Peter D Fransquet1, Paul Lacaze1, Richard Saffery2, James Phung1, Emily Parker1, Raj C Shah3, Anne Murray4, Robyn L Woods1, Joanne Ryan1,5. 1. School of Public Health & Preventive Medicine, Monash University, Melbourne, 3004 Victoria, Australia. 2. Murdoch Children's Research Institute & Department of Paediatrics, The University of Melbourne, Parkville, 3052 Victoria, Australia. 3. Department of Family Medicine & Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. 4. Berman Center for Outcomes & Clinical Research, Hennepin Healthcare Research Institute, Hennepin Healthcare; Division of Geriatrics, Department of Medicine, University of Minnesota, Minneapolis, MN, USA. 5. PSNREC, University of Montpellier, INSERM, Montpellier, France.
Abstract
Aim: To investigate whether genes implicated in dementia pathogenesis are differently methylated in peripheral blood. Materials & methods: Participants included 160 cognitively healthy individuals aged 70+ years: 73 who were subsequently diagnosed with dementia and 87 controls matched on age, gender, education, smoking and baseline cognition. A total of 49 participants also provided blood samples at diagnosis. Blood DNA methylation of APOE, APP, BDNF, PIN1, SNCA and TOMM40 was examined. Results: A total of 56 of 299 probes were differentially methylated in dementia compared with controls and 39 probes prior to diagnosis. The greatest effect size was in APP (cg19423170, Δ-8.32%, adjusted p = 0.009 at diagnosis; cg19933173, Δ-4.18%, adjusted p < 0.0001 prediagnosis). Conclusion: Genes implicated in dementia pathogenesis show differential blood methylation in dementia, even prior to diagnosis.
Aim: To investigate whether genes implicated in dementia pathogenesis are differently methylated in peripheral blood. Materials & methods: Participants included 160 cognitively healthy individuals aged 70+ years: 73 who were subsequently diagnosed with dementia and 87 controls matched on age, gender, education, smoking and baseline cognition. A total of 49 participants also provided blood samples at diagnosis. Blood DNA methylation of APOE, APP, BDNF, PIN1, SNCA and TOMM40 was examined. Results: A total of 56 of 299 probes were differentially methylated in dementia compared with controls and 39 probes prior to diagnosis. The greatest effect size was in APP (cg19423170, Δ-8.32%, adjusted p = 0.009 at diagnosis; cg19933173, Δ-4.18%, adjusted p < 0.0001 prediagnosis). Conclusion: Genes implicated in dementia pathogenesis show differential blood methylation in dementia, even prior to diagnosis.
Authors: B Arosio; A Bulbarelli; S Bastias Candia; E Lonati; L Mastronardi; P Romualdi; S Candeletti; C Gussago; D Galimberti; E Scarpini; B Dell'Osso; C Altamura; M MacCarrone; L Bergamaschini; C D'Addario; D Mari Journal: Neurodegener Dis Date: 2012-01-17 Impact factor: 2.977
Authors: Joanne Ryan; Robyn L Woods; Carlene Britt; Anne M Murray; Raj C Shah; Christopher M Reid; Brenda Kirpach; Rory S Wolfe; Mark R Nelson; Jessica E Lockery; Suzanne G Orchard; Ruth E Trevaks; John J McNeil; Elsdon Storey Journal: Clin Neuropsychol Date: 2018-07-05 Impact factor: 3.535
Authors: Joanne Ryan; Robyn L Woods; Anne M Murray; Raj C Shah; Carlene J Britt; Christopher M Reid; Rory Wolfe; Mark R Nelson; Jessica E Lockery; Suzanne G Orchard; Ruth E Trevaks; Trevor J Chong; John J McNeil; Elsdon Storey Journal: Clin Neuropsychol Date: 2020-02-26 Impact factor: 4.373
Authors: Jiaxuan Liu; Wei Zhao; Erin B Ware; Stephen T Turner; Thomas H Mosley; Jennifer A Smith Journal: BMC Med Genomics Date: 2018-05-08 Impact factor: 3.063
Authors: Lucas A Salas; Devin C Koestler; Rondi A Butler; Helen M Hansen; John K Wiencke; Karl T Kelsey; Brock C Christensen Journal: Genome Biol Date: 2018-05-29 Impact factor: 13.583
Authors: Tiago C Silva; Juan I Young; Lanyu Zhang; Lissette Gomez; Michael A Schmidt; Achintya Varma; X Steven Chen; Eden R Martin; Lily Wang Journal: Nat Commun Date: 2022-08-18 Impact factor: 17.694
Authors: Tiago C Silva; Wei Zhang; Juan I Young; Lissette Gomez; Michael A Schmidt; Achintya Varma; X Steven Chen; Eden R Martin; Lily Wang Journal: Alzheimers Res Ther Date: 2022-09-15 Impact factor: 8.823
Authors: Amery Treble-Barna; Lacey W Heinsberg; Ava M Puccio; John R Shaffer; David O Okonkwo; Sue R Beers; Daniel E Weeks; Yvette P Conley Journal: Neurorehabil Neural Repair Date: 2021-06-25 Impact factor: 3.919