BACKGROUND: Longitudinal motor assessment in infants at different neurodevelopmental risk has not been previously evaluated using structured assessments. AIM: To verify if the Hammersmith Infant Neurological Examination (HINE) is a good tool to predict the neuromotor outcome in infants discharged from a level II-III Neonatal Intensive Care Unit (NICU) METHODS: In this cohort analysis, 1541 infants discharged from our NICU between January of 2002 and the April 2006 were enrolled and assessed using the HINE at 3, 6, 9, 12 months. At two years, these infants were further assessed, and grouped into infants with normal outcome (1150), with mild disability (321) and with cerebral palsy (70), RESULTS: Correlation analysis of Spearman showed a significant (p < 0.0001) and moderate (r(2) = -0.55 to -0.73) negative correlation between HINE scores (3, 6, 9, 12 months) and neurological outcome at two years. Cut-off scores for each assessment' age were provided as predictive value for cerebral palsy. DISCUSSION: This study mainly showed that HINE, as soon as the first months of life, helps in the process of prediction of neurological outcome at two years of age in a heterogeneous population of infants discharged from an NICU.
BACKGROUND: Longitudinal motor assessment in infants at different neurodevelopmental risk has not been previously evaluated using structured assessments. AIM: To verify if the Hammersmith Infant Neurological Examination (HINE) is a good tool to predict the neuromotor outcome in infants discharged from a level II-III Neonatal Intensive Care Unit (NICU) METHODS: In this cohort analysis, 1541 infants discharged from our NICU between January of 2002 and the April 2006 were enrolled and assessed using the HINE at 3, 6, 9, 12 months. At two years, these infants were further assessed, and grouped into infants with normal outcome (1150), with mild disability (321) and with cerebral palsy (70), RESULTS: Correlation analysis of Spearman showed a significant (p < 0.0001) and moderate (r(2) = -0.55 to -0.73) negative correlation between HINE scores (3, 6, 9, 12 months) and neurological outcome at two years. Cut-off scores for each assessment' age were provided as predictive value for cerebral palsy. DISCUSSION: This study mainly showed that HINE, as soon as the first months of life, helps in the process of prediction of neurological outcome at two years of age in a heterogeneous population of infants discharged from an NICU.
Authors: Joanne M George; Roslyn N Boyd; Paul B Colditz; Stephen E Rose; Kerstin Pannek; Jurgen Fripp; Barbara E Lingwood; Melissa M Lai; Annice H T Kong; Robert S Ware; Alan Coulthard; Christine M Finn; Sasaka E Bandaranayake Journal: BMC Pediatr Date: 2015-09-16 Impact factor: 2.125
Authors: Roslyn N Boyd; Jenny Ziviani; Leanne Sakzewski; Iona Novak; Nadia Badawi; Kerstin Pannek; Catherine Elliott; Susan Greaves; Andrea Guzzetta; Koa Whittingham; Jane Valentine; Cathy Morgan; Margaret Wallen; Ann-Christin Eliasson; Lisa Findlay; Robert Ware; Simona Fiori; Stephen Rose Journal: BMJ Open Date: 2017-09-18 Impact factor: 2.692
Authors: Essi Heinonen; Barbara Szymanska-von Schultz; Viktor Kaldo; Josefine Nasiell; Ewa Andersson; Mikaela Bergmark; Margareta Blomdahl-Wetterholm; Lisa Forsberg; Erik Forsell; Anna Forsgren; Sandra Frööjd; Amy Goldman; Eva-Mari Nordenadler; Myrto Sklivanioti; Mats Blennow; Katarina Wide; Lars L Gustafsson Journal: BMJ Open Date: 2018-08-05 Impact factor: 2.692