Carol Talla1, Ijeoma Uchenna Itanyi2,3, Kiyomi Tsuyuki4, Nicole Stadnick5,6, Amaka Grace Ogidi2, Babayemi Oluwaseun Olakunde2,7, Dina Patel8, John Okpanachi Oko1, Gregory Aarons5,6, Chima Ariel Onoka2,3, Echezona Edozie Ezeanolue2,8. 1. Caritas Nigeria, Abuja, Federal Capital Territory, Nigeria. 2. Center for Translation and Implementation Research, University of Nigeria Nsukka, Enugu, Nigeria. 3. Department of Community Medicine, University of Nigeria Nsukka, Enugu, Nigeria. 4. Division of Infectious Diseases & Global Public Health, Department of Medicine, University of California, San Diego, CA, USA. 5. Department of Psychiatry, University of California, San Diego, CA, USA. 6. UC San Diego Dissemination and Implementation Science Center, San Diego, CA, USA. 7. National Agency for the Control of AIDS, Abuja, Nigeria. 8. Healthy Sunrise Foundation, Las Vegas, NV, USA.
Abstract
OBJECTIVES: To determine the population prevalence and determinants of hepatitis B (Hep B) status, and status discordance, among pregnant women and their male partners in Nigeria. METHODS: Cross-sectional study assessing the seroprevalence of Hep B virus in a cohort of 16 920 pregnant women and their male partners in northcentral Nigeria. Rapid HBsAg antibody test was used for Hep B diagnosis. Demographic, socio-economic and behavioural information was collected through interviewer-administered questionnaires and evaluated as determinants of Hep B status and couple status discordance using logistic regression. RESULTS: Of 16 920 participants who had a Hep B test result, 6750 couples and 1316 discordant couples were identified. The prevalence of Hep B among all participants was 10.9%, with lower prevalence among pregnant women (10.2%) than their male partners (11.9%), P < 0.001. The prevalence of Hep B sero-discordance among couples was 19.5% (1316/6750). Younger age, prior Hep B testing and a prior positive Hep B test increased the odds of Hep B infection while being a woman decreased the odds of Hep B among all participants, and among couples. Furthermore, polygamy (adjusted odds ratio [AOR]: 1.49, 95% confidence interval [CI]: 1.19-1.87), prior Hep B testing (AOR: 2.38, 95% CI: 1.14-4.97) and a prior positive Hep B test result were significant determinants of status discordance among the participating couples. CONCLUSION: The prevalence of Hep B among pregnant women and their male partners in northcentral Nigeria is high. A large-scale intervention is required to reduce Hep B prevalence in this setting.
OBJECTIVES: To determine the population prevalence and determinants of hepatitis B (Hep B) status, and status discordance, among pregnant women and their male partners in Nigeria. METHODS: Cross-sectional study assessing the seroprevalence of Hep B virus in a cohort of 16 920 pregnant women and their male partners in northcentral Nigeria. Rapid HBsAg antibody test was used for Hep B diagnosis. Demographic, socio-economic and behavioural information was collected through interviewer-administered questionnaires and evaluated as determinants of Hep B status and couple status discordance using logistic regression. RESULTS: Of 16 920 participants who had a Hep B test result, 6750 couples and 1316 discordant couples were identified. The prevalence of Hep B among all participants was 10.9%, with lower prevalence among pregnant women (10.2%) than their male partners (11.9%), P < 0.001. The prevalence of Hep B sero-discordance among couples was 19.5% (1316/6750). Younger age, prior Hep B testing and a prior positive Hep B test increased the odds of Hep B infection while being a woman decreased the odds of Hep B among all participants, and among couples. Furthermore, polygamy (adjusted odds ratio [AOR]: 1.49, 95% confidence interval [CI]: 1.19-1.87), prior Hep B testing (AOR: 2.38, 95% CI: 1.14-4.97) and a prior positive Hep B test result were significant determinants of status discordance among the participating couples. CONCLUSION: The prevalence of Hep B among pregnant women and their male partners in northcentral Nigeria is high. A large-scale intervention is required to reduce Hep B prevalence in this setting.
Authors: R P Beasley; L Y Hwang; C E Stevens; C C Lin; F J Hsieh; K Y Wang; T S Sun; W Szmuness Journal: Hepatology Date: 1983 Mar-Apr Impact factor: 17.425
Authors: Norah A Terrault; Natalie H Bzowej; Kyong-Mi Chang; Jessica P Hwang; Maureen M Jonas; M Hassan Murad Journal: Hepatology Date: 2015-11-13 Impact factor: 17.425
Authors: Echezona E Ezeanolue; Michael C Obiefune; Wei Yang; Chinenye O Ezeanolue; Jennifer Pharr; Alice Osuji; Amaka G Ogidi; Aaron T Hunt; Dina Patel; Gbenga Ogedegbe; John E Ehiri Journal: AIDS Behav Date: 2017-02
Authors: Echezona E Ezeanolue; Michael C Obiefune; Wei Yang; Stephen K Obaro; Chinenye O Ezeanolue; Gbenga G Ogedegbe Journal: Implement Sci Date: 2013-06-08 Impact factor: 7.327
Authors: Babayemi O Olakunde; Daniel A Adeyinka; Olubunmi A Olakunde; Olalekan A Uthman; Florence O Bada; Yvonne A Nartey; Dorcas Obiri-Yeboah; Elijah Paintsil; Echezona E Ezeanolue Journal: PLoS One Date: 2021-10-29 Impact factor: 3.240