi; Ludhmila Abrahão Hajjar; Mahdi Tabassian; Jan D'hooge; Vera Maria Cury Salemi Journal: PLoS One Date: 2021-11-29 Impact factor: 3.240
Authors: Nadya Al-Wakeel-Marquard; Franziska Seidel; Jirko Kühnisch; Titus Kuehne; Felix Berger; Daniel R Messroghli; Sabine Klaassen Journal: Front Cardiovasc Med Date: 2022-02-17
Authors: Jolanda Sabatino; Isabella Leo; Antonio Strangio; Sabrina La Bella; Nunzia Borrelli; Martina Avesani; Manjit Josen; Josefa Paredes; Enrico Piccinelli; Domenico Sirico; Valeria Pergola; Alain Fraisse; Salvatore De Rosa; Ciro Indolfi; Giovanni Di Salvo Journal: Front Cardiovasc Med Date: 2022-04-25
Authors: Guido E Pieles; Jaime Alkon; Cedric Manlhiot; Chun-Po Steve Fan; Caroline Kinnear; Leland N Benson; Seema Mital; Mark K Friedberg Journal: Pediatr Res Date: 2020-05-06 Impact factor: 3.756
Authors: Sylvia Krupickova; Suzan Hatipoglu; Giovanni DiSalvo; Inga Voges; Daniel Redfearn; Sandrine Foldvari; Christian Eichhorn; Sian Chivers; Filippo Puricelli; Grazia Delle-Donne; Courtney Barth; Dudley J Pennell; Sanjay K Prasad; Piers E F Daubeney Journal: J Cardiovasc Magn Reson Date: 2021-07-08 Impact factor: 5.364