BACKGROUND: The signs and symptoms of Zika virus infection are usually mild and self-limited. However, the disease has been linked to neurological complications such as Guillain-Barré syndrome and peripheral nerve involvement, and also to abortion and fetal deaths due to vertical transmission, resulting in various congenital malformations in newborns, including microcephaly. This review aimed to describe the o signs and symptoms that characterize the congenital Zika syndrome. METHODS AND FINDINGS: A systematic review was performed with a protocol and described according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The search strategy yielded 2,048 studies. After the exclusion of duplicates and application of inclusion criteria, 46 studies were included. The main signs and symptoms associated with the congenital Zika syndrome were microcephaly, parenchymal or cerebellar calcifications, ventriculomegaly, central nervous system hypoplasia or atrophy, arthrogryposis, ocular findings in the posterior and anterior segments, abnormal visual function and low birthweight for gestational age. CONCLUSIONS: Zika virus infection during pregnancy can cause a series of changes in the growth and development of children, while impacting the healthcare system due to the severity of cases. Our findings outline the disease profile in newborns and infants and may contribute to the development and updating of more specific clinical protocols.
BACKGROUND: The signs and symptoms of Zika virus infection are usually mild and self-limited. However, the disease has been linked to neurological complications such as Guillain-Barré syndrome and peripheral nerve involvement, and also to abortion and fetal deaths due to vertical transmission, resulting in various congenital malformations in newborns, including microcephaly. This review aimed to describe the o signs and symptoms that characterize the congenital Zika syndrome. METHODS AND FINDINGS: A systematic review was performed with a protocol and described according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The search strategy yielded 2,048 studies. After the exclusion of duplicates and application of inclusion criteria, 46 studies were included. The main signs and symptoms associated with the congenital Zika syndrome were microcephaly, parenchymal or cerebellar calcifications, ventriculomegaly, central nervous system hypoplasia or atrophy, arthrogryposis, ocular findings in the posterior and anterior segments, abnormal visual function and low birthweight for gestational age. CONCLUSIONS:Zika virus infection during pregnancy can cause a series of changes in the growth and development of children, while impacting the healthcare system due to the severity of cases. Our findings outline the disease profile in newborns and infants and may contribute to the development and updating of more specific clinical protocols.
Authors: Laura Riva; Sarah Goellner; Scott B Biering; Chun-Teng Huang; Andrey N Rubanov; Uta Haselmann; Colin M Warnes; Paul D De Jesus; Laura Martin-Sancho; Alexey V Terskikh; Eva Harris; Anthony B Pinkerton; Ralf Bartenschlager; Sumit K Chanda Journal: J Virol Date: 2021-09-01 Impact factor: 5.103
Authors: Elena Marbán-Castro; Cristina Enguita-Fernàndez; Kelly Carolina Romero-Acosta; Germán J Arrieta; Anna Marín-Cos; Salim Mattar; Clara Menéndez; Maria Maixenchs; Azucena Bardají Journal: PLoS Negl Trop Dis Date: 2022-04-18
Authors: Carlos Henrique Fernandes; Rodrigo Guerra Sabongi; João Baptista Gomes Dos Santos Journal: Acta Ortop Bras Date: 2022-01-28 Impact factor: 0.513
Authors: Eunsik Bang; Sujin Oh; Ho Eun Chang; Il Seob Shin; Kyoung Un Park; Eu Suk Kim Journal: Front Cell Infect Microbiol Date: 2022-03-07 Impact factor: 5.293