Literature DB >> 33280032

Poor sleep correlates with biomarkers of neurodegeneration in mild traumatic brain injury patients: a CENC study.

J Kent Werner1,2, Pashtun Shahim3,2, Josephine U Pucci1, Chen Lai3, Sorana Raiciulescu1, Jessica M Gill3, Risa Nakase-Richardson4,5,6, Ramon Diaz-Arrastia7, Kimbra Kenney1.   

Abstract

STUDY
OBJECTIVES: Sleep disorders affect over half of mild traumatic brain injury (mTBI) patients. Despite evidence linking sleep and neurodegeneration, longitudinal TBI-related dementia studies have not considered sleep. We hypothesized that poor sleepers with mTBI would have elevated markers of neurodegeneration and lower cognitive function compared to mTBI good sleepers and controls. Our objective was to compare biomarkers of neurodegeneration and cognitive function with sleep quality in warfighters with chronic mTBI.
METHODS: In an observational warfighters cohort (n = 138 mTBI, 44 controls), the Pittsburgh Sleep Quality Index (PSQI) was compared with plasma biomarkers of neurodegeneration and cognitive scores collected an average of 8 years after injury.
RESULTS: In the mTBI cohort, poor sleepers (PSQI ≥ 10, n = 86) had elevated plasma neurofilament light (NfL, x̅ = 11.86 vs 7.91 pg/mL, p = 0.0007, d = 0.63) and lower executive function scores by the categorical fluency (x̅ = 18.0 vs 21.0, p = 0.0005, d = -0.65) and stop-go tests (x̅ = 30.1 vs 31.1, p = 0.024, d = -0.37). These findings were not observed in controls (n = 44). PSQI predicted NfL (beta = 0.22, p = 0.00002) and tau (beta = 0.14, p = 0.007), but not amyloid β42. Poor sleepers showed higher obstructive sleep apnea (OSA) risk by STOP-BANG scores (x̅ = 3.8 vs 2.7, p = 0.0005), raising the possibility that the PSQI might be partly secondary to OSA.
CONCLUSIONS: Poor sleep is linked to neurodegeneration and select measures of executive function in mTBI patients. This supports implementation of validated sleep measures in longitudinal studies investigating pathobiological mechanisms of TBI related neurodegeneration, which could have therapeutic implications. © Sleep Research Society 2020. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

Entities:  

Keywords:  amyloid; dementia; military health; neurofilament; sleep disorders; tau; traumatic brain injury

Mesh：

Substances：

Year:  2021        PMID： 33280032      PMCID： PMC8343591          DOI： 10.1093/sleep/zsaa272

Source DB:  PubMed          Journal:  Sleep        ISSN： 0161-8105            Impact factor:   5.849


  55 in total

1.  Symptom validity test performance in U.S. veterans referred for evaluation of mild TBI.

Authors:  Patrick Armistead-Jehle
Journal:  Appl Neuropsychol       Date:  2010-01

2.  Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women.

Authors:  Kristine Yaffe; Alison M Laffan; Stephanie Litwack Harrison; Susan Redline; Adam P Spira; Kristine E Ensrud; Sonia Ancoli-Israel; Katie L Stone
Journal:  JAMA       Date:  2011-08-10       Impact factor: 56.272

3.  Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau-Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers.

Authors:  Richard Rubenstein; Binggong Chang; John K Yue; Allen Chiu; Ethan A Winkler; Ava M Puccio; Ramon Diaz-Arrastia; Esther L Yuh; Pratik Mukherjee; Alex B Valadka; Wayne A Gordon; David O Okonkwo; Peter Davies; Sanjeev Agarwal; Fan Lin; George Sarkis; Hamad Yadikar; Zhihui Yang; Geoffrey T Manley; Kevin K W Wang; Shelly R Cooper; Kristen Dams-O'Connor; Allison J Borrasso; Tomoo Inoue; Andrew I R Maas; David K Menon; David M Schnyer; Mary J Vassar
Journal:  JAMA Neurol       Date:  2017-09-01       Impact factor: 18.302

4.  Verbal learning strategy following mild traumatic brain injury.

Authors:  Elizabeth K Geary; Marilyn F Kraus; Leah H Rubin; Neil H Pliskin; Deborah M Little
Journal:  J Int Neuropsychol Soc       Date:  2011-07       Impact factor: 2.892

5.  The Chronic Effects of Neurotrauma Consortium (CENC) multi-centre observational study: Description of study and characteristics of early participants.

