Yue Leng1, Susan Redline2, Katie L Stone3, Sonia Ancoli-Israel4, Kristine Yaffe5. 1. Department of Psychiatry, University of California, San Francisco, CA, USA. Electronic address: yue.leng@ucsf.edu. 2. Departments of Medicine, Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 3. Research Institute, California Pacific Medical Center, San Francisco, CA, USA. 4. Department of Psychiatry, University of California, San Diego, CA, USA. 5. Departments of Psychiatry, Neurology, and Epidemiology, University of California, San Francisco, San Francisco VA Medical Center, San Francisco, CA, USA.
Abstract
INTRODUCTION: Little is known about the longitudinal association between napping and cognitive impairment in older adults. METHODS: We used wrist actigraphy to measure naps in 2751 community-dwelling older men. Cognition was assessed repeatedly over 12 years, and clinically significant cognitive impairment was determined by physician diagnosis, Alzheimer's medication use or a significant cognitive decline. RESULTS: After adjustment for all covariates, men with longer napping duration had greater cognitive decline and higher risk of cognitive impairment. Men who napped for ≥120 min/day (vs. <30 min/day) were 66% more likely to develop cognitive impairment (odds ratio = 1.66, 95% CI: 1.09-2.54) in 12 years. Further adjustment for nighttime sleep quality did not appreciably alter the results. The association between napping and cognitive impairment was more pronounced among those with higher sleep efficiency and average sleep duration. DISCUSSION: Napping might be useful as an early marker of cognitive impairment in the elderly, and its cognitive effects may differ by nighttime sleep.
INTRODUCTION: Little is known about the longitudinal association between napping and cognitive impairment in older adults. METHODS: We used wrist actigraphy to measure naps in 2751 community-dwelling older men. Cognition was assessed repeatedly over 12 years, and clinically significant cognitive impairment was determined by physician diagnosis, Alzheimer's medication use or a significant cognitive decline. RESULTS: After adjustment for all covariates, men with longer napping duration had greater cognitive decline and higher risk of cognitive impairment. Men who napped for ≥120 min/day (vs. <30 min/day) were 66% more likely to develop cognitive impairment (odds ratio = 1.66, 95% CI: 1.09-2.54) in 12 years. Further adjustment for nighttime sleep quality did not appreciably alter the results. The association between napping and cognitive impairment was more pronounced among those with higher sleep efficiency and average sleep duration. DISCUSSION: Napping might be useful as an early marker of cognitive impairment in the elderly, and its cognitive effects may differ by nighttime sleep.
Authors: Qian Xiao; Joshua N Sampson; Andrea Z LaCroix; Aladdin H Shadyab; Jamie M Zeitzer; Sonia Ancoli-Israel; Kristin Yaffe; Katie Stone Journal: J Gerontol A Biol Sci Med Sci Date: 2022-02-03 Impact factor: 6.591
Authors: Jun Y Oh; Christine M Walsh; Kamalini Ranasinghe; Mihovil Mladinov; Felipe L Pereira; Cathrine Petersen; Neus Falgàs; Leslie Yack; Tia Lamore; Rakin Nasar; Caroline Lew; Song Li; Thomas Metzler; Quentin Coppola; Natalie Pandher; Michael Le; Hilary W Heuer; Helmut Heinsen; Salvatore Spina; William W Seeley; Joel Kramer; Gil D Rabinovici; Adam L Boxer; Bruce L Miller; Keith Vossel; Thomas C Neylan; Lea T Grinberg Journal: JAMA Neurol Date: 2022-05-01 Impact factor: 29.907
Authors: Meredith L Wallace; Lan Yu; Daniel J Buysse; Katie L Stone; Susan Redline; Stephen F Smagula; Marcia L Stefanick; Donna Kritz-Silverstein; Martica H Hall Journal: Sleep Date: 2021-02-12 Impact factor: 5.849
Authors: Joseph R Winer; Allison Morehouse; Laura Fenton; Theresa M Harrison; Lylian Ayangma; Mark Reed; Samika Kumar; Suzanne L Baker; William J Jagust; Matthew P Walker Journal: J Neurosci Date: 2021-07-21 Impact factor: 6.167
Authors: Emma L Anderson; Rebecca C Richmond; Samuel E Jones; Gibran Hemani; Kaitlin H Wade; Hassan S Dashti; Jacqueline M Lane; Heming Wang; Richa Saxena; Ben Brumpton; Roxanna Korologou-Linden; Jonas B Nielsen; Bjørn Olav Åsvold; Gonçalo Abecasis; Elizabeth Coulthard; Simon D Kyle; Robin N Beaumont; Jessica Tyrrell; Timothy M Frayling; Marcus R Munafò; Andrew R Wood; Yoav Ben-Shlomo; Laura D Howe; Deborah A Lawlor; Michael N Weedon; George Davey Smith Journal: Int J Epidemiol Date: 2021-07-09 Impact factor: 7.196