Literature DB >> 33270480

Need to take special care of non-responders to hepatitis B vaccination among health-care workers, students and chronic patients.

Angela Bechini1, Paolo Bonanni1, Maddalena Grazzini1, Diana Paolini1, Giulio Arcangeli2, Nicola Mucci2, Costanza Bini2, Emilia Tiscione1, Beatrice Zanella1, Sara Boccalini1.   

Abstract

Both our research and that published by Sticchi et al. on immunological memory against hepatitis B virus (HBV) in health-care workers (HCWs) vaccinated as infants or adolescents confirm that in those testing negative after the primary course, one additional (fourth) booster dose is able to elicit an anti-HBs response in >85% subjects. The fifth and the sixth doses further contribute substantially to a high overall response rate. The rate of subjects showing an anamnestic response after the booster dose was almost six-fold higher in HCWs compared to chronic patients. Since universal vaccination in Italy resulted in a significant decrease in HBV infections, special attention and testing should be addressed to those affected by chronic diseases.

Entities:  

Keywords:  Hepatitis B; additional doses; anti-HBs testing; chronic patients; healthcare workers; non-responders; vaccination

Year:  2020        PMID： 33270480      PMCID： PMC7899626          DOI： 10.1080/21645515.2020.1810495

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN： 2164-5515            Impact factor:   3.452


  18 in total

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Authors:  Paolo Bonanni; Giovanna Pesavento; Sara Boccalini; Angela Bechini
Journal:  J Hepatol       Date:  2003       Impact factor: 25.083

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3.  [The 2014 lifetime immunization schedule approved by the Italian scientific societies. Italian Society of Hygiene, Preventive Medicine, and Public Health. Italian Society of Pediatrics. Italian Federation of Pediatric Physicians. Italian Federation of General Medical Physicians. Arezzo Service of Legal Medicine].

Authors:  Paolo Bonanni; Chiara Azzari; Paolo Castiglia; Giampietro Chiamenti; Giorgio Conforti; Michele Conversano; Giovanni Corsello; Giuseppe Ferrera; Antonio Ferro; Giancarlo Icardi; Pasquale Giuseppe Macrì; Tommaso Maio; Walter Ricciardi; Rocco Russo; Silvestro Scotti; Carlo Signorelli; Luigi Sudano; Alberto Giovanni Ugazio; Alberto Villani; Giovanni Vitali Rosati
Journal:  Epidemiol Prev       Date:  2014 Nov-Dec       Impact factor: 1.901

Review 4.  Induced immunity against hepatitis B virus.

Authors:  Zeinab Nabil Ahmed Said; Kouka Saadeldin Abdelwahab
Journal:  World J Hepatol       Date:  2015-06-28

Review 5.  Vaccine safety evaluation: Practical aspects in assessing benefits and risks.

Authors:  Alberta Di Pasquale; Paolo Bonanni; Nathalie Garçon; Lawrence R Stanberry; Mostafa El-Hodhod; Fernanda Tavares Da Silva
Journal:  Vaccine       Date:  2016-11-08       Impact factor: 3.641

6.  Impact of universal vaccination programmes on the epidemiology of hepatitis B: 10 years of experience in Italy.

Authors:  Paolo Bonanni; Giovanna Pesavento; Angela Bechini; Emilia Tiscione; Francesco Mannelli; Cristiana Benucci; Antonella Lo Nostro
Journal:  Vaccine       Date:  2003-01-30       Impact factor: 3.641

7.  Sero-epidemiology of hepatitis B markers in the population of Tuscany, Central Italy, 20 years after the implementation of universal vaccination.

Authors:  Sara Boccalini; Elettra Pellegrino; Emila Tiscione; Giovanna Pesavento; Angela Bechini; Miriam Levi; Stefano Rapi; Stefano Mercurio; Francesco Mannelli; Marta Peruzzi; Cesare Berardi; Paolo Bonanni
Journal:  Hum Vaccin Immunother       Date:  2013-01-25       Impact factor: 3.452

8.  Implementation in Italy of a universal vaccination programme against hepatitis B.

Authors:  P Bonanni
Journal:  Vaccine       Date:  1995       Impact factor: 3.641

9.  Is hepatitis B vaccination performed at infant and adolescent age able to provide long-term immunological memory? An observational study on healthcare students and workers in Florence, Italy.

Authors:  Costanza Bini; Maddalena Grazzini; Martina Chellini; Nicola Mucci; Giulio Arcangeli; Emilia Tiscione; Paolo Bonanni
Journal:  Hum Vaccin Immunother       Date:  2017-12-19       Impact factor: 3.452

10.  High chance to overcome the non-responder status to hepatitis B vaccine after a further full vaccination course: results from the extended study on healthcare students and workers in Florence, Italy.

Authors:  Maddalena Grazzini; Giulio Arcangeli; Nicola Mucci; Paolo Bonanni; Costanza Bini; Angela Bechini; Sara Boccalini; Emilia Tiscione; Diana Paolini
Journal:  Hum Vaccin Immunother       Date:  2019-12-18       Impact factor: 3.452
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