Literature DB >> 35138438

Investigational antiviral drugs for the treatment of COVID-19 patients.

Samineh Beheshtirouy1, Elnaz Khani1, Sajad Khiali1, Taher Entezari-Maleki2,3.   

Abstract

In the current pandemic of coronavirus disease 2019 (COVID-19), antiviral drugs are at the center of attention because of their critical role against severe acute respiratory disease syndrome coronavirus 2 (SARS-CoV-2). In addition to designing new antivirals against SARS-COV-2, a drug repurposing strategy is a practical approach for treating COVID-19. A brief insight about antivirals would help clinicians to choose the best medication for the treatment of COVID-19. In this review, we discuss both novel and repurposed investigational antivirals, focusing on in vitro, in vivo, and clinical trial studies.
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

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Year:  2022        PMID: 35138438     DOI: 10.1007/s00705-022-05368-z

Source DB:  PubMed          Journal:  Arch Virol        ISSN: 0304-8608            Impact factor:   2.574


  88 in total

1.  Phase I clinical and pharmacokinetic trial of Brequinar sodium (DuP 785; NSC 368390).

Authors:  C L Arteaga; T D Brown; J G Kuhn; H S Shen; T J O'Rourke; K Beougher; H J Brentzel; D D Von Hoff; G R Weiss
Journal:  Cancer Res       Date:  1989-08-15       Impact factor: 12.701

Review 2.  Arbidol: a broad-spectrum antiviral compound that blocks viral fusion.

Authors:  Y S Boriskin; I A Leneva; E-I Pécheur; S J Polyak
Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530

3.  Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and S.

Authors:  Sara Akerström; Ali Mirazimi; Yee-Joo Tan
Journal:  Antiviral Res       Date:  2006-11-07       Impact factor: 5.970

Review 4.  COVID-19: pathogenesis, advances in treatment and vaccine development and environmental impact-an updated review.

Authors:  Youssef A Attia; Mohamed T El-Saadony; Ayman A Swelum; Shaza Y A Qattan; Adel D Al-Qurashi; Khalid A Asiry; Manal E Shafi; Ahmed R Elbestawy; Ahmed R Gado; Asmaa F Khafaga; Elsayed O S Hussein; Hani Ba-Awadh; Ruchi Tiwari; Kuldeep Dhama; Bakr Alhussaini; Salem R Alyileili; Khaled A El-Tarabily; Mohamed E Abd El-Hack
Journal:  Environ Sci Pollut Res Int       Date:  2021-03-18       Impact factor: 4.223

5.  Brilacidin Demonstrates Inhibition of SARS-CoV-2 in Cell Culture.

Authors:  Allison Bakovic; Kenneth Risner; Nishank Bhalla; Farhang Alem; Theresa L Chang; Warren K Weston; Jane A Harness; Aarthi Narayanan
Journal:  Viruses       Date:  2021-02-09       Impact factor: 5.048

6.  ADAMTSL5 is an epigenetically activated gene underlying tumorigenesis and drug resistance in hepatocellular carcinoma.

Authors:  Maria Arechederra; Sehrish K Bazai; Ahmed Abdouni; Celia Sequera; Timothy J Mead; Sylvie Richelme; Fabrice Daian; Stéphane Audebert; Rosanna Dono; Anthony Lozano; Damien Gregoire; Urszula Hibner; Daniela S Allende; Suneel S Apte; Flavio Maina
Journal:  J Hepatol       Date:  2020-11-13       Impact factor: 25.083

Review 7.  Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia.

Authors:  W Barcellini; B Fattizzo
Journal:  Dis Markers       Date:  2015-12-27       Impact factor: 3.434

8.  Dual effect of nitric oxide on SARS-CoV replication: viral RNA production and palmitoylation of the S protein are affected.

Authors:  Sara Akerström; Vithiagaran Gunalan; Choong Tat Keng; Yee-Joo Tan; Ali Mirazimi
Journal:  Virology       Date:  2009-10-01       Impact factor: 3.616

9.  Mitigation of the replication of SARS-CoV-2 by nitric oxide in vitro.

Authors:  Dario Akaberi; Janina Krambrich; Jiaxin Ling; Chen Luni; Göran Hedenstierna; Josef D Järhult; Johan Lennerstrand; Åke Lundkvist
Journal:  Redox Biol       Date:  2020-09-21       Impact factor: 11.799

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  1 in total

1.  Smart therapies against global pandemics: A potential of short peptides.

Authors:  Vasso Apostolopoulos; Joanna Bojarska; Jack Feehan; John Matsoukas; Wojciech Wolf
Journal:  Front Pharmacol       Date:  2022-08-15       Impact factor: 5.988

  1 in total

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