Literature DB >> 33340449

The immune landscape in tuberculosis reveals populations linked to disease and latency.

Ekaterina Esaulova1, Shibali Das2, Dhiraj Kumar Singh3, Jose Alberto Choreño-Parra4, Amanda Swain1, Laura Arthur1, Javier Rangel-Moreno5, Mushtaq Ahmed2, Bindu Singh3, Ananya Gupta2, Luis Alejandro Fernández-López4, Maria de la Luz Garcia-Hernandez5, Allison Bucsan6, Chivonne Moodley6, Smriti Mehra6, Ethel García-Latorre7, Joaquin Zuniga8, Jeffrey Atkinson9, Deepak Kaushal10, Maxim N Artyomov11, Shabaana A Khader12.   

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) latently infects approximately one-fourth of the world's population. The immune mechanisms that govern progression from latent (LTBI) to active pulmonary TB (PTB) remain poorly defined. Experimentally Mtb-infected non-human primates (NHP) mirror the disease observed in humans and recapitulate both PTB and LTBI. We characterized the lung immune landscape in NHPs with LTBI and PTB using high-throughput technologies. Three defining features of PTB in macaque lungs include the influx of plasmacytoid dendritic cells (pDCs), an Interferon (IFN)-responsive macrophage population, and activated T cell responses. In contrast, a CD27+ Natural killer (NK) cell subset accumulated in the lungs of LTBI macaques. This NK cell population was also detected in the circulation of LTBI individuals. This comprehensive analysis of the lung immune landscape will improve the understanding of TB immunopathogenesis, providing potential targets for therapies and vaccines for TB control.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  NK cells; granulomas; immune protection; lung; pDCs; single cell technologies; tuberculosis; type I IFNs

Mesh：

Year:  2020        PMID： 33340449      PMCID： PMC7878437          DOI： 10.1016/j.chom.2020.11.013

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   31.316


  59 in total

1.  IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung.

Authors:  Shabaana A Khader; Lokesh Guglani; Javier Rangel-Moreno; Radha Gopal; Beth A Fallert Junecko; Jeffrey J Fountain; Cynthia Martino; John E Pearl; Michael Tighe; Yin-yao Lin; Samantha Slight; Jay K Kolls; Todd A Reinhart; Troy D Randall; Andrea M Cooper
Journal:  J Immunol       Date:  2011-10-14       Impact factor: 5.422

2.  Bacillus Calmette-Guérin (BCG) Revaccination of Adults with Latent Mycobacterium tuberculosis Infection Induces Long-Lived BCG-Reactive NK Cell Responses.

Authors:  Mark Hatherill; Thomas J Scriba; Sara Suliman; Hennie Geldenhuys; John L Johnson; Jane E Hughes; Erica Smit; Melissa Murphy; Asma Toefy; Lesedi Lerumo; Christiaan Hopley; Bernadette Pienaar; Phalkun Chheng; Elisa Nemes; Daniel F Hoft; Willem A Hanekom; W Henry Boom
Journal:  J Immunol       Date:  2016-07-13       Impact factor: 5.422

3.  Stereological analysis of bacterial load and lung lesions in nonhuman primates (rhesus macaques) experimentally infected with Mycobacterium tuberculosis.

Authors:  Paul A Luciw; Karen L Oslund; Xiao-Wei Yang; Lourdes Adamson; Resmi Ravindran; Don R Canfield; Ross Tarara; Linda Hirst; Miles Christensen; Nicholas W Lerche; Heather Offenstein; David Lewinsohn; Frank Ventimiglia; Laurie Brignolo; Erik R Wisner; Dallas M Hyde
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2011-08-26       Impact factor: 5.464

4.  Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells.

Authors:  Emma M Carrington; Jian-Guo Zhang; Robyn M Sutherland; Ingela B Vikstrom; Jamie L Brady; Priscilla Soo; David Vremec; Cody Allison; Erinna F Lee; W Douglas Fairlie; Philippe Bouillet; Stephanie Grabow; Eleonora Ottina; Marco J Herold; Marc Pellegrini; David C S Huang; David M Tarlinton; Andreas Strasser; Andrew M Lew; Yifan Zhan
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-16       Impact factor: 11.205

5.  viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia.

Authors:  El-ad David Amir; Kara L Davis; Michelle D Tadmor; Erin F Simonds; Jacob H Levine; Sean C Bendall; Daniel K Shenfeld; Smita Krishnaswamy; Garry P Nolan; Dana Pe'er
Journal:  Nat Biotechnol       Date:  2013-05-19       Impact factor: 54.908

Review 6.  The End of the Binary Era: Revisiting the Spectrum of Tuberculosis.

Authors:  Philana Ling Lin; JoAnne L Flynn
Journal:  J Immunol       Date:  2018-11-01       Impact factor: 5.422

7.  TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis.

Authors:  Andre Bafica; Charles A Scanga; Carl G Feng; Cynthia Leifer; Allen Cheever; Alan Sher
Journal:  J Exp Med       Date:  2005-12-19       Impact factor: 14.307

8.  Mucosal vaccination with attenuated Mycobacterium tuberculosis induces strong central memory responses and protects against tuberculosis.

Authors:  Deepak Kaushal; Taylor W Foreman; Uma S Gautam; Xavier Alvarez; Toidi Adekambi; Javier Rangel-Moreno; Nadia A Golden; Ann-Marie F Johnson; Bonnie L Phillips; Muhammad H Ahsan; Kasi E Russell-Lodrigue; Lara A Doyle; Chad J Roy; Peter J Didier; James L Blanchard; Jyothi Rengarajan; Andrew A Lackner; Shabaana A Khader; Smriti Mehra
Journal:  Nat Commun       Date:  2015-10-13       Impact factor: 14.919

9.  Tissue-specific regulation of CXCL9/10/11 chemokines in keratinocytes: Implications for oral inflammatory disease.

Authors:  Alison Marshall; Antonio Celentano; Nicola Cirillo; Michael McCullough; Stephen Porter
Journal:  PLoS One       Date:  2017-03-02       Impact factor: 3.240

Review 10.  The current state of animal models and genomic approaches towards identifying and validating molecular determinants of Mycobacterium tuberculosis infection and tuberculosis disease.

