Hanna Lee1, Carolyn M Slupsky1,2, Anne Heckmann3, Britt Christensen4, Yongmei Peng5, Xiaonan Li6, Olle Hernell7, Bo Lönnerdal2, Zailing Li8. 1. H. Lee, C. M. Slupsky, Department of Food Science and Technology, University of California-Davis, California, CA, USA. 2. C. M. Slupsky, B. Lönnerdal, Department of Nutrition, University of California-Davis, California, CA, USA. 3. A. Heckmann, Arla Foods Ingredients, 8260 Viby J, Aarhus N, Denmark. 4. B. Christensen, Arla Foods amba, Arla Innovation Center, Skejby, Aarhus N, Denmark. 5. Y. Peng, Department of Child Health Care, Children's Hospital, Fudan University, Shanghai, China. 6. X. Li, Department of Child Health Care, Children's Hospital of Nanjing Medical University, Nanjing, China. 7. O. Hernell, Department of Clinical Sciences, Pediatrics, Umeå University, Sweden, Sweden. 8. Z. Li, Department of Pediatrics, Peking University Third Hospital, Beijing, China.
Abstract
SCOPE: Milk fat globule membrane (MFGM) is an important component of milk that has previously been removed in the manufacture of infant formulas, but has recently gained attention owing to its potential to improve immunological, cognitive, and metabolic health. The goal of this study wasto determine whether supplementing MFGM in an infant formula would drive desirable changes in metabolism and gut microbiota to elicit benefits observed in prior studies. METHODS AND RESULTS: The serum metabolome and fecal microbiota wereanalyzed using 1 H NMR spectroscopy and 16S rRNA gene sequencing respectively in a cohort of Chinese infants given a standard formula or a formula supplemented with an MFGM-enriched whey protein fraction. Supplementing MFGM suppressed protein degradation pathways and the levels of insulinogenic amino acids that are typically enhanced in formula-fed infants while facilitating fatty acid oxidation and ketogenesis, a feature that may favor brain development. MFGM supplementation didnot induce significant compositional changes in the fecal microbiota but suppressed microbial diversity and altered microbiota-associated metabolites. CONCLUSION: Supplementing MFGM in a formula reduced some metabolic gaps between formula-fed and breastfed infants. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
SCOPE: Milk fat globule membrane (MFGM) is an important component of milk that has previously been removed in the manufacture of infant formulas, but has recently gained attention owing to its potential to improve immunological, cognitive, and metabolic health. The goal of this study wasto determine whether supplementing MFGM in an infant formula would drive desirable changes in metabolism and gut microbiota to elicit benefits observed in prior studies. METHODS AND RESULTS: The serum metabolome and fecal microbiota wereanalyzed using 1 H NMR spectroscopy and 16S rRNA gene sequencing respectively in a cohort of Chinese infants given a standard formula or a formula supplemented with an MFGM-enriched whey protein fraction. Supplementing MFGM suppressed protein degradation pathways and the levels of insulinogenic amino acids that are typically enhanced in formula-fed infants while facilitating fatty acid oxidation and ketogenesis, a feature that may favor brain development. MFGM supplementation didnot induce significant compositional changes in the fecal microbiota but suppressed microbial diversity and altered microbiota-associated metabolites. CONCLUSION: Supplementing MFGM in a formula reduced some metabolic gaps between formula-fed and breastfed infants. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
Authors: Ellen Looijesteijn; Rutger W W Brouwer; Ruud J W Schoemaker; Wilfred F J van IJcken; Yannis Manios; Laurien H Ulfman; Stephanie L Ham; Prescilla Jeurink; Eva Karaglani Journal: BMC Nutr Date: 2022-08-29