| Literature DB >> 34008917 |
Madeleine R Heldman1, Olivia S Kates1, Kassem Safa2, Camille N Kotton3, Sarah J Georgia2, Julie M Steinbrink4, Barbara D Alexander4, Marion Hemmersbach-Miller5, Emily A Blumberg6, Maria M Crespo7, Ashrit Multani8, Angelica V Lewis8, Omer Eugene Beaird8, Brandy Haydel9, Ricardo M La Hoz10, Lisset Moni11, Yesabeli Condor11, Sandra Flores11, Carlos G Munoz11, Juan Guitierrez11, Esther I Diaz11, Daniela Diaz11, Rodrigo Vianna11, Giselle Guerra11, Matthias Loebe11, Robert M Rakita1, Maricar Malinis12, Marwan M Azar12, Vagish Hemmige13, Margaret E McCort13, Zohra S Chaudhry14, Pooja Singh15, Kailey Hughes16, Arzu Velioglu17, Julie M Yabu18, Jose A Morillis19, Sapna A Mehta20, Sajal D Tanna21, Michael G Ison21, Rade Tomic22, Ariella Candace Derenge23, David van Duin24, Adrienne Maximin25, Carlene Gilbert26, Jason D Goldman1,27, Sameep Sehgal28, Dana Weisshaar29, Reda E Girgis30, Joanna Nelson31, Erika D Lease32, Ajit P Limaye1, Cynthia E Fisher1.
Abstract
Lung transplant recipients (LTR) with coronavirus disease 2019 (COVID-19) may have higher mortality than non-lung solid organ transplant recipients (SOTR), but direct comparisons are limited. Risk factors for mortality specifically in LTR have not been explored. We performed a multicenter cohort study of adult SOTR with COVID-19 to compare mortality by 28 days between hospitalized LTR and non-lung SOTR. Multivariable logistic regression models were used to assess comorbidity-adjusted mortality among LTR vs. non-lung SOTR and to determine risk factors for death in LTR. Of 1,616 SOTR with COVID-19, 1,081 (66%) were hospitalized including 120/159 (75%) LTR and 961/1457 (66%) non-lung SOTR (p = .02). Mortality was higher among LTR compared to non-lung SOTR (24% vs. 16%, respectively, p = .032), and lung transplant was independently associated with death after adjusting for age and comorbidities (aOR 1.7, 95% CI 1.0-2.6, p = .04). Among LTR, chronic lung allograft dysfunction (aOR 3.3, 95% CI 1.0-11.3, p = .05) was the only independent risk factor for mortality and age >65 years, heart failure and obesity were not independently associated with death. Among SOTR hospitalized for COVID-19, LTR had higher mortality than non-lung SOTR. In LTR, chronic allograft dysfunction was independently associated with mortality.Entities:
Keywords: clinical research/practice; infection and infectious agents - viral; infectious disease; lung (allograft) function/dysfunction; lung disease: infectious; lung transplantation/pulmonology; organ transplantation in general
Mesh：
Year: 2021 PMID： 34008917 PMCID： PMC9215359 DOI： 10.1111/ajt.16692
Source DB: PubMed Journal: Am J Transplant ISSN： 1600-6135 Impact factor: 9.369