Authors:  W C Walker; W Carne; L M Franke; T Nolen; S D Dikmen; D X Cifu; K Wilson; H G Belanger; R Williams
Journal:  Brain Inj       Date:  2016       Impact factor: 2.311

6.  The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research.

Authors:  D J Buysse; C F Reynolds; T H Monk; S R Berman; D J Kupfer
Journal:  Psychiatry Res       Date:  1989-05       Impact factor: 3.222

Review 7.  The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders.

Authors:  Alessandro Didonna; Puneet Opal
Journal:  Mol Neurodegener       Date:  2019-05-16       Impact factor: 14.195

8.  The association of insomnia and sleep apnea with deployment and combat exposure in the entire population of US army soldiers from 1997 to 2011: a retrospective cohort investigation.

Authors:  John A Caldwell; Joseph J Knapik; Tracie L Shing; Joseph R Kardouni; Harris R Lieberman
Journal:  Sleep       Date:  2019-08-01       Impact factor: 5.849

9.  Repetitive Mild Traumatic Brain Injury Alters Glymphatic Clearance Rates in Limbic Structures of Adolescent Female Rats.

Authors:  Jennaya Christensen; David K Wright; Glenn R Yamakawa; Sandy R Shultz; Richelle Mychasiuk
Journal:  Sci Rep       Date:  2020-04-10       Impact factor: 4.379

10.  Plasma tau in Alzheimer disease.

Authors:  Niklas Mattsson; Henrik Zetterberg; Shorena Janelidze; Philip S Insel; Ulf Andreasson; Erik Stomrud; Sebastian Palmqvist; David Baker; Cristina A Tan Hehir; Andreas Jeromin; David Hanlon; Linan Song; Leslie M Shaw; John Q Trojanowski; Michael W Weiner; Oskar Hansson; Kaj Blennow
Journal:  Neurology       Date:  2016-09-30       Impact factor: 9.910
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  5 in total

Review 1.  The Bidirectional Link Between Sleep Disturbances and Traumatic Brain Injury Symptoms: A Role for Glymphatic Dysfunction?

Authors:  Juan A Piantino; Jeffrey J Iliff; Miranda M Lim
Journal:  Biol Psychiatry       Date:  2021-07-14       Impact factor: 13.382

2.  Trajectories of Insomnia in Adults After Traumatic Brain Injury.

Authors:  Emerson M Wickwire; Jennifer S Albrecht; Vincent F Capaldi; Sonia O Jain; Raquel C Gardner; J Kent Werner; Pratik Mukherjee; Ashlee B McKeon; Michael T Smith; Joseph T Giacino; Lindsay D Nelson; Scott G Williams; Jacob Collen; Xiaoying Sun; David M Schnyer; Amy J Markowitz; Geoffrey T Manley; Andrew D Krystal
Journal:  JAMA Netw Open       Date:  2022-01-04

3.  Poor Sleep Quality is Linked to Elevated Extracellular Vesicle-Associated Inflammatory Cytokines in Warfighters With Chronic Mild Traumatic Brain Injuries.

Authors:  Jackie L Gottshall; Vivian A Guedes; Josephine U Pucci; Daniel Brooks; Nora Watson; Phorum Sheth; Ainslee Gabriel; Sara Mithani; Jacqueline J Leete; Chen Lai; Bao-Xi Qu; Christina Devoto; Jessica M Gill; Kimbra Kenney; J Kent Werner
Journal:  Front Pharmacol       Date:  2022-01-27       Impact factor: 5.810

4.  Extracellular vesicle neurofilament light is elevated within the first 12-months following traumatic brain injury in a U.S military population.

Authors:  Vivian A Guedes; Rael T Lange; Sara M Lippa; Chen Lai; Kisha Greer; Sara Mithani; Christina Devoto; Katie A Edwards; Chelsea L Wagner; Carina A Martin; Angela E Driscoll; Megan M Wright; Kelly C Gillow; Samantha M Baschenis; Tracey A Brickell; Louis M French; Jessica M Gill
Journal:  Sci Rep       Date:  2022-03-07       Impact factor: 4.379

5.  Assessing Cognitive Behavioral Therapy for Insomnia to Improve Sleep Outcomes in Individuals With a Concussion: Protocol for a Delayed Randomized Controlled Trial.

Authors:  Rebecca Ludwig; Michael Rippee; Linda J D'Silva; Jeff Radel; Aaron M Eakman; Jill Morris; Michelle Drerup; Catherine Siengsukon
Journal:  JMIR Res Protoc       Date:  2022-09-23
  5 in total

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