Literature DB >> 24974242

A convenient four-component one-pot synthesis of 2-amino-1,3,4-thiadiazoles in water.

Peng Liu1, Ao-Ze Su, Yuan-Qiang Wang, Ze-Mei Ge, Tie-Ming Cheng, Run-Tao Li.   

Abstract

A novel four-component one-pot approach for the synthesis of 2-amino-1,3,4-thiadiazoles from primary amines, carbon disulfide, hydrazine, and acyl chlorides has been developed. A series of 5-substituted-2-amino-1,3,4-thiadiazoles were synthesized in medium-to-good yields utilizing this newly developed method.

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Year:  2014        PMID： 24974242     DOI： 10.1007/s11030-014-9526-6

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  33 in total

1.  Some hypotensive thiadiazoles.

Authors:  A M Grant; S V Krees; A B Mauger; W J Rzeszotarski; F W Wolff
Journal:  J Med Chem       Date:  1972-10       Impact factor: 7.446

2.  Synthesis and hypoglycemic activity of 3-aryl(or pyridyl)-5-alkyl(or aryl)amino-1,3,4-thiadiazoles and some sulfonylurea derivatives of 4H-1,2,4-triazoles.

Authors:  M Y Mhasalkar; M H Shah; P D Pilankar; S T Nikam; K G Anantanarayanan; C V Deliwala
Journal:  J Med Chem       Date:  1971-10       Impact factor: 7.446

3.  Antitumor activity of 5-substituted 2-acylamino-1,3,4-thiadiazoles against transplantable rodent tumors.

Authors:  K Miyamoto; R Koshiura; M Mori; H Yokoi; C Mori; T Hasegawa; K Takatori
Journal:  Chem Pharm Bull (Tokyo)       Date:  1985-11       Impact factor: 1.645

4.  Carbonic anhydrase inhibitors: ureido and thioureido derivatives of aromatic sulfonamides possessing increased affinities for isozyme I. A novel route to 2,5-disubstituted-1,3,4-thiadiazoles via thioureas, and their interaction with isozymes I, II and IV.

Authors:  A Scozzafava; C T Supuran
Journal:  J Enzyme Inhib       Date:  1998-04

5.  Synthesis and antimicrobial activity of new 1,2,4-triazole and 1,3,4-thiadiazole derivatives.

Authors:  Tijen Onkol; Deniz S Doğruer; Leyla Uzun; Selcen Adak; Semiha Ozkan; M Fethi Sahin
Journal:  J Enzyme Inhib Med Chem       Date:  2008-04       Impact factor: 5.051

6.  Nitroimidazolyl-1,3,4-thiadiazole-based anti-leishmanial agents: synthesis and in vitro biological evaluation.

Authors:  Fatemeh Poorrajab; Sussan Kabudanian Ardestani; Saeed Emami; Mina Behrouzi-Fardmoghadam; Abbas Shafiee; Alireza Foroumadi
Journal:  Eur J Med Chem       Date:  2008-04-09       Impact factor: 6.514

7.  Synthesis and antiproliferative activity of some 5-substituted 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles.

Authors:  Joanna Matysiak; Anna Nasulewicz; Marzena Pełczyńska; Marta Switalska; Iwona Jaroszewicz; Adam Opolski
Journal:  Eur J Med Chem       Date:  2006-03-03       Impact factor: 6.514

8.  1,3,4-Oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid: synthesis and preliminary evaluation of biological properties.

Authors:  Harish Kumar; Sadique A Javed; Suroor A Khan; Mohammad Amir
Journal:  Eur J Med Chem       Date:  2008-02-08       Impact factor: 6.514

9.  1,3,4-Oxadiazole, 1,3,4-thiadiazole, and 1,2,4-triazole analogs of the fenamates: in vitro inhibition of cyclooxygenase and 5-lipoxygenase activities.

Authors:  D H Boschelli; D T Connor; D A Bornemeier; R D Dyer; J A Kennedy; P J Kuipers; G C Okonkwo; D J Schrier; C D Wright
Journal:  J Med Chem       Date:  1993-06-25       Impact factor: 7.446

10.  Synthesis and antiviral activity of 5‑(4‑chlorophenyl)-1,3,4-thiadiazole sulfonamides.

Authors:  Zhuo Chen; Weiming Xu; Keming Liu; Song Yang; Huitao Fan; Pinaki S Bhadury; De-Yu Hu; Yuping Zhang
Journal:  Molecules       Date:  2010-12-09       Impact factor: 4.411
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