Miguel A Sanchez-Lastra1, Ding Ding2, Knut-Eirik Dalene3, Ulf Ekelund4, Jakob Tarp5. 1. Department of Special Didactics, Faculty of Educational Sciences and Sports, University of Vigo, Pontevedra, Spain. 2. Prevention Research Collaboration, Sydney School of Public Health, The University of Sydney, Camperdown, NSW Australia. 3. Department of Sports Medicine, Norwegian School of Sports Sciences, Oslo, Norway. 4. Department of Sports Medicine, Norwegian School of Sports Sciences, Oslo, Norway; Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway. 5. Department of Sports Medicine, Norwegian School of Sports Sciences, Oslo, Norway. Electronic address: jakob.tarp@nih.no.
Abstract
OBJECTIVE: To examine the combined and stratified associations of physical activity and adiposity measures, modelled as body mass index (BMI), abdominal adiposity (waist circumference), and body fat percentage (BF) with all-cause mortality. PATIENTS AND METHODS: Using the UK Biobank cohort, we extracted quintiles of self-reported weekly physical activity. Categories of measured BMI, waist circumference, and BF were generated. Joint associations between physical activity-adiposity categories and mortality were examined using Cox proportional hazards models adjusted for demographic, behavioral, and clinical covariates. Physical activity-mortality associations were also examined within adiposity strata. Participants were followed from baseline (2006 to 2010) through January 31, 2018. RESULTS: A total of 295,917 participants (median follow-up, 8.9 years, during which 6684 deaths occurred) were included. High physical activity was associated with lower risk of premature mortality in all strata of adiposity except for those with BMI ≥35 kg/m2. Highest risk (HR, 1.54; 95% CI; 1.33 to 1.79) was observed in individuals with low physical activity and high BF as compared with the high physical activity-low BF referent. High physical activity attenuated the risk of high adiposity when using BF (HR, 1.24; 95% CI; 1.04 to 1.49), but the association was weaker with BMI (HR, 1.45; 95% CI; 1.21 to 1.73). Physical activity also attenuated the association between mortality and high waist circumference. CONCLUSION: Low physical activity and adiposity were both associated with a higher risk of premature mortality, but high physical activity attenuated the increased risk with adiposity irrespective of adiposity metric, except in those with a BMI ≥35 kg/m2.
OBJECTIVE: To examine the combined and stratified associations of physical activity and adiposity measures, modelled as body mass index (BMI), abdominal adiposity (waist circumference), and body fat percentage (BF) with all-cause mortality. PATIENTS AND METHODS: Using the UK Biobank cohort, we extracted quintiles of self-reported weekly physical activity. Categories of measured BMI, waist circumference, and BF were generated. Joint associations between physical activity-adiposity categories and mortality were examined using Cox proportional hazards models adjusted for demographic, behavioral, and clinical covariates. Physical activity-mortality associations were also examined within adiposity strata. Participants were followed from baseline (2006 to 2010) through January 31, 2018. RESULTS: A total of 295,917 participants (median follow-up, 8.9 years, during which 6684 deaths occurred) were included. High physical activity was associated with lower risk of premature mortality in all strata of adiposity except for those with BMI ≥35 kg/m2. Highest risk (HR, 1.54; 95% CI; 1.33 to 1.79) was observed in individuals with low physical activity and high BF as compared with the high physical activity-low BF referent. High physical activity attenuated the risk of high adiposity when using BF (HR, 1.24; 95% CI; 1.04 to 1.49), but the association was weaker with BMI (HR, 1.45; 95% CI; 1.21 to 1.73). Physical activity also attenuated the association between mortality and high waist circumference. CONCLUSION: Low physical activity and adiposity were both associated with a higher risk of premature mortality, but high physical activity attenuated the increased risk with adiposity irrespective of adiposity metric, except in those with a BMI ≥35 kg/m2.
Authors: Elin Ekblom-Bak; Mats Börjesson; Frida Bergman; Göran Bergström; Albin Dahlin-Almevall; Isabel Drake; Gunnar Engström; Jan E Engvall; Anders Gummesson; Emil Hagström; Ola Hjelmgren; Tomas Jernberg; Peter J Johansson; Lars Lind; Maria Mannila; André Nyberg; Margaretha Persson; Christian Reitan; Annika Rosengren; Karin Rådholm; Caroline Schmidt; Magnus C Sköld; Emily Sonestedt; Johan Sundström; Eva Swahn; Jerry Öhlin; Carl Johan Östgren; Örjan Ekblom Journal: Scand J Med Sci Sports Date: 2022-02-07 Impact factor: 4.645
Authors: Po Wen Ku; Emmanuel Stamatakis; Matthew N Ahmadi; I-Min Lee; Mark Hamer; Borja Del Pozo Cruz; Li Jung Chen; Elif Eroglu; Yun-Ju Lai Journal: Int J Obes (Lond) Date: 2022-08-01 Impact factor: 5.551
Authors: Jakob Tarp; Morten W Fagerland; Knut Eirik Dalene; Jostein Steene Johannessen; Bjørge H Hansen; Barbara J Jefferis; Peter H Whincup; Keith M Diaz; Steven Hooker; Virginia J Howard; Ariel Chernofsky; Martin G Larson; Nicole L Spartano; Ramachandran S Vasan; Ing-Mari Dohrn; Maria Hagströmer; Charlotte Edwardson; Thomas Yates; Eric J Shiroma; Paddy C Dempsey; Katrien Wijndaele; Sigmund A Anderssen; I-Min Lee; Ulf Ekelund Journal: Br J Sports Med Date: 2021-12-07 Impact factor: 18.473