Literature DB >> 33325819

Optogenetics: The Art of Illuminating Complex Signaling Pathways.

Mark Shaaya1, Jordan Fauser1, Andrei V Karginov1,2.   

Abstract

Dissection of cell signaling requires tools that can mimic spatiotemporal dynamics of individual pathways in living cells. Optogenetic methods enable manipulation of signaling processes with precise timing and local control. In this review, we describe recent optogenetic approaches for regulation of cell signaling, highlight their advantages and limitations, and discuss examples of their application.

Entities:  

Keywords:  optogenetics; signaling

Mesh：

Year:  2021        PMID： 33325819      PMCID： PMC8425415          DOI： 10.1152/physiol.00022.2020

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  79 in total

1.  Oligomerization domain-directed reassembly of active dihydrofolate reductase from rationally designed fragments.

Authors:  J N Pelletier; F X Campbell-Valois; S W Michnick
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-13       Impact factor: 11.205

2.  Engineering extrinsic disorder to control protein activity in living cells.

Authors:  Onur Dagliyan; Miroslaw Tarnawski; Pei-Hsuan Chu; David Shirvanyants; Ilme Schlichting; Nikolay V Dokholyan; Klaus M Hahn
Journal:  Science       Date:  2016-12-16       Impact factor: 47.728

3.  Spatio-temporally precise activation of engineered receptor tyrosine kinases by light.

Authors:  Michael Grusch; Karin Schelch; Robert Riedler; Eva Reichhart; Christopher Differ; Walter Berger; Álvaro Inglés-Prieto; Harald Janovjak
Journal:  EMBO J       Date:  2014-07-01       Impact factor: 11.598

4.  Beta-galactosidase. In vivo -complementation.

Authors:  M Villarejo; P J Zamenhof; I Zabin
Journal:  J Biol Chem       Date:  1972-04-10       Impact factor: 5.157

5.  Light-activated protein interaction with high spatial subcellular confinement.

Authors:  Lorena Benedetti; Andrew E S Barentine; Mirko Messa; Heather Wheeler; Joerg Bewersdorf; Pietro De Camilli
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-20       Impact factor: 11.205

6.  Engineering proteins for allosteric control by light or ligands.

Authors:  Onur Dagliyan; Nikolay V Dokholyan; Klaus M Hahn
Journal:  Nat Protoc       Date:  2019-05-10       Impact factor: 13.491

7.  Optogenetic control of phosphoinositide metabolism.

Authors:  Olof Idevall-Hagren; Eamonn J Dickson; Bertil Hille; Derek K Toomre; Pietro De Camilli
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-30       Impact factor: 11.205

8.  Structural details of light activation of the LOV2-based photoswitch PA-Rac1.

Authors:  Andreas Winkler; Thomas R M Barends; Anikó Udvarhelyi; Daniel Lenherr-Frey; Lukas Lomb; Andreas Menzel; Ilme Schlichting
Journal:  ACS Chem Biol       Date:  2014-11-17       Impact factor: 5.100

9.  Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway.

Authors:  L J Bugaj; A J Sabnis; A Mitchell; J E Garbarino; J E Toettcher; T G Bivona; W A Lim
Journal:  Science       Date:  2018-08-31       Impact factor: 47.728

10.  Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells.

Authors:  Dominik Niopek; Dirk Benzinger; Julia Roensch; Thomas Draebing; Pierre Wehler; Roland Eils; Barbara Di Ventura
Journal:  Nat Commun       Date:  2014-07-14       Impact factor: 14.919
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  2 in total

1.  Optical Control of Phosphoinositide Binding: Rapid Activation of Subcellular Protein Translocation and Cell Signaling.

Authors:  Amy Ryan; Gerald R V Hammond; Alexander Deiters
Journal:  ACS Synth Biol       Date:  2021-11-08       Impact factor: 5.249

2.  Restoring circadian gene profiles in clock networks using synthetic feedback control.

Authors:  Mathias Foo; Ozgur E Akman; Declan G Bates
Journal:  NPJ Syst Biol Appl       Date:  2022-02-15
  2 in total

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