Literature DB >> 33314219

mTOR inhibition in COVID-19: A commentary and review of efficacy in RNA viruses.

Basil S Karam1, Rachel S Morris1, Carolyn T Bramante2, Michael Puskarich3, Emily J Zolfaghari4, Sahar Lotfi-Emran5, Nicholas E Ingraham6, Anthony Charles7,8, David J Odde9, Christopher J Tignanelli10,11.   

Abstract

In this commentary, we shed light on the role of the mammalian target of rapamycin (mTOR) pathway in viral infections. The mTOR pathway has been demonstrated to be modulated in numerous RNA viruses. Frequently, inhibiting mTOR results in suppression of virus growth and replication. Recent evidence points towards modulation of mTOR in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We discuss the current literature on mTOR in SARS-CoV-2 and highlight evidence in support of a role for mTOR inhibitors in the treatment of coronavirus disease 2019.
© 2020 Wiley Periodicals LLC.

Entities:  

Keywords:  COVID-19; mTOR; mTORi

Mesh：

Substances：

Year:  2020        PMID： 33314219     DOI： 10.1002/jmv.26728

Source DB:  PubMed          Journal:  J Med Virol        ISSN： 0146-6615            Impact factor:   2.327


  16 in total

1.  Cap-independent translation and a precisely located RNA sequence enable SARS-CoV-2 to control host translation and escape anti-viral response.

Authors:  Boris Slobodin; Urmila Sehrawat; Anastasia Lev; Daniel Hayat; Binyamin Zuckerman; Davide Fraticelli; Ariel Ogran; Amir Ben-Shmuel; Elad Bar-David; Haim Levy; Igor Ulitsky; Rivka Dikstein
Journal:  Nucleic Acids Res       Date:  2022-08-12       Impact factor: 19.160

2.  Association of Antineoplastic Therapy With Decreased SARS-CoV-2 Infection Rates in Patients With Cancer.

Authors:  Michael B Foote; James Robert White; Justin Jee; Guillem Argilés; Jonathan C M Wan; Benoit Rousseau; Melissa S Pessin; Luis A Diaz
Journal:  JAMA Oncol       Date:  2021-11-01       Impact factor: 33.006

3.  mTOR Inhibitor Use Is Associated With a Favorable Outcome of COVID-19 in Patients of Kidney Transplant: Results of a Retrospective Study.

Authors:  Biagio Pinchera; Lorenzo Spirito; Antonio Riccardo Buonomo; Maria Foggia; Rosa Carrano; Fabrizio Salemi; Elisa Schettino; Fortuna Papa; Roberto La Rocca; Felice Crocetto; Luigi Napolitano; Riccardo Villari; Ivan Gentile
Journal:  Front Med (Lausanne)       Date:  2022-06-21

4.  COVID-19 in hospitalized lung and non-lung solid organ transplant recipients: A comparative analysis from a multicenter study.

Authors:  Madeleine R Heldman; Olivia S Kates; Kassem Safa; Camille N Kotton; Sarah J Georgia; Julie M Steinbrink; Barbara D Alexander; Marion Hemmersbach-Miller; Emily A Blumberg; Maria M Crespo; Ashrit Multani; Angelica V Lewis; Omer Eugene Beaird; Brandy Haydel; Ricardo M La Hoz; Lisset Moni; Yesabeli Condor; Sandra Flores; Carlos G Munoz; Juan Guitierrez; Esther I Diaz; Daniela Diaz; Rodrigo Vianna; Giselle Guerra; Matthias Loebe; Robert M Rakita; Maricar Malinis; Marwan M Azar; Vagish Hemmige; Margaret E McCort; Zohra S Chaudhry; Pooja Singh; Kailey Hughes; Arzu Velioglu; Julie M Yabu; Jose A Morillis; Sapna A Mehta; Sajal D Tanna; Michael G Ison; Rade Tomic; Ariella Candace Derenge; David van Duin; Adrienne Maximin; Carlene Gilbert; Jason D Goldman; Sameep Sehgal; Dana Weisshaar; Reda E Girgis; Joanna Nelson; Erika D Lease; Ajit P Limaye; Cynthia E Fisher
Journal:  Am J Transplant       Date:  2021-07-24       Impact factor: 9.369

5.  Outpatient metformin use is associated with reduced severity of COVID-19 disease in adults with overweight or obesity.

Authors:  Carolyn T Bramante; John Buse; Leonardo Tamaritz; Ana Palacio; Ken Cohen; Deneen Vojta; David Liebovitz; Nia Mitchell; Jacinda Nicklas; Ildiko Lingvay; Jeanne M Clark; Louis J Aronne; Erik Anderson; Michael Usher; Ryan Demmer; Genevieve B Melton; Nicholas Ingraham; Christopher J Tignanelli
Journal:  J Med Virol       Date:  2021-03-23       Impact factor: 20.693

Review 6.  Diabetes and COVID-19: The potential role of mTOR.

Authors:  B Pinchera; R Scotto; A R Buonomo; E Zappulo; F Stagnaro; A Gallicchio; G Viceconte; A Sardanelli; S Mercinelli; R Villari; M Foggia; I Gentile
Journal:  Diabetes Res Clin Pract       Date:  2022-03-03       Impact factor: 8.180

7.  PI3K/AKT/mTOR Signaling Pathway Is Required for JCPyV Infection in Primary Astrocytes.

Authors:  Michael P Wilczek; Francesca J Armstrong; Colleen L Mayberry; Benjamin L King; Melissa S Maginnis
Journal:  Cells       Date:  2021-11-18       Impact factor: 6.600

8.  mTOR: A possible therapeutic target against SARS-CoV-2 infection.

Authors:  Nabab Khan
Journal:  Arch Stem Cell Ther       Date:  2021

9.  The Petasites hybridus CO2 Extract (Ze 339) Blocks SARS-CoV-2 Replication In Vitro.

Authors:  Lorena Urda; Matthias Heinrich Kreuter; Jürgen Drewe; Georg Boonen; Veronika Butterweck; Thomas Klimkait
Journal:  Viruses       Date:  2022-01-07       Impact factor: 5.048

Review 10.  Metformin and Covid-19: Focused Review of Mechanisms and Current Literature Suggesting Benefit.

Authors:  Sherehan Ibrahim; Jamie R Lowe; Carolyn T Bramante; Surbhi Shah; Nichole R Klatt; Nancy Sherwood; Louis Aronne; Michael Puskarich; Leonardo Tamariz; Ana Palacio; Eric Bomberg; Michael Usher; Samantha King; Brad Benson; Deneen Vojta; Chris Tignanelli; Nicholas Ingraham
Journal:  Front Endocrinol (Lausanne)       Date:  2021-07-22       Impact factor: 5.555
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