N Broman1, K Rantasärkkä2, T Feuth3, M Valtonen4, M Waris2, U Hohenthal5, E Rintala6, A Karlsson7, H Marttila6, V Peltola8, T Vuorinen2, J Oksi5. 1. Department of Infectious Diseases, Turku University Hospital, Turku, Finland. 2. Department of Clinical Microbiology, Turku University Hospital and Institute of Biomedicine, University of Turku, Turku, Finland. 3. Department of Pulmonary Diseases, Turku University Hospital and Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland. 4. Department of Anaesthesia and Intensive Care, Turku University Hospital, Turku, Finland. 5. Department of Infectious Diseases, Turku University Hospital and University of Turku, Turku, Finland. 6. Department of Hospital Hygiene and Infection Control, Turku University Hospital, Turku, Finland. 7. Auria Biobank, Turku University Hospital and University of Turku, Turku, Finland. 8. Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Abstract
OBJECTIVE: Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers. METHODS: We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order to identify markers of severe COVID-19 and need of ICU. RESULTS: Patients who were eventually admitted to ICU displayed significantly higher serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin. No statistical differences were found between the groups in median levels of lymphocytes, D-dimer or ferritin. CONCLUSIONS: IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19.
OBJECTIVE: Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers. METHODS: We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order to identify markers of severe COVID-19 and need of ICU. RESULTS:Patients who were eventually admitted to ICU displayed significantly higher serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin. No statistical differences were found between the groups in median levels of lymphocytes, D-dimer or ferritin. CONCLUSIONS:IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19.
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