| Literature DB >> 33303463 |
Tianyin Liu1, Shiyu Lu1, Dara K Y Leung1, Lesley C Y Sze1, Wai Wai Kwok1, Jennifer Y M Tang1, Hao Luo1, Terry Y S Lum1, Gloria H Y Wong2.
Abstract
OBJECTIVE: Loneliness is a significant and independent risk factor for depression in later life. Particularly in Asian culture, older people may find it less stigmatising to express loneliness than depression. This study aimed to adapt a simple loneliness screen for use in older Chinese, and to ascertain its relevance in detecting depressive symptoms as a community screening tool. DESIGN, SETTING AND PARTICIPANTS: This cross-sectional study was conducted among 1653 older adults aged 60 years or above living in the community in Hong Kong. This was a convenient sample recruited from four local non-governmental organisations providing community eldercare or mental healthcare services. All data was collected by trained social workers through face-to-face interviews. MEASURES: Loneliness was measured using an adapted Chinese version of UCLA 3-item Loneliness Scale, depression symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), and social support with emotional and instrumental support proxies (number of people who can offer help). Basic demographics including age, gender, education and living arrangement were also recorded.Entities:
Keywords: depression & mood disorders; geriatric medicine; mental health; old age psychiatry; preventive medicine; public health
Mesh:
Year: 2020 PMID: 33303463 PMCID: PMC7733209 DOI: 10.1136/bmjopen-2020-041921
Source DB: PubMed Journal: BMJ Open ISSN: 2044-6055 Impact factor: 2.692
Characteristics of the study participants (n=1653)
| Demographics | Category | N (%) | Mean (SD) |
| Age, years | – | 77.98 (8.24) | |
| Gender | Female | 1289 (78) | – |
| Male | 364 (22) | – | |
| Work, years | – | 30.99 (14.78) | |
| Education, level (missing, n=21) | No formal education (including bok bok zaai*) | 575 (34.8) | – |
| Primary education | 613 (37.1) | – | |
| Secondary education | 376 (22.8) | – | |
| Higher education (associate degree or above) | 68 (4.1) | – | |
| Education, years | – | 4.86 (4.40) | |
| Living arrangement | Alone | 742 (44.9) | – |
| Otherwise | 911 (55.1) | – | |
| Emotional support | 0 person | 569 (34.4) | – |
| 1 person | 765 (46.3) | – | |
| 2 persons | 217 (13.1) | – | |
| 3 persons | 66 (4) | – | |
| 4 persons | 23 (1.4) | – | |
| 5 persons | 13 (0.8) | – | |
| Total number | – | 0.94 (0.94) | |
| Instrumental support | 0 person | 457 (27.7) | – |
| 1 person | 911 (55.1) | – | |
| 2 persons | 194 (11.7) | – | |
| 3 persons | 58 (3.5) | – | |
| 4 persons | 21 (1.3) | – | |
| 5 persons | 12 (0.7) | – | |
| Total number | – | 0.98 (0.87) | |
| MoCA 5-min | Possible score range (0 to 30); actual score range (9.5 to 30) | 21.05 (4.57) | |
| PHQ-9 | Possible score range (0 to 27); actual score range (0 to 23) | – | 6.62 (4.13) |
| 0 to 4 No depression | 468 (28.3) | ||
| 5 to 9 Mild depressive symptoms | 874 (52.9) | ||
| 10 to 14 Moderate depressive symptoms | 239 (14.5) | ||
| ≥15 Moderately severe and more serious | 72 (4.4) | ||
| UCLA 3-item | Possible score range (0 to 9); actual score range (0 to 9) | – | 3.91 (3.02) |
*bok bok zaai: 1 to 3 years’ informal education provided by private institutions in Cantonese speaking regions, gradually disappearing since the New Culture Movement in China in the 1910s.
MoCA 5-min, Montreal Cognitive Assessment 5-minute protocol; PHQ-9, Patient Health Questionnaire-9.
