Ai-Ris Y Collier1,2, Rachel Ledyard3, Diana Montoya-Williams3,4, Maylene Qiu5, Alexandra E Dereix3,6, Minou Raschid Farrokhi1,7, Michele R Hacker1,2,8, Heather H Burris3,4. 1. Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. 2. Department of Obstetrics, Gynecology, & Reproductive Biology, Harvard Medical School, Boston, MA 02115, USA. 3. Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. 4. Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. 5. Biomedical Library, University of Pennsylvania, Philadelphia, PA 19104, USA. 6. Loyola University Chicago Stritch School of Medicine, Maywood, IL 60153, USA. 7. Colby College, Waterville, ME 04901, USA. 8. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Abstract
Aim: We conducted a systematic review evaluating race/ethnicity representation in DNA methylomic studies of preterm birth. Data sources: PubMed, EMBASE, CINHAL, Scopus and relevant citations from 1 January 2000 to 30 June 2019. Study appraisal & synthesis methods: Two authors independently identified abstracts comparing DNA methylomic differences between term and preterm births that included race/ethnicity data. Results: 16 studies were included. Black and non-Hispanic Black deliveries were well represented (28%). However, large studies originating from more than 95% White populations were excluded due to unreported race/ethnicity data. Most studies were cross-sectional, allowing for reverse causation. Most studies were also racially/ethnically homogeneous, preventing direct comparison of DNA methylomic differences across race/ethnicities. Conclusion: In DNA methylomic studies, Black women and infants were well represented. However, the literature has limitations and precludes drawing definitive conclusions.
Aim: We conducted a systematic review evaluating race/ethnicity representation in DNA methylomic studies of preterm birth. Data sources: PubMed, EMBASE, CINHAL, Scopus and relevant citations from 1 January 2000 to 30 June 2019. Study appraisal & synthesis methods: Two authors independently identified abstracts comparing DNA methylomic differences between term and preterm births that included race/ethnicity data. Results: 16 studies were included. Black and non-Hispanic Black deliveries were well represented (28%). However, large studies originating from more than 95% White populations were excluded due to unreported race/ethnicity data. Most studies were cross-sectional, allowing for reverse causation. Most studies were also racially/ethnically homogeneous, preventing direct comparison of DNA methylomic differences across race/ethnicities. Conclusion: In DNA methylomic studies, Black women and infants were well represented. However, the literature has limitations and precludes drawing definitive conclusions.
Entities:
Keywords:
DNA methylation; epigenetics; epigenomics; gestational age; health disparities; methylomics; pregnancy; preterm birth; race and ethnicity; systematic review
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