Maria Kyriakidou1,2, Ilias Chatziioannidis2, Georgios Mitsiakos2, Sofia Lampropoulou3, Abraham Pouliakis4. 1. Occupational Therapy Department, University of Western Macedonia, 50100 Kozani, Greece. 2. 2nd Neonatology Department, Aristotle University, 56403 Thessaloniki, Greece. 3. Physiotherapy Department, School of Health Rehabilitation Sciences, University of Patras, 25100 Aigio, Greece. 4. 2nd Department of Pathology, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Abstract
Background and objectives: The aims of this study were to examine the relationship between neurological outcomes at 3- and 6-months corrected age with the neurodevelopmental outcome at 3 years of age; to identify the perinatal/neonatal risk factors for poor neurodevelopmental outcomes at 3 years of age. Materials and methods: In our single-centre longitudinal cohort study, of the 73 consecutive infants admitted to our Neonatal Intensive Care Unit (NICU), 49 infants (80%) received both Hammersmith Infant Neurological Examination (HINE) at 3- and 6-months corrected age and Bayley-III neurodevelopmental assessment at 2-3 years chronological age. At 3 months follow up, 8.2% had suboptimal scores (below 10th percentile) on the HINE. At 6 months follow up, 4.1% had suboptimal scores (below 10th percentile) on the HINE. The means(±SD) for Bayley-III cognitive, language, and motor subscales were (96.3 ± 9.8), (99.9 ± 11.9), (93.2 ± 9.9). Results: At 3 months corrected age, higher total HINE scores and subscores for function of cranial nerves, posture, tone, were associated with better cognitive scores while poorer scores for function of cranial nerves, posture, movements, tone, and total HINE score were associated with lower motor scores. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have three times higher odds of having a motor delay. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have more than two times higher odds of having a language delay. At 6 months corrected age, poorer scores for function of cranial nerves, movements, tone, reflexes, and total HINE score were associated with worse Bayley-III motor scores whilst infants who have a total HINE score and a subscore of reflexes in the suboptimal range have four and seven times, respectively, higher odds of having a motor delay. Conclusions: Early identification of infants at risk for adverse long-term outcomes is essential in introducing early intervention therapies for optimizing neurodevelopmental outcomes.
Background and objectives: The aims of this study were to examine the relationship between neurological outcomes at 3- and 6-months corrected age with the neurodevelopmental outcome at 3 years of age; to identify the perinatal/neonatal risk factors for poor neurodevelopmental outcomes at 3 years of age. Materials and methods: In our single-centre longitudinal cohort study, of the 73 consecutive infants admitted to our Neonatal Intensive Care Unit (NICU), 49 infants (80%) received both Hammersmith Infant Neurological Examination (HINE) at 3- and 6-months corrected age and Bayley-III neurodevelopmental assessment at 2-3 years chronological age. At 3 months follow up, 8.2% had suboptimal scores (below 10th percentile) on the HINE. At 6 months follow up, 4.1% had suboptimal scores (below 10th percentile) on the HINE. The means(±SD) for Bayley-III cognitive, language, and motor subscales were (96.3 ± 9.8), (99.9 ± 11.9), (93.2 ± 9.9). Results: At 3 months corrected age, higher total HINE scores and subscores for function of cranial nerves, posture, tone, were associated with better cognitive scores while poorer scores for function of cranial nerves, posture, movements, tone, and total HINE score were associated with lower motor scores. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have three times higher odds of having a motor delay. Infants with a HINE subscore of function of cranial nerves in the suboptimal range have more than two times higher odds of having a language delay. At 6 months corrected age, poorer scores for function of cranial nerves, movements, tone, reflexes, and total HINE score were associated with worse Bayley-III motor scores whilst infants who have a total HINE score and a subscore of reflexes in the suboptimal range have four and seven times, respectively, higher odds of having a motor delay. Conclusions: Early identification of infants at risk for adverse long-term outcomes is essential in introducing early intervention therapies for optimizing neurodevelopmental outcomes.
Authors: Betty R Vohr; Bonnie E Stephens; Rosemary D Higgins; Carla M Bann; Susan R Hintz; Abhik Das; Jamie E Newman; Myriam Peralta-Carcelen; Kimberly Yolton; Anna M Dusick; Patricia W Evans; Ricki F Goldstein; Richard A Ehrenkranz; Athina Pappas; Ira Adams-Chapman; Deanne E Wilson-Costello; Charles R Bauer; Anna Bodnar; Roy J Heyne; Yvonne E Vaucher; Robert G Dillard; Michael J Acarregui; Elisabeth C McGowan; Gary J Myers; Janell Fuller Journal: J Pediatr Date: 2012-03-14 Impact factor: 4.406
Authors: Domenico M M Romeo; Matteo Cioni; Mariacristina Scoto; Alessandra Pizzardi; Mario G Romeo; Andrea Guzzetta Journal: Early Hum Dev Date: 2009-02-20 Impact factor: 2.079
Authors: Alicia J Spittle; Megan M Spencer-Smith; Abbey L Eeles; Katherine J Lee; Lucy E Lorefice; Peter J Anderson; Lex W Doyle Journal: Dev Med Child Neurol Date: 2012-12-06 Impact factor: 5.449
Authors: Daniela Dicanio; Giulia Spoto; Angela Alibrandi; Roberta Minutoli; Antonio Gennaro Nicotera; Gabriella Di Rosa Journal: Front Neurol Date: 2022-09-27 Impact factor: 4.086