Correlations between UCLA 3-item loneliness scale and selected variables
| Variable | Coefficients | P value |
| 1. Scale item 1: lack companionship (0 to 3) | 0.90* | <0.001 |
| 2. Scale item 2: feel left out (0 to 3) | 0.88* | <0.001 |
| 3. Scale item 3: feel isolated from others (0 to 3) | 0.89* | <0.001 |
| 4. PHQ-9 score (0 to 27) | 0.42* | <0.001 |
| 5. Emotional support (0 to 5) (No. of people to talk to when feeling down) | −0.13† | <0.001 |
| 6. Instrumental support (0 to 5) (No. of people to help with everyday tasks) | −0.09† | <0.001 |
| 7. Living arrangement (0 to 1) (Living with someone versus living alone) | 0.17† | <0.001 |
| 8. Age | −0.05* | <0.001 |
*Pearson’s correlation coefficients show individual item correlations with the 3-item loneliness scale.
†Spearman’s correlation coefficients show the associations between the 3-item loneliness scale and related variables.
PHQ-9, Patient Health Questionnaire-9.
Regression models on PHQ-9 scores with different predictors
| Variable | Model 1 | Model 2 | Model 3 | ||||||
| B | SE(B) | β | B | SE(B) | β | B | SE(B) | β | |
| Constant | 10.44*** | 1.00 | 9.96*** | 1.01 | 6.27*** | 0.93 | |||
| Age (range: 60 to 106 years) | −0.05** | 0.01 | −0.11** | −0.05** | 0.01 | −0.10** | −0.03* | 0.01 | −0.05* |
| Female (ref: male) | 0.30 | 0.24 | 0.03 | 0.22 | 0.25 | 0.02 | 0.13 | 0.22 | 0.01 |
| Living alone (0 to 1) | −0.36 | 0.21 | −0.04 | −0.30 | 0.21 | −0.04 | −0.91*** | 0.19 | −0.11*** |
| Emotional support (0 to 5) | 0.34* | 0.15 | 0.08* | 0.55*** | 0.14 | 0.12*** | |||
| Instrumental support (0 to 5) | −0.07 | 0.16 | −0.02 | −0.07 | 0.15 | −0.02 | |||
| UCLA 3-item score (0 to 9) | 0.59*** | 0.03 | 0.43*** | ||||||
| R2 | 0.01** | 0.02* | 0.19*** | ||||||
| F(df) | 7.95 (3 to 1649) | 6.26 (5 to 1647) | 67.44 (6 to 1646) | ||||||
| Δ R2 | 0.01** | 0.004* | 0.18** | ||||||
***p<.000; **p<0.01; *p<0.05.
PHQ-9, Patient Health Questionnaire-9.
Sensitivity, specificity, AUC, PPV, NPV with 95% CI for each optional cut-off based on Youden’s criterion
| No depression versus | |||
| ≥mild depressive symptoms | ≥moderate depressive symptoms | ≥moderately severe depressive symptoms | |
| Cut-off | ≥3 | ≥4 | ≥4 |
| Sensitivity (95% CI) | 76.4 (73.8 to 78.8) | 68.8 (63.3 to 73.9) | 81.9 (71.1 to 90.0) |
| Specificity (95% CI) | 62.2 (57.6 to 66.6) | 54.7 (52.0 to 57.4) | 51.7 (49.2 to 54.2) |
| PPV (95% CI) | 83.6 (80.9 to 85.4) | 26.0 (24.0 to 31.1) | 7.2 (6.5 to 13.3) |
| NPV (95% CI) | 51.0 (47.6 to 55.8) | 88.3 (85.6 to 89.4) | 98.4 (97.2 to 98.6) |
| J | 0.39 | 0.24 | 0.34 |
| AUC (95% CI) | 0.73 (0.70 to 0.75) | 0.66 (0.62 to 0.69) | 0.73 (0.67 to 0.79) |
| SE | 0.01 | 0.02 | 0.03 |
| z | 17.17*** | 9.01*** | 7.45** |
***p<0.000; **p<0.01.
AUC, area under the curve; J, Youden’s index; NPV, negative predictive value; PPV, positive predictive value.;
Figure 1Receiver operating characteristic curve of the UCLA 3-item loneliness scale for the detection of (A) mild and more serious depressive symptoms (PHQ-9 ≥5), (B) moderate and more serious depressive symptoms (PHQ-9 ≥10), and (C) moderately severe and more serious depressive symptoms (PHQ-9 ≥15). PHQ-9, Patient Health Questionnaire-9.