Christian Agudelo1, Wassim Tarraf2, Benson Wu3, Douglas M Wallace1, Sanjay R Patel4, Susan Redline5, Sonya Kaur1, Martha Daviglus6, Phyllis C Zee7, Guido Simonelli8, Yasmin Mossavar-Rahmani9, Daniela Sotres-Alvarez10, Donglin Zeng10, Linda C Gallo11, Hector M González3, Alberto R Ramos1. 1. Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA. 2. Department of Healthcare Sciences and Institute of Gerontology, Wayne State University, Detroit, Michigan, USA. 3. Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego School of Medicine, San Diego, California, USA. 4. Center for Sleep and Cardiovascular Outcomes Research, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. 5. Departments of Medicine and Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. 6. Institute for Minority Health Research, University of Illinois at Chicago College of Medicine, Chicago, Illinois, USA. 7. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. 8. Center for Advanced Research in Sleep Medicine, Hopital du Sacre-Coeur de Montreal, CIUSSS du Nord-de-l'Ile-de-Montréal, Montréal, Canada. 9. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA. 10. Department of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, USA. 11. Department of Psychology and South Bay Latino Research Center, San Diego State University, San Diego, California, USA.
Abstract
INTRODUCTION: We determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults. METHODS: We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates. RESULTS: Longer sleep-onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep-onset latency was also cross-sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change. CONCLUSION: In a cohort of mostly middle-aged Hispanic/Latinos, actigraphy-derived sleep-onset latency predicted 7-year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.
INTRODUCTION: We determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults. METHODS: We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates. RESULTS: Longer sleep-onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep-onset latency was also cross-sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change. CONCLUSION: In a cohort of mostly middle-aged Hispanic/Latinos, actigraphy-derived sleep-onset latency predicted 7-year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.
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