Gianpaolo Antonio Basile1, Alessia Bramanti2, Salvatore Bertino1, Giuseppina Cutroneo1, Antonio Bruno3, Adriana Tisano4, Giuseppe Paladina2, Demetrio Milardi1,2, Giuseppe Anastasi1. 1. Brain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Images, University of Messina, 98124 Messina, Italy. 2. IRCCS Centro Neurolesi "Bonino Pulejo", 98124 Messina, Italy. 3. Psychiatry Unit, Department of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, 98124 Messina, Italy. 4. Physical, Rehabilitation Medicine and Sport Medicine Unit, University Hospital G. Martino, 98124 Messina, Italy.
Abstract
Background and objectives: Functional deregulation of dopaminergic midbrain regions is a core feature of schizophrenia pathophysiology. Anatomical research on primates suggests that these regions may be subdivided into distinct, topographically organized functional territories according to their connectivity to the striatum. The aim of the present work was the reconstruction of dopaminergic midbrain subregions in healthy subjects and schizophrenic patients and the evaluation of their structural connectivity profiles. Materials and Methods: A hypothesis-driven connectivity-based parcellation derived from diffusion tractography was applied on 24 healthy subjects and 30 schizophrenic patients to identify distinct territories within the human dopaminergic midbrain in vivo and non-invasively. Results: We identified a tripartite subdivision of dopaminergic midbrain, including limbic, prefrontal and sensorimotor territories. No significant differences in structural features or connectivity were found between subjects and patients. Conclusions: The parcellation scheme proposed herein may help to achieve detailed characterization of structural and functional anomalies of the dopaminergic midbrain in schizophrenic patients.
Background and objectives: Functional deregulation of dopaminergic midbrain regions is a core feature of schizophrenia pathophysiology. Anatomical research on primates suggests that these regions may be subdivided into distinct, topographically organized functional territories according to their connectivity to the striatum. The aim of the present work was the reconstruction of dopaminergic midbrain subregions in healthy subjects and schizophrenicpatients and the evaluation of their structural connectivity profiles. Materials and Methods: A hypothesis-driven connectivity-based parcellation derived from diffusion tractography was applied on 24 healthy subjects and 30 schizophrenicpatients to identify distinct territories within the human dopaminergic midbrain in vivo and non-invasively. Results: We identified a tripartite subdivision of dopaminergic midbrain, including limbic, prefrontal and sensorimotor territories. No significant differences in structural features or connectivity were found between subjects and patients. Conclusions: The parcellation scheme proposed herein may help to achieve detailed characterization of structural and functional anomalies of the dopaminergic midbrain in schizophrenicpatients.
Authors: Bogdan Draganski; Ferath Kherif; Stefan Klöppel; Philip A Cook; Daniel C Alexander; Geoff J M Parker; Ralf Deichmann; John Ashburner; Richard S J Frackowiak Journal: J Neurosci Date: 2008-07-09 Impact factor: 6.167
Authors: Julia Schulz; Juliana Zimmermann; Christian Sorg; Aurore Menegaux; Felix Brandl Journal: Front Psychiatry Date: 2022-09-20 Impact factor: 5.435