Jeong Min Seong1, Chang Eun Park2, Mi Young Gi3, Ju Ae Cha4, Eun Young Jung5, Jun Ho Lee6, Hyun Ho Sung7, Seung Bum Yang8, Bae Lee9, Jae Heon Lim10, Hyun Yoon11. 1. Department of Dental Hygiene, College of Health Science, Kangwon National University, Samcheok-si, Gangwon-do, 25949, South Korea. 2. Department of Biomedical Laboratory Science, Namseoul University, Cheonan-si, Chungcheongnam-do, 31020, South Korea. 3. Department of Nursing, Christian College of Nursing, Gwangju, 61662, South Korea. 4. Department of Nursing, Chunnam Technouniversity, Gokseong-gun, Jeollanam-do, 57500, South Korea. 5. Department of Health & Medical Administration, Chosun College of Science & Technology, Gwangju, South Korea. 6. Department of Clinical Laboratory Science, Wonkwang Health Science University, Iksan-si, Jeollabuk-do, 54538, South Korea. 7. Department of Clinical Laboratory Science, Dongnam Health University, Suwonsi, Gyeonggi-do, 16328, South Korea. 8. Department of Medical Non-commissioned Officer, Wonkwang Health Science University, 514, Iksan-daero, Iksan-si, Jeollabuk-do, 54538, South Korea. 9. Department of Early Childhood Education, Wonkwang Health Science University, 514, Iksan-daero, Iksan-si, Jeollabuk-do, 54538, South Korea. 10. Department of Physiotherapy, Wonkwang Health Science University, 345-13, Sinyong-dong, Iksan-si, Jeollabuk-do, 54538, South Korea. 11. Department of Clinical Laboratory Science, Wonkwang Health Science University, Iksan-si, Jeollabuk-do, 54538, South Korea. Electronic address: yh9074@yahoo.co.kr.
Abstract
AIMS: The present study assesses the relationship between uric acid (UA) and lipid accumulation product index (LAP) by gender among Korean adults. METHODS: Data from 5670 subjects (2463 men and 3207 women) in the Korean National Health and Nutrition Examination Survey (KNHANES VII-1) 2016 were analyzed. LAP was divided into four quartiles (Q1-Q4). RESULTS: There were several key findings. Compared with Q1, in the overall population, the odds ratios (ORs) of hyperuricemia (UA ≥ 7.0 mg/dL in men or UA ≥ 6.0 mg/dL in women) were significantly higher in Q2 [1.847 (95% confidence interval [CI], 1.325-2.575)], Q3 [3.050 (95% CI, 2.216-4.198)], and Q4 of LAP [6.367 (95% CI, 4.658-8.704)]. In men, the ORs of hyperuricemia were significantly higher in Q2 [1.658 (95% CI, 1.162-2.367)], Q3 [2.341 (95% CI, 1.656-3.308)], and Q4 [4.633 (95% CI, 3.290-6.525)] than Q1. In women, the ORs of hyperuricemia were significantly higher in Q2 [2.254 (95% CI, 1.085-4.680)], Q3 [5.402 (95% CI, 2.735-10.668)], and Q4 [11.025 (95% CI, 5.620-21.628)] than Q1. In addition, UA levels were positively associated with LAP level in men (r = 0.218; p < 0.001), women (r = 0.261; p < 0.001), and the overall population (r = 0.260; p < 0.001). CONCLUSIONS: Hyperuricemia was positively associated with LAP in Korean men and women.
AIMS: The present study assesses the relationship between uric acid (UA) and lipid accumulation product index (LAP) by gender among Korean adults. METHODS: Data from 5670 subjects (2463 men and 3207 women) in the Korean National Health and Nutrition Examination Survey (KNHANES VII-1) 2016 were analyzed. LAP was divided into four quartiles (Q1-Q4). RESULTS: There were several key findings. Compared with Q1, in the overall population, the odds ratios (ORs) of hyperuricemia (UA ≥ 7.0 mg/dL in men or UA ≥ 6.0 mg/dL in women) were significantly higher in Q2 [1.847 (95% confidence interval [CI], 1.325-2.575)], Q3 [3.050 (95% CI, 2.216-4.198)], and Q4 of LAP [6.367 (95% CI, 4.658-8.704)]. In men, the ORs of hyperuricemia were significantly higher in Q2 [1.658 (95% CI, 1.162-2.367)], Q3 [2.341 (95% CI, 1.656-3.308)], and Q4 [4.633 (95% CI, 3.290-6.525)] than Q1. In women, the ORs of hyperuricemia were significantly higher in Q2 [2.254 (95% CI, 1.085-4.680)], Q3 [5.402 (95% CI, 2.735-10.668)], and Q4 [11.025 (95% CI, 5.620-21.628)] than Q1. In addition, UA levels were positively associated with LAP level in men (r = 0.218; p < 0.001), women (r = 0.261; p < 0.001), and the overall population (r = 0.260; p < 0.001). CONCLUSIONS:Hyperuricemia was positively associated with LAP in Korean men and women.
Authors: Ferid Abdulhafiz; Mohd Farhan Hanif Reduan; Zulhazman Hamzah; Zulhisyam Abdul Kari; Mahmoud A O Dawood; Arifullah Mohammed Journal: Saudi J Biol Sci Date: 2022-01-29 Impact factor: 4.052