| Literature DB >> 33357841 |
Antônia Carla de Jesus Oliveira1, Luíse Lopes Chaves1, Fábio de Oliveira Silva Ribeiro2, Laís Ramos Monteiro de Lima3, Thaisa Cardoso Oliveira1, Fátima García-Villén4, César Viseras5, Regina C M de Paula3, Pedro José Rolim-Neto6, Fernando Hallwass7, Edson C Silva-Filho8, Durcilene Alves da Silva2, José Lamartine Soares-Sobrinho9, Mônica Felts de La Roca Soares1.
Abstract
Chemical modification of polysaccharides is an important approach for their transformation into customized matrices that suit different applications. Microwave irradiation (MW) has been used to catalyze chemical reactions. This study developed a method of MW-initiated synthesis for the production of phthalated cashew gum (Phat-CG). The structural characteristics and physicochemical properties of the modified biopolymers were investigated by FTIR, GPC, 1H NMR, relaxometry, elemental analysis, thermal analysis, XRD, degree of substitution, and solubility. Phat-CG was used as a matrix for drug delivery systems using benznidazole (BNZ) as a model drug. BNZ is used in the pharmacotherapy of Chagas disease. The nanoparticles were characterized by size, PDI, zeta potential, AFM, and in vitro release. The nanoparticles had a size of 288.8 nm, PDI of 0.27, and zeta potential of -31.8 mV. The results showed that Phat-CG has interesting and promising properties as a new alternative for improving the treatment of Chagas disease.Entities:
Keywords: Benznidazole; Chemical modification; Microwave irradiation; Polymeric nanoparticles; Polysaccharides
Mesh：
Substances：
Year: 2020 PMID： 33357841 DOI： 10.1016/j.carbpol.2020.117226
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381