Authors:  Allison N Bucsan; Smriti Mehra; Shabaana A Khader; Deepak Kaushal
Journal:  Pathog Dis       Date:  2019-06-01       Impact factor: 3.166
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  25 in total

1.  TOLLIP Optimizes Dendritic Cell Maturation to Lipopolysaccharide and Mycobacterium tuberculosis.

Authors:  Sambasivan Venkatasubramanian; Robyn Pryor; Courtney Plumlee; Sarah B Cohen; Jason D Simmons; Alexander J Warr; Andrew D Graustein; Aparajita Saha; Thomas R Hawn; Kevin B Urdahl; Javeed A Shah
Journal:  J Immunol       Date:  2022-07-08       Impact factor: 5.426

2.  Novel In Silico Insights into Rv1417 and Rv2617c as Potential Protein Targets: The Importance of the Medium on the Structural Interactions with Exported Repetitive Protein (Erp) of Mycobacterium tuberculosis.

Authors:  Margot Paco-Chipana; Camilo Febres-Molina; Jorge Alberto Aguilar-Pineda; Badhin Gómez
Journal:  Polymers (Basel)       Date:  2022-06-25       Impact factor: 4.967

3.  Peripheral Blood Markers Correlate with the Progression of Active Tuberculosis Relative to Latent Control of Mycobacterium tuberculosis Infection in Macaques.

Authors:  Maya Gough; Dhiraj K Singh; Chivonne Moodley; Tianhua Niu; Nadia A Golden; Deepak Kaushal; Smriti Mehra
Journal:  Pathogens       Date:  2022-05-05

4.  Spatiotemporal mapping of the leprosy granuloma landscape.

Authors:  Marco P La Manna; Francesco Dieli; Nadia Caccamo
Journal:  Cell Mol Immunol       Date:  2022-01-07       Impact factor: 22.096

5.  A non-canonical type 2 immune response coordinates tuberculous granuloma formation and epithelialization.

Authors:  Mark R Cronan; Erika J Hughes; W Jared Brewer; Gopinath Viswanathan; Emily G Hunt; Bindu Singh; Smriti Mehra; Stefan H Oehlers; Simon G Gregory; Deepak Kaushal; David M Tobin
Journal:  Cell       Date:  2021-03-23       Impact factor: 41.582

6.  Phenotype of Peripheral NK Cells in Latent, Active, and Meningeal Tuberculosis.

Authors:  José Alberto Choreño-Parra; Luis Armando Jiménez-Álvarez; Ellis Daniela Maldonado-Díaz; Graciela Cárdenas; Luis Alejandro Fernández-Lopez; José Luis Soto-Hernandez; Marcela Muñoz-Torrico; Gustavo Ramírez-Martínez; Alfredo Cruz-Lagunas; Armando Vega-López; María Lilia Domínguez-López; Carlos Sánchez-Garibay; Parménides Guadarrama-Ortíz; Silvia Giono; Luis Antonio Jiménez-Zamudio; Shabaana A Khader; Ethel A García-Latorre; Citlaltepetl Salinas-Lara; Joaquín Zúñiga
Journal:  J Immunol Res       Date:  2021-04-27       Impact factor: 4.818

7.  Myeloid cell interferon responses correlate with clearance of SARS-CoV-2.

Authors:  Dhiraj Singh; Ekaterina Aladyeva; Shibali Das; Bindu Singh; Ekaterina Esaulova; Amanda Swain; Mushtaq Ahmed; Journey Cole; Chivonne Moodley; Smriti Mehra; Larry Schlesinger; Maxim Artyomov; Shabaana Khader; Deepak Kaushal
Journal:  Res Sq       Date:  2021-07-15

8.  Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity.

Authors:  Hongwei Su; Kan Lin; Divya Tiwari; Claire Healy; Carolina Trujillo; Yao Liu; Thomas R Ioerger; Dirk Schnappinger; Sabine Ehrt
Journal:  J Exp Med       Date:  2021-07-16       Impact factor: 14.307

9.  The cellular architecture of the antimicrobial response network in human leprosy granulomas.

Authors:  Feiyang Ma; Travis K Hughes; Rosane M B Teles; Priscila R Andrade; Bruno J de Andrade Silva; Olesya Plazyo; Lam C Tsoi; Tran Do; Marc H Wadsworth; Aislyn Oulee; Maria Teresa Ochoa; Euzenir N Sarno; M Luisa Iruela-Arispe; Eynav Klechevsky; Bryan Bryson; Alex K Shalek; Barry R Bloom; Johann E Gudjonsson; Matteo Pellegrini; Robert L Modlin
Journal:  Nat Immunol       Date:  2021-06-24       Impact factor: 31.250

10.  Single cell analysis of M. tuberculosis phenotype and macrophage lineages in the infected lung.

Authors:  Davide Pisu; Lu Huang; Vipin Narang; Monique Theriault; Gabrielle Lê-Bury; Bernett Lee; Agnes E Lakudzala; David T Mzinza; David V Mhango; Steven C Mitini-Nkhoma; Kondwani C Jambo; Amit Singhal; Henry C Mwandumba; David G Russell
Journal:  J Exp Med       Date:  2021-07-22       Impact factor: 14.307
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