Qi Lin1, Fei-Ying Zhu1, Yong-Qiang Shu2, Pei-Wen Zhu1, Lei Ye1, Wen-Qing Shi1, You-Lan Min1, Biao Li1, Qing Yuan1, Yi Shao1. 1. Department of Ophthalmology, Jiangxi Province Ocular Disease Clinical Research Center, The First Affiliated Hospital of Nanchang University, Nanchang, China. 2. Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Abstract
OBJECTIVE: The purpose of this study is to explore the underlying functional network brain activity changes of patients in middle-aged with retinitis pigmentosa (RP) and the relationships with clinical features such as depression scale and visual functioning using voxel-wise degree centrality (DC) method. METHODS: We included 16 patients with RP (11 men, 5 women) and 16 healthy controls (HCs; 11 men, 5 women). Participants were matched in terms of age, weight, gender and handedness (age and weight between the two groups were compared using independent sample t-tests, gender and handedness were compared using chi-square test). We use the voxel-wise DC method to assess spontaneous brain activity. Receiver operating characteristic (ROC) curve analysis was performed to distinguish between RP patients and HCs. Correlation analysis was used to examine the relationships between mean DC values in various brain regions and clinical features (such as depression scale and visual functioning) in RP patients. RESULTS: Compared with HCs, the DC values of patients with RP were reduced in the right medial frontal gyrus, bilateral cuneus, bilateral precuneus, and bilateral superior frontal gyrus, and increased in the right cerebellum posterior lobe, left inferior temporal gyrus, and right fusiform gyrus. The mean DC values in the bilateral cuneus negatively correlated with the depression scale, and those in the bilateral precuneus positively correlated with the Visual Functioning Questionnaire-25. CONCLUSIONS: Middle-aged patients with RP exhibit abnormal brain network activity in various brain regions, and this may underlie the pathological mechanism of RP.
OBJECTIVE: The purpose of this study is to explore the underlying functional network brain activity changes of patients in middle-aged with retinitis pigmentosa (RP) and the relationships with clinical features such as depression scale and visual functioning using voxel-wise degree centrality (DC) method. METHODS: We included 16 patients with RP (11 men, 5 women) and 16 healthy controls (HCs; 11 men, 5 women). Participants were matched in terms of age, weight, gender and handedness (age and weight between the two groups were compared using independent sample t-tests, gender and handedness were compared using chi-square test). We use the voxel-wise DC method to assess spontaneous brain activity. Receiver operating characteristic (ROC) curve analysis was performed to distinguish between RP patients and HCs. Correlation analysis was used to examine the relationships between mean DC values in various brain regions and clinical features (such as depression scale and visual functioning) in RP patients. RESULTS: Compared with HCs, the DC values of patients with RP were reduced in the right medial frontal gyrus, bilateral cuneus, bilateral precuneus, and bilateral superior frontal gyrus, and increased in the right cerebellum posterior lobe, left inferior temporal gyrus, and right fusiform gyrus. The mean DC values in the bilateral cuneus negatively correlated with the depression scale, and those in the bilateral precuneus positively correlated with the Visual Functioning Questionnaire-25. CONCLUSIONS: Middle-aged patients with RP exhibit abnormal brain network activity in various brain regions, and this may underlie the pathological mechanism of RP.
Authors: Jie Yang; Mengru Zhang; Hongshik Ahn; Qing Zhang; Tony B Jin; Ien Li; Matthew Nemesure; Nandita Joshi; Haoran Jiang; Jeffrey M Miller; Robert Todd Ogden; Eva Petkova; Matthew S Milak; Mary Elizabeth Sublette; Gregory M Sullivan; Madhukar H Trivedi; Myrna Weissman; Patrick J McGrath; Maurizio Fava; Benji T Kurian; Diego A Pizzagalli; Crystal M Cooper; Melvin McInnis; Maria A Oquendo; Joseph John Mann; Ramin V Parsey; Christine DeLorenzo Journal: Hum Brain Mapp Date: 2018-08-16 Impact factor: 5.038
Authors: Gang Tan; Zeng-Renqing Dan; Ying Zhang; Xin Huang; Yu-Lin Zhong; Lin-Hong Ye; Rong Rong; Lei Ye; Qiong Zhou; Yi Shao Journal: J Int Med Res Date: 2017-07-06 Impact factor: 1.671