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Literature DB >> 33309326

Jekyll and Hyde: Activating the Hypoxic Translational Machinery.

J J David Ho¹, Jonathan H Schatz¹, Jim Uniacke², Stephen Lee³.

Abstract

Global translational remodeling has emerged as a principal mechanism of biological adaptation. Oxygen deficiency (hypoxia) disables the basal protein synthesis machinery ('Jekyll') and activates a hypoxic translational architecture ('Hyde') to drive translatome remodeling. Independent from mRNA-level fluctuations, this newer paradigm modernizes a field traditionally dominated by the hypoxia-inducible factor (HIF) transcriptional program. Crown

Entities: Chemical

Keywords: HIF; hypoxia; oxygen; protein synthesis; translation heterogeneity; translatome

Mesh：

Substances：

Year: 2020 PMID： 33309326 PMCID： PMC8720417 DOI： 10.1016/j.tibs.2020.11.006

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

15 in total

1. Eukaryotic mRNPs may represent posttranscriptional operons.

Authors: Jack D Keene; Scott A Tenenbaum
Journal: Mol Cell Date: 2002-06 Impact factor: 17.970

Review 2. On the Dependency of Cellular Protein Levels on mRNA Abundance.

Authors: Yansheng Liu; Andreas Beyer; Ruedi Aebersold
Journal: Cell Date: 2016-04-21 Impact factor: 41.582

3. Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus.

Authors: J J David Ho; Miling Wang; Timothy E Audas; Deukwoo Kwon; Steven K Carlsson; Sara Timpano; Sonia L Evagelou; Shaun Brothers; Mark L Gonzalgo; Jonathan R Krieger; Steven Chen; James Uniacke; Stephen Lee
Journal: Cell Rep Date: 2016-02-04 Impact factor: 9.423

Review 4. Heterogeneity and specialized functions of translation machinery: from genes to organisms.

Authors: Naomi R Genuth; Maria Barna
Journal: Nat Rev Genet Date: 2018-07 Impact factor: 53.242

Review 5. A Cap for Every Occasion: Alternative eIF4F Complexes.

Authors: J J David Ho; Stephen Lee
Journal: Trends Biochem Sci Date: 2016-06-06 Impact factor: 13.807

6. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Authors: G L Wang; B H Jiang; E A Rue; G L Semenza
Journal: Proc Natl Acad Sci U S A Date: 1995-06-06 Impact factor: 11.205

7. An oxygen-regulated switch in the protein synthesis machinery.

Authors: James Uniacke; Chet E Holterman; Gabriel Lachance; Aleksandra Franovic; Mathieu D Jacob; Marc R Fabian; Josianne Payette; Martin Holcik; Arnim Pause; Stephen Lee
Journal: Nature Date: 2012-05-06 Impact factor: 49.962

8. Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B.

Authors: J J David Ho; Nathan C Balukoff; Grissel Cervantes; Petrice D Malcolm; Jonathan R Krieger; Stephen Lee
Journal: Cell Rep Date: 2018-01-02 Impact factor: 9.423

9. A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism.

Authors: J J David Ho; Nathan C Balukoff; Phaedra R Theodoridis; Miling Wang; Jonathan R Krieger; Jonathan H Schatz; Stephen Lee
Journal: Nat Commun Date: 2020-05-29 Impact factor: 14.919

10. Hypoxia influences polysome distribution of human ribosomal protein S12 and alternative splicing of ribosomal protein mRNAs.

Authors: Andrea Brumwell; Leslie Fell; Lindsay Obress; James Uniacke
Journal: RNA Date: 2020-01-07 Impact factor: 4.942

2 in total

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Authors: Peter M Abuja; Kurt Zatloukal; Helmut Denk
Journal: Int J Mol Sci Date: 2021-11-21 Impact factor: 5.923

2. Quantitative Analyses Reveal How Hypoxia Reconfigures the Proteome of Primary Cytotoxic T Lymphocytes.

Authors: Sarah H Ross; Christina M Rollings; Doreen A Cantrell
Journal: Front Immunol Date: 2021-09-17 Impact factor: 7.561

2 in total