Literature DB >> 33251606

Ion collection efficiency of ionization chambers in ultra-high dose-per-pulse electron beams.

Rafael Kranzer1,2, Daniela Poppinga1, Jan Weidner1, Andreas Schüller3, Thomas Hackel3, Hui Khee Looe2, Björn Poppe2.   

Abstract

PURPOSE: The ion collection efficiency of vented ionization chambers has been investigated in an ultra-high dose-per-pulse (DPP) electron beam. The role of the chamber design and the electric field strength in the sensitive air volume have been evaluated.
METHODS: An advanced Markus chamber and three specially designed parallel plate air-filled ionization chambers (EWC: End Window Chamber) with varying electrode distance of 0.5, 1, and 2 mm have been investigated. Their ion collection efficiencies were determined experimentally using two methods: extrapolation of Jaffé plots and comparison against a DPP-independent reference detector. The latter was achieved by calibrating a current transformer against alanine dosimeters. All measurements were performed in a 24 MeV electron beam with DPP values between 0.01 and 3 Gy. Additionally, the numerical approach introduced by Gotz et al. was implemented taking into account space charge effects at these ultra-high DPPs. The method has been extended to obtain time-resolved and position-dependent electric field distortions within the air cavity.
RESULTS: The ion collection efficiency of the investigated ionization chambers drops significantly in the ultra-high DPP range. The extent of this drop is dependent on the electrode distance, the applied chamber voltage and thus the field strength in the sensitive air volume. For the Advanced Markus chamber, a good agreement between the experimental, numerical and the results of Petersson et al. could be shown. Using the three EWCs with different electrode spacing, an improvement of the ion collection efficiency and a reduction of the polarity effect with decreasing electrode distance could be demonstrated. Furthermore, the results revealed that the determination of the ion collection efficiency from the Jaffé plots and therefore also from two-voltage method typically underestimate the ion collection efficiency in the region of high dose-per-pulse (3 to 130 mGy) and overestimate the ion collection efficiency at ultra-high dose-per-pulse (>1 Gy per pulse).
CONCLUSIONS: In this work, the ion collection efficiency determined with different methods and ionization chambers have been compared and discussed. As expected, an increase of the electric field in the ionization chamber, either by applying a higher bias voltage or a reduction of the electrode distance, improves the ion collection efficiency and also reduces the polarity effect. For the Advanced Markus chamber, the experimental results obtained by comparison against a reference agree well with the numerical solution. Based on these results, it seems possible to keep the recombination loss less than or equal to 5% up to a dose-per-pulse of 3 Gy with an appropriately designed ionization chamber, which corresponds to the level accepted in conventional radiotherapy dosimetry protocols.
© 2020 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine.

Entities:  

Keywords:  FLASH; ion collection efficiency; ionization chamber; ultra-high dose-per-pulse

Mesh:

Year:  2021        PMID: 33251606     DOI: 10.1002/mp.14620

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  6 in total

1.  Ultra-high dose rate radiation production and delivery systems intended for FLASH.

Authors:  Jonathan Farr; Veljko Grilj; Victor Malka; Srinivasan Sudharsan; Marco Schippers
Journal:  Med Phys       Date:  2022-05-05       Impact factor: 4.506

Review 2.  A roadmap to clinical trials for FLASH.

Authors:  Paige A Taylor; Jean M Moran; David A Jaffray; Jeffrey C Buchsbaum
Journal:  Med Phys       Date:  2022-04-25       Impact factor: 4.506

3.  Application of a novel diamond detector for commissioning of FLASH radiotherapy electron beams.

Authors:  Gianluca Verona Rinati; Giuseppe Felici; Federica Galante; Alessia Gasparini; Rafael Kranzer; Giulia Mariani; Matteo Pacitti; Giuseppe Prestopino; Andreas Schüller; Verdi Vanreusel; Dirk Verellen; Claudio Verona; Marco Marinelli
Journal:  Med Phys       Date:  2022-06-16       Impact factor: 4.506

4.  Development of an ultra-thin parallel plate ionization chamber for dosimetry in FLASH radiotherapy.

Authors:  Faustino Gómez; Diego M Gonzalez-Castaño; Nicolás Gómez Fernández; Juan Pardo-Montero; Andreas Schüller; Alessia Gasparini; Verdi Vanreusel; Dirk Verellen; Giuseppe Felici; Rafael Kranzer; Jose Paz-Martín
Journal:  Med Phys       Date:  2022-04-22       Impact factor: 4.506

5.  Ultra-high dose rate dosimetry: Challenges and opportunities for FLASH radiation therapy.

Authors:  Francesco Romano; Claude Bailat; Patrik Gonçalves Jorge; Michael Lloyd Franz Lerch; Arash Darafsheh
Journal:  Med Phys       Date:  2022-05-07       Impact factor: 4.506

6.  Design, realization, and characterization of a novel diamond detector prototype for FLASH radiotherapy dosimetry.

Authors:  Marco Marinelli; Giuseppe Felici; Federica Galante; Alessia Gasparini; Lucia Giuliano; Sophie Heinrich; Matteo Pacitti; Giuseppe Prestopino; Verdi Vanreusel; Dirk Verellen; Claudio Verona; Gianluca Verona Rinati
Journal:  Med Phys       Date:  2022-01-31       Impact factor: 4.506

  6 in total

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