Literature DB >> 33339824

Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients.

Ali Bohlok1, Peter Vermeulen2,3, Sophia Leduc4, Emily Latacz2, Lara Botzenhart3, François Richard4, Maxim De Schepper4, Tatjana Geukens4, Valerio Lucidi5, Michail Ignatiadis6, Philippe Aftimos7, Christos Sotiriou8, Martine Piccart6, Alain Hendlisz9, Steven Van Laere2, Luc Dirix2,3, Jean-Christophe Noël10, Elia Biganzoli11, Denis Larsimont12, Christine Desmedt13, Vincent Donckier14.   

Abstract

Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic surgery. Survival analyses showed that the presence of a desmoplastic HGP in the liver metastases (a rim of fibrous tissue separating cancer cells from the liver parenchyma, present in 20 (56%) patients) is independently associated with favorable progression-free and overall survival when compared with the replacement HGP (cancer cells growing into the liver parenchyma, present in 16 (44%) patients).

Entities:  

Year:  2020        PMID： 33339824     DOI： 10.1038/s41523-020-00209-1

Source DB:  PubMed          Journal:  NPJ Breast Cancer        ISSN： 2374-4677


  2 in total

1.  Histopathological growth patterns of colorectal liver metastasis exhibit little heterogeneity and can be determined with a high diagnostic accuracy.

Authors:  D J Höppener; P M H Nierop; E Herpel; N N Rahbari; M Doukas; P B Vermeulen; D J Grünhagen; C Verhoef
Journal:  Clin Exp Metastasis       Date:  2019-05-27       Impact factor: 5.150

2.  ASO Author Reflections: The Prognostic Value of Time to Metastasis in Colorectal Liver Metastasis.

Authors:  Diederik J Höppener; Cornelis Verhoef
Journal:  Ann Surg Oncol       Date:  2019-10-23       Impact factor: 5.344
  2 in total
  6 in total

1.  Histopathological growth patterns of resected non-colorectal, non-neuroendocrine liver metastases: a retrospective multicenter study.

Authors:  Yannick Meyer; Ali Bohlok; Diederik Höppener; Boris Galjart; Michail Doukas; Dirk J Grünhagen; Anaïs Labar; Valerio Lucidi; Peter B Vermeulen; Cornelis Verhoef; Vincent Donckier
Journal:  Clin Exp Metastasis       Date:  2022-02-06       Impact factor: 5.150

Review 2.  CT, MRI, and radiomics studies of liver metastasis histopathological growth patterns: an up-to-date review.

Authors:  Shenglin Li; Zhengxiao Li; Xiaoyu Huang; Peng Zhang; Juan Deng; Xianwang Liu; Caiqiang Xue; Wenjuan Zhang; Junlin Zhou
Journal:  Abdom Radiol (NY)       Date:  2022-07-27

Review 3.  Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights.

Authors:  Emily Latacz; Diederik Höppener; Ali Bohlok; Vincent Donckier; Peter M Siegel; Raymond Barnhill; Marco Gerling; Cornelis Verhoef; Peter B Vermeulen; Sophia Leduc; Sébastien Tabariès; Carlos Fernández Moro; Claire Lugassy; Hanna Nyström; Béla Bozóky; Giuseppe Floris; Natalie Geyer; Pnina Brodt; Laura Llado; Laura Van Mileghem; Maxim De Schepper; Ali W Majeed; Anthoula Lazaris; Piet Dirix; Qianni Zhang; Stéphanie K Petrillo; Sophie Vankerckhove; Ines Joye; Yannick Meyer; Alexander Gregorieff; Nuria Ruiz Roig; Fernando Vidal-Vanaclocha; Larsimont Denis; Rui Caetano Oliveira; Peter Metrakos; Dirk J Grünhagen; Iris D Nagtegaal; David G Mollevi; William R Jarnagin; Michael I D'Angelica; Andrew R Reynolds; Michail Doukas; Christine Desmedt; Luc Dirix
Journal:  Br J Cancer       Date:  2022-06-01       Impact factor: 9.075

4.  Growth Pattern of Hepatic Metastasis as a Prognostic Index Reflecting Liver Metastasis-Associated Survival in Breast Cancer Liver Metastasis.

Authors:  Jieun Lee; Moonhyung Choi; Seungyeon Joe; Kabsoo Shin; Sung-Hak Lee; Ahwon Lee
Journal:  J Clin Med       Date:  2022-05-18       Impact factor: 4.964

Review 5.  Different Forms of Tumor Vascularization and Their Clinical Implications Focusing on Vessel Co-option in Colorectal Cancer Liver Metastases.

Authors:  Gwendolyn Haas; Shuang Fan; Michael Ghadimi; Tiago De Oliveira; Lena-Christin Conradi
Journal:  Front Cell Dev Biol       Date:  2021-04-12

6.  Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern.

Authors:  Sébastien Tabariès; Matthew G Annis; Anthoula Lazaris; Stephanie K Petrillo; Jennifer Huxham; Amri Abdellatif; Vincent Palmieri; Jaclyn Chabot; Radia M Johnson; Steven Van Laere; Cornelis Verhoef; Yasmina Hachem; Sara Yumeen; Nicholas Meti; Atilla Omeroglu; Gulbeyaz Altinel; Zu-Hua Gao; Alan S L Yu; Dirk J Grünhagen; Peter Vermeulen; Peter Metrakos; Peter M Siegel
Journal:  Commun Biol       Date:  2021-06-02
  6 in total

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