Literature DB >> 3329047

Induction of yeast DNA ligase genes in exponential and stationary phase cultures in response to DNA damaging agents.

A L Johnson1, D G Barker, L H Johnston.   

Abstract

UV-irradiation of stationary phase cells of Saccharomyces cerevisiae and Schizosaccharomyces pombe leads to a 9-fold and 90-fold increase in transcript levels from the respective DNA ligase genes CDC9 and CDC17, whereas exponential cells show only 3-fold and 2-fold increases. Induction of CDC9 after MMS treatment and gamma-irradiation was also observed by using a CDC9-lacZ translational fusion and assaying for beta-galactosidase. Surprisingly, irradiation of S. cerevisiae induces only a 50% increase in DNA ligase itself, probably reflecting the extremely high in vivo stability of the enzyme. The UV-induction of ligase may be part of a "fail-safe" mechanism which, together with the enzyme stability, ensures adequate supplies of this essential enzyme.

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Year:  1986        PMID： 3329047     DOI： 10.1007/bf00378201

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  22 in total

1.  Regulation of CDC9, the Saccharomyces cerevisiae gene that encodes DNA ligase.

Authors:  T A Peterson; L Prakash; S Prakash; M A Osley; S I Reed
Journal:  Mol Cell Biol       Date:  1985-01       Impact factor: 4.272

Review 2.  Inducibility of error-prone DNA repair in yeast?

Authors:  W Siede; F Eckardt
Journal:  Mutat Res       Date:  1984-10       Impact factor: 2.433

3.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

4.  Beta-galactosidase gene fusions for analyzing gene expression in escherichia coli and yeast.

Authors:  M J Casadaban; A Martinez-Arias; S K Shapira; J Chou
Journal:  Methods Enzymol       Date:  1983       Impact factor: 1.600

5.  Cloning and characterization of the Schizosaccharomyces pombe DNA ligase gene CDC17.

Authors:  L H Johnston; D G Barker; P Nurse
Journal:  Gene       Date:  1986       Impact factor: 3.688

6.  Ligase-deficient yeast cells exhibit defective DNA rejoining and enhanced gamma ray sensitivity.

Authors:  C W Moore
Journal:  J Bacteriol       Date:  1982-06       Impact factor: 3.490

7.  The DNA repair capability of cdc9, the Saccharomyces cerevisiae mutant defective in DNA ligase.

Authors:  L H Johnston
Journal:  Mol Gen Genet       Date:  1979-02-16

8.  An improved assay for DNA ligase reveals temperature-sensitive activity in cdc9 mutants of Saccharomyces cerevisiae.

Authors:  D G Barker; A L Johnson; L H Johnston
Journal:  Mol Gen Genet       Date:  1985

9.  Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents.

Authors:  S W Ruby; J W Szostak
Journal:  Mol Cell Biol       Date:  1985-01       Impact factor: 4.272

10.  Periodic transcription as a means of regulating gene expression during the cell cycle: contrasting modes of expression of DNA ligase genes in budding and fission yeast.

Authors:  J H White; D G Barker; P Nurse; L H Johnston
Journal:  EMBO J       Date:  1986-07       Impact factor: 11.598
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  19 in total

1.  DNA polymerase delta isolated from Schizosaccharomyces pombe contains five subunits.

Authors:  S Zuo; E Gibbs; Z Kelman; T S Wang; M O'Donnell; S A MacNeill; J Hurwitz
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

Review 2.  Cell cycle control of DNA synthesis in budding yeast.

Authors:  L H Johnston; N F Lowndes
Journal:  Nucleic Acids Res       Date:  1992-05-25       Impact factor: 16.971

3.  The yeast DNA ligase gene CDC9 is controlled by six orientation specific upstream activating sequences that respond to cellular proliferation but which alone cannot mediate cell cycle regulation.

Authors:  J H White; A L Johnson; N F Lowndes; L H Johnston
Journal:  Nucleic Acids Res       Date:  1991-01-25       Impact factor: 16.971

4.  Role of the casein kinase I isoform, Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae.

Authors:  Y Ho; S Mason; R Kobayashi; M Hoekstra; B Andrews
Journal:  Proc Natl Acad Sci U S A       Date:  1997-01-21       Impact factor: 11.205

5.  Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells.

Authors:  A J Fornace; B Zmudzka; M C Hollander; S H Wilson
Journal:  Mol Cell Biol       Date:  1989-02       Impact factor: 4.272

6.  Expression of the yeast PHR1 gene is induced by DNA-damaging agents.

Authors:  J Sebastian; B Kraus; G B Sancar
Journal:  Mol Cell Biol       Date:  1990-09       Impact factor: 4.272

7.  The yeast DNA polymerase I transcript is regulated in both the mitotic cell cycle and in meiosis and is also induced after DNA damage.

Authors:  L H Johnston; J H White; A L Johnson; G Lucchini; P Plevani
Journal:  Nucleic Acids Res       Date:  1987-07-10       Impact factor: 16.971

8.  The DNA repair genes RAD54 and UNG1 are cell cycle regulated in budding yeast but MCB promoter elements have no essential role in the DNA damage response.

Authors:  L H Johnston; A L Johnson
Journal:  Nucleic Acids Res       Date:  1995-06-25       Impact factor: 16.971

9.  Late induction of human DNA ligase I after UV-C irradiation.

Authors:  A Montecucco; E Savini; G Biamonti; M Stefanini; F Focher; G Ciarrocchi
Journal:  Nucleic Acids Res       Date:  1995-03-25       Impact factor: 16.971

10.  DNA ligase I gene expression during differentiation and cell proliferation.

Authors:  A Montecucco; G Biamonti; E Savini; F Focher; S Spadari; G Ciarrocchi
Journal:  Nucleic Acids Res       Date:  1992-12-11       Impact factor: 16.971
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