| Literature DB >> 33301826 |
Anne Lotz1, Beate Pesch2, Swaantje Casjens3, Martin Lehnert4, Wolfgang Zschiesche5, Dirk Taeger6, Chien-Lin Yeh7, Tobias Weiss8, Tobias Schmidt-Wilcke9, Clara Quetscher10, Stefan Gabriel11, Maria Angela Samis Zella12, Dirk Woitalla13, Ulrike Dydak14, Christoph van Thriel15, Thomas Brüning16, Thomas Behrens17.
Abstract
The aim of this study was to evaluate the effect of exposure to manganese (Mn) on fine motor functions. A total of 48 welders and 30 unexposed workers as controls completed questionnaires, underwent blood examinations, and a motor test battery. The shift exposure of welders to respirable Mn was measured with personal samplers. For all subjects accumulations of Mn in the brain were assessed with T1-weighted magnetic resonance imaging. Welders showed normal motor functions on the Movement Disorder Society-Sponsored Revision of the Unified Parkinson Disease Rating Scale part III. Furthermore welders performed excellent on a steadiness test, showing better results than controls. However, welders were slightly slower than controls in motor tests. There was no association between fine motor test results and the relaxation rates R1 in globus pallidus and substantia nigra as MRI-based biomarkers to quantify Mn deposition in the brain.Entities:
Keywords: Globus pallidus; MRI; Metals; Neurobehaviour; Neurotoxicity; Substantia nigra
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Year: 2020 PMID： 33301826 PMCID： PMC8793460 DOI： 10.1016/j.neuro.2020.12.003
Source DB: PubMed Journal: Neurotoxicology ISSN： 0161-813X Impact factor: 4.398