| Literature DB >> 3336034 |
C B Chapleo1, P L Myers, A C Smith, M R Stillings, I F Tulloch, D S Walter.
Abstract
Two different structural types of 2-aryl-1,3,4-thiadiazole amidines were synthesized and evaluated for anticonvulsant activity. Enhancement of the inherent anticonvulsant activity therein and separation of this activity from the accompanying sedative action of these compounds were attempted. The most potent compounds occurred in the 2-(trifluoromethyl)phenyl series of type 3 amidines, but they also possessed a relatively high level of neurotoxicity and sedation as demonstrated in the rotorod test.Entities:
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Year: 1988 PMID： 3336034 DOI： 10.1021/jm00396a004
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446