Literature DB >> 33326106

Ewing Sarcoma PDX Models.

Didier Surdez1, Lorena Landuzzi2, Katia Scotlandi2, Maria Cristina Manara3.   

Abstract

Ewing sarcoma (EWS) is a rare malignant pediatric tumor and patient derived xenografts (PDXs) could represent a possibility to increase the number of available models to study this disease. Compared to cell derived xenografts (CDX), PDXs are reported to better recapitulate tumor microenvironment, heterogeneity, genetic and epigenetic features and are considered reliable models for their better predictive value when comparing preclinical efficacy and treatment response in patients. In this chapter, we extensively describe a method for generating Ewing sarcoma PDX models, for their validation and molecular characterization.

Entities:  

Keywords:  Ewing sarcoma; Immunodeficient mice; Patient-derived xenografts; Pediatric tumors; Preclinical models

Mesh：

Year:  2021        PMID： 33326106     DOI： 10.1007/978-1-0716-1020-6_18

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  18 in total

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Authors:  M F Sanmamed; C Chester; I Melero; H Kohrt
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2.  Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine.

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Journal:  Cancer Discov       Date:  2017-03-22       Impact factor: 39.397

3.  A pilot clinical study of treatment guided by personalized tumorgrafts in patients with advanced cancer.

Authors:  Manuel Hidalgo; Elizabeth Bruckheimer; N V Rajeshkumar; Ignacio Garrido-Laguna; Elizabeth De Oliveira; Belen Rubio-Viqueira; Steven Strawn; Michael J Wick; James Martell; David Sidransky
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4.  Tumorigenesis induced by coexpression of human hepatocyte growth factor and the human met protooncogene leads to high levels of expression of the ligand and receptor.

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Journal:  Cell Growth Differ       Date:  1993-07

5.  Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors.

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Journal:  Ann Oncol       Date:  2017-10-01       Impact factor: 32.976

Review 6.  Patient-derived xenograft models: an emerging platform for translational cancer research.

Authors:  Manuel Hidalgo; Frederic Amant; Andrew V Biankin; Eva Budinská; Annette T Byrne; Carlos Caldas; Robert B Clarke; Steven de Jong; Jos Jonkers; Gunhild Mari Mælandsmo; Sergio Roman-Roman; Joan Seoane; Livio Trusolino; Alberto Villanueva
Journal:  Cancer Discov       Date:  2014-07-15       Impact factor: 39.397

7.  Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials.

Authors:  J I Johnson; S Decker; D Zaharevitz; L V Rubinstein; J M Venditti; S Schepartz; S Kalyandrug; M Christian; S Arbuck; M Hollingshead; E A Sausville
Journal:  Br J Cancer       Date:  2001-05-18       Impact factor: 7.640

8.  A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.

Authors:  Alejandra Bruna; Oscar M Rueda; Wendy Greenwood; Ankita Sati Batra; Maurizio Callari; Rajbir Nath Batra; Katherine Pogrebniak; Jose Sandoval; John W Cassidy; Ana Tufegdzic-Vidakovic; Stephen-John Sammut; Linda Jones; Elena Provenzano; Richard Baird; Peter Eirew; James Hadfield; Matthew Eldridge; Anne McLaren-Douglas; Andrew Barthorpe; Howard Lightfoot; Mark J O'Connor; Joe Gray; Javier Cortes; Jose Baselga; Elisabetta Marangoni; Alana L Welm; Samuel Aparicio; Violeta Serra; Mathew J Garnett; Carlos Caldas
Journal:  Cell       Date:  2016-09-15       Impact factor: 41.582

9.  Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations.

Authors:  Patrizia Nanni; Lorena Landuzzi; Maria Cristina Manara; Alberto Righi; Giordano Nicoletti; Camilla Cristalli; Michela Pasello; Alessandro Parra; Marianna Carrabotta; Manuela Ferracin; Arianna Palladini; Marianna L Ianzano; Veronica Giusti; Francesca Ruzzi; Mauro Magnani; Davide Maria Donati; Piero Picci; Pier-Luigi Lollini; Katia Scotlandi
Journal:  Sci Rep       Date:  2019-08-21       Impact factor: 4.379

10.  Orthotopic patient-derived xenografts of paediatric solid tumours.

Authors:  Elizabeth Stewart; Sara M Federico; Xiang Chen; Anang A Shelat; Cori Bradley; Brittney Gordon; Asa Karlstrom; Nathaniel R Twarog; Michael R Clay; Armita Bahrami; Burgess B Freeman; Beisi Xu; Xin Zhou; Jianrong Wu; Victoria Honnell; Monica Ocarz; Kaley Blankenship; Jason Dapper; Elaine R Mardis; Richard K Wilson; James Downing; Jinghui Zhang; John Easton; Alberto Pappo; Michael A Dyer
Journal:  Nature       Date:  2017-08-30       Impact factor: 49.962
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  2 in total

1.  Establishment and Characterisation of Metastatic Extraskeletal Ewing Sarcoma Mouse Models.

Authors:  Carmelo Cerra; Michael A Harris; Christine J Hawkins
Journal:  In Vivo       Date:  2021 Nov-Dec       Impact factor: 2.155

2.  miR-214-3p Is Commonly Downregulated by EWS-FLI1 and by CD99 and Its Restoration Limits Ewing Sarcoma Aggressiveness.

Authors:  Alessandra De Feo; Laura Pazzaglia; Lisa Ciuffarin; Fabio Mangiagli; Michela Pasello; Elisa Simonetti; Evelin Pellegrini; Cristina Ferrari; Giuseppe Bianchi; Benedetta Spazzoli; Katia Scotlandi
Journal:  Cancers (Basel)       Date:  2022-03-30       Impact factor: 6.639
  2 in total

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