| Literature DB >> 33348921 |
Adelina Lombrea1, Diana Antal2, Florina Ardelean2, Stefana Avram1,3, Ioana Zinuca Pavel1,3, Lavinia Vlaia4,5, Ana-Maria Mut4,5, Zorita Diaconeasa6, Cristina Adriana Dehelean3,7, Codruta Soica3,8, Corina Danciu1,3.
Abstract
Origanum vulgare L. is a widely used aromatic plant, especially due to its content in essential oil, mainly rich in carvacrol and thymol. The ethnopharmacological uses of Origanum vulgare L. essential oil (OEO) comprise digestive, respiratory, or dermatological disorders. The review focuses on the increasing number of recent studies investigating several biological activities of OEO. The bioactivities are in tight relation to the phytochemical profile of the essential oil, and also depend on taxonomic, climatic, and geographical characteristics of the plant material. The antibacterial, antifungal, antiparasitic, antioxidant, anti-inflammatory, antitumor, skin disorders beneficial effects, next to antihyperglycemic and anti-Alzheimer activities were reported and confirmed in multiple studies. Moreover, recent studies indicate a positive impact on skin disorders of OEO formulated as nanocarrier systems in order to improve its bioavailability and, thus, enhancing its therapeutic benefits. The review brings an up to date regarding the phytochemistry and bioactivity of Origanum vulgare L. essential oil, underlining also the most successful pharmaceutical formulation used for skin disorders.Entities:
Keywords: Origanum vulgare L.; bioactivity; essential oil; pharmaceutical formulation; phytochemistry
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Year: 2020 PMID： 33348921 PMCID： PMC7765853 DOI： 10.3390/ijms21249653
Source DB: PubMed Journal: Int J Mol Sci ISSN： 1422-0067 Impact factor: 5.923