| Literature DB >> 33273063 |
Zhenyu Tian1,2, Haoqi Zhao3, Katherine T Peter1,2, Melissa Gonzalez1,2, Jill Wetzel4, Christopher Wu1,2, Ximin Hu3, Jasmine Prat4, Emma Mudrock4, Rachel Hettinger1,2, Allan E Cortina1,2, Rajshree Ghosh Biswas5, Flávio Vinicius Crizóstomo Kock5, Ronald Soong5, Amy Jenne5, Bowen Du6, Fan Hou3, Huan He3, Rachel Lundeen1,2, Alicia Gilbreath7, Rebecca Sutton7, Nathaniel L Scholz8, Jay W Davis9, Michael C Dodd3, Andre Simpson5, Jenifer K McIntyre4, Edward P Kolodziej10,2,3.
Abstract
In U.S. Pacific Northwest coho salmon (Oncorhynchus kisutch), stormwater exposure annually causes unexplained acute mortality when adult salmon migrate to urban creeks to reproduce. By investigating this phenomenon, we identified a highly toxic quinone transformation product of N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), a globally ubiquitous tire rubber antioxidant. Retrospective analysis of representative roadway runoff and stormwater-affected creeks of the U.S. West Coast indicated widespread occurrence of 6PPD-quinone (<0.3 to 19 micrograms per liter) at toxic concentrations (median lethal concentration of 0.8 ± 0.16 micrograms per liter). These results reveal unanticipated risks of 6PPD antioxidants to an aquatic species and imply toxicological relevance for dissipated tire rubber residues.Entities:
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Year: 2020 PMID： 33273063 DOI： 10.1126/science.abd6951
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728