Christopher Lotz1, Ralf M Muellenbach2, Patrick Meybohm1, Haitham Mutlak3, Philipp M Lepper4, Caroline-Barbara Rolfes2, Asghar Peivandi5, Jan Stumpner1, Markus Kredel1, Peter Kranke1, Iuliu Torje2, Christian Reyher2. 1. Department of Anaesthesiology and Critical Care Medicine, University of Würzburg, Würzburg, Germany. 2. Department of Critical Care, Emergency Medicine and Anaesthesiology, ARDS/ECMO-Center, University of Southampton, Kassel, Germany. 3. Department of Anaesthesiology, Intensive Care and Emergency Medicine, Sana Klinikum Offenbach, Kassel, Germany. 4. Department of Internal Medicine V-Pulmonology, Allergology and Critical Care Medicine, Saarland University, Homburg, Germany. 5. Department of Cardiovascular Surgery, ARDS/ECMO-Center, University of Southampton, Kassel, Germany.
Abstract
BACKGROUND: Changes in pulmonary hemodynamics and ventilation/perfusion were proposed as hallmarks of Coronavirus disease 2019 (COVID-19)-induced acute respiratory distress syndrome (ARDS). Inhaled nitric oxide (iNO) may overcome these issues and improve arterial oxygenation. METHODS: We retrospectively analyzed arterial oxygenation and pulmonary vasoreactivity in seven COVID-19 ARDS patients receiving 20 ppm iNO for 15-30 minutes. RESULTS: The inhalation of NO significantly improved oxygenation. All patients with severe ARDS had higher partial pressures of oxygen and reduced pulmonary vascular resistance. Significant changes in pulmonary shunting were not observed. CONCLUSION: Overall, iNO could provide immediate help and delay respiratory deterioration in COVID-19-induced moderate to severe ARDS.
BACKGROUND: Changes in pulmonary hemodynamics and ventilation/perfusion were proposed as hallmarks of Coronavirus disease 2019 (COVID-19)-induced acute respiratory distress syndrome (ARDS). Inhaled nitric oxide (iNO) may overcome these issues and improve arterial oxygenation. METHODS: We retrospectively analyzed arterial oxygenation and pulmonary vasoreactivity in seven COVID-19ARDSpatients receiving 20 ppm iNO for 15-30 minutes. RESULTS: The inhalation of NO significantly improved oxygenation. All patients with severe ARDS had higher partial pressures of oxygen and reduced pulmonary vascular resistance. Significant changes in pulmonary shunting were not observed. CONCLUSION: Overall, iNO could provide immediate help and delay respiratory deterioration in COVID-19-induced moderate to severe ARDS.
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