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Literature DB >> 33247543

Advances on liver cell-derived exosomes in liver diseases.

Yan Jiao^1,2, Ping Xu^1,2, Honglin Shi^1,2, Dexi Chen^1,2, Hongbo Shi^1,2.

Abstract

Exosomes are extracellular vesicles with diameters ranging from 30 to 150 nm, which contain several donor cell-associated proteins as well as mRNA, miRNA, and lipids and coordinate multiple physiological and pathological functions through horizontal communication between cells. Almost all types of liver cells, such as hepatocytes and Kupffer cells, are exosome-releasing and/or exosome-targeted cells. Exosomes secreted by liver cells play an important role in regulating general physiological functions and also participate in the onset and development of liver diseases, including liver cancer, liver injury, liver fibrosis and viral hepatitis. Liver cell-derived exosomes carry liver cell-specific proteins and miRNAs, which can be used as diagnostic biomarkers and treatment targets of liver disease. This review discusses the functions of exosomes derived from different liver cells and provides novel insights based on the latest developments regarding the roles of exosomes in the diagnosis and treatment of liver diseases.

Entities: CellLine Chemical Disease Gene Species

Keywords: biomarker; exosome; hepatocyte; liver disease

Year: 2020 PMID： 33247543 PMCID： PMC7810930 DOI： 10.1111/jcmm.16123

Source DB: PubMed Journal: J Cell Mol Med ISSN： 1582-1838 Impact factor: 5.310

88 in total

1. Cholangiocyte-derived exosomal long noncoding RNA H19 promotes cholestatic liver injury in mouse and humans.

Authors: Xiaojiaoyang Li; Runping Liu; Zhiming Huang; Emily C Gurley; Xuan Wang; Juan Wang; Hongliang He; Hu Yang; Guanhua Lai; Luyong Zhang; Jasmohan S Bajaj; Melanie White; William M Pandak; Phillip B Hylemon; Huiping Zhou
Journal: Hepatology Date: 2018-05-02 Impact factor: 17.425

2. Extracellular Vesicles as Messengers Between Hepatocytes and Macrophages in Nonalcoholic Steatohepatitis.

Authors: Jörn M Schattenberg; Myung-Shik Lee
Journal: Gastroenterology Date: 2016-02-27 Impact factor: 22.682

3. Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication.

Authors: Silvia Giugliano; Michael Kriss; Lucy Golden-Mason; Evgenia Dobrinskikh; Amy E L Stone; Alejandro Soto-Gutierrez; Angela Mitchell; Salman R Khetani; Daisuke Yamane; Mark Stoddard; Hui Li; George M Shaw; Michael G Edwards; Stanley M Lemon; Michael Gale; Vijay H Shah; Hugo R Rosen
Journal: Gastroenterology Date: 2014-11-04 Impact factor: 22.682

4. Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1.

Authors: Li Chen; Ruju Chen; Sherri Kemper; Alyssa Charrier; David R Brigstock
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2015-07-30 Impact factor: 4.052

5. Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humans in vitro.

Authors: Quan Rao; Bingfeng Zuo; Zhen Lu; Xianjun Gao; Abin You; Chenxuan Wu; Zhi Du; HaiFang Yin
Journal: Hepatology Date: 2016-04-15 Impact factor: 17.425

6. Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes.

Authors: Javier Conde-Vancells; Eva Rodriguez-Suarez; Nieves Embade; David Gil; Rune Matthiesen; Mikel Valle; Felix Elortza; Shelly C Lu; Jose M Mato; Juan M Falcon-Perez
Journal: J Proteome Res Date: 2008-12 Impact factor: 4.466

7. Lipid-Induced Signaling Causes Release of Inflammatory Extracellular Vesicles From Hepatocytes.

Authors: Petra Hirsova; Samar H Ibrahim; Anuradha Krishnan; Vikas K Verma; Steven F Bronk; Nathan W Werneburg; Michael R Charlton; Vijay H Shah; Harmeet Malhi; Gregory J Gores
Journal: Gastroenterology Date: 2016-01-05 Impact factor: 22.682

8. X-inactive-specific transcript of peripheral blood cells is regulated by exosomal Jpx and acts as a biomarker for female patients with hepatocellular carcinoma.

Authors: Xiang Ma; Tingdong Yuan; Chao Yang; Zusen Wang; Yunjin Zang; Liqun Wu; Likun Zhuang
Journal: Ther Adv Med Oncol Date: 2017-09-21 Impact factor: 8.168

9. MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1-mediated autophagy.

Authors: Jianliang Chen; Yue Yu; Shu Li; Yuting Liu; Shu Zhou; Shouji Cao; Jie Yin; Guoqiang Li
Journal: J Cell Mol Med Date: 2017-08-01 Impact factor: 5.310

Review 10. Advances on liver cell-derived exosomes in liver diseases.

Authors: Yan Jiao; Ping Xu; Honglin Shi; Dexi Chen; Hongbo Shi
Journal: J Cell Mol Med Date: 2020-11-27 Impact factor: 5.310

9 in total

Review 1. Role of Exosomes in Chronic Liver Disease Development and Their Potential Clinical Applications.

Authors: Chen Wang; Jinwen Liu; Yongmin Yan; Youwen Tan
Journal: J Immunol Res Date: 2022-05-06 Impact factor: 4.493

Review 2. Roles and mechanisms of exosomal non-coding RNAs in human health and diseases.

Authors: Chen Li; Yu-Qing Ni; Hui Xu; Qun-Yan Xiang; Yan Zhao; Jun-Kun Zhan; Jie-Yu He; Shuang Li; You-Shuo Liu
Journal: Signal Transduct Target Ther Date: 2021-11-10

Review 3. Pathogenic and Potential Therapeutic Roles of Exosomes Derived From Immune Cells in Liver Diseases.

Authors: Leyu Zhou; Mengyi Shen; Xiaoli Fan; Yifeng Liu; Li Yang
Journal: Front Immunol Date: 2022-02-04 Impact factor: 7.561

Review 4. Autophagy and Exosomes: Cross-Regulated Pathways Playing Major Roles in Hepatic Stellate Cells Activation and Liver Fibrosis.

Authors: Eleftheria M Mastoridou; Anna C Goussia; Georgios K Glantzounis; Panagiotis Kanavaros; Antonia V Charchanti
Journal: Front Physiol Date: 2022-02-03 Impact factor: 4.566