Wayne Silverman1, Sharon J Krinsky-McHale2,3, Florence Lai4, H Diana Rosas4, Christy Hom2, Eric Doran1, Margaret Pulsifer5, Ira Lott1, Nicole Schupf6,7,8. 1. Department of Pediatrics, University of California, Irvine, Irvine, CA, USA. 2. New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY, USA. 3. Department of Psychiatry, University of California, Irvine, Irvine, CA, USA. 4. Department of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA, USA. 5. Department of Psychiatry, Massachusetts General Hospital, Harvard University, Boston, MA, USA. 6. Sergievsky Center, Taub Institute, New York, CA, USA. 7. Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, CA, USA. 8. Department of Epidemiology, School of Public Health, Columbia University, New York, CA, USA.
Abstract
BACKGROUND: The accuracy of the National Task Group-Early Detection Screen for Dementia (NTG-EDSD) was evaluated in a sample of 185 adults with Down syndrome (DS), emphasizing 'mild cognitive impairment (MCI-DS)'. METHOD: Knowledgeable informants were interviewed with the NTG-EDSD, and findings were compared to an independent dementia status rating based on consensus review of detailed assessments of cognition, functional abilities and health status (including physician examination). RESULTS: Results indicated that sections of the NTG-EDSD were sensitive to MCI-DS, with one or more concerns within the 'Memory' or 'Language and Communication' domains being most informative. CONCLUSIONS: The NTG-EDSD is a useful tool for evaluating dementia status, including MCI-DS. However, estimates of sensitivity and specificity, even for detecting frank dementia, indicated that NTG-EDSD findings need to be supplemented by additional sources of relevant information to achieve an acceptable level of diagnostic/screening accuracy.
BACKGROUND: The accuracy of the National Task Group-Early Detection Screen for Dementia (NTG-EDSD) was evaluated in a sample of 185 adults with Down syndrome (DS), emphasizing 'mild cognitive impairment (MCI-DS)'. METHOD: Knowledgeable informants were interviewed with the NTG-EDSD, and findings were compared to an independent dementia status rating based on consensus review of detailed assessments of cognition, functional abilities and health status (including physician examination). RESULTS: Results indicated that sections of the NTG-EDSD were sensitive to MCI-DS, with one or more concerns within the 'Memory' or 'Language and Communication' domains being most informative. CONCLUSIONS: The NTG-EDSD is a useful tool for evaluating dementia status, including MCI-DS. However, estimates of sensitivity and specificity, even for detecting frank dementia, indicated that NTG-EDSD findings need to be supplemented by additional sources of relevant information to achieve an acceptable level of diagnostic/screening accuracy